SEC Form 4 reporting owner

Opaleye Management Inc.

Opaleye Management Inc. has filed 127 Form 4 transactions reported between November 24, 2025 and September 23, 2026, as 10% owner of Grace Therapeutics, Inc., 10% owner of Alpha Cognition Inc., 10% owner of Sol-Gel Technologies Ltd., 10% owner of Eton Pharmaceuticals, Inc., 10% owner of SANUWAVE Health, Inc. and 10% owner of HARROW, INC..

Name as filed: Opaleye Management Inc.

Open-market buys, 24 mo
$18.3M
103 lines
Open-market sales, 24 mo
$17.2M
24 lines
Companies
6
with Form 4 filings
Latest transaction
Sep 23, 2026
transaction date

Roles and reported holdings

  • GRCEGrace Therapeutics, Inc.
    Aug 14, 2026 – Sep 23, 2026

    10% owner

    Held indirectly (latest line)2,855,318 sh as of Sep 23, 2026 · Form 4

    24 months: $88K bought

  • ACOGAlpha Cognition Inc.
    Feb 20, 2026 – Sep 16, 2026

    10% owner

    Held indirectly (latest line)3,172,141 sh as of Sep 16, 2026 · Form 4

    24 months: $7.2M bought

  • SLGLSol-Gel Technologies Ltd.
    Nov 24, 2025 – Sep 11, 2026

    10% owner

    Held indirectly (latest line)540,000 sh as of Sep 11, 2026 · Form 4

    24 months: $11.0M bought

  • ETONEton Pharmaceuticals, Inc.
    Jul 2, 2026 – Jul 14, 2026

    10% owner

    Held indirectly (latest line)40,000 sh as of Jul 14, 2026 · Form 4

    24 months: $5.8M sold

  • SNWVSANUWAVE Health, Inc.
    Apr 17, 2026 – May 1, 2026

    10% owner

    Held indirectly (latest line)5,000 sh as of May 1, 2026 · Form 4

    24 months: $2.2M sold

  • HROWHARROW, INC.
    Jan 6, 2026 – Mar 4, 2026

    10% owner

    Held indirectly (latest line)59,428 sh as of Mar 4, 2026 · Form 4

    24 months: $9.2M sold

Transaction history

All 127 reported transactions, newest first. Every row links to the Form 4 on SEC EDGAR.

DateCompanyTypeSharesValueFiling
Sep 23, 2026GRCE10% ownerOpen-market purchaseCode P · indirect5,318$11K@ $2.10Form 4
Sep 21, 2026GRCE10% ownerOpen-market purchaseCode P · indirect9,771$21K@ $2.10Form 4
Sep 16, 2026ACOG10% ownerOpen-market purchaseCode P · indirect27,141$228K@ $8.40Form 4
Sep 16, 2026ACOG10% ownerOpen-market purchaseCode P · indirect53,029$455K@ $8.57Form 4
Sep 15, 2026ACOG10% ownerOpen-market purchaseCode P · indirect3,375$29K@ $8.54Form 4
Sep 14, 2026ACOG10% ownerOpen-market purchaseCode P · indirect40,373$351K@ $8.70Form 4
Sep 11, 2026SLGL10% ownerOpen-market purchaseCode P · indirect1,493$98K@ $65.94Form 4
Sep 10, 2026SLGL10% ownerOpen-market purchaseCode P · indirect1,631$109K@ $66.80Form 4
Sep 9, 2026GRCE10% ownerOpen-market purchaseCode P · indirect5,836$12K@ $2.09Form 4
Sep 9, 2026SLGL10% ownerOpen-market purchaseCode P · indirect3,097$213K@ $68.70Form 4
Sep 8, 2026GRCE10% ownerOpen-market purchaseCode P · indirect9,393$20K@ $2.10Form 4
Sep 8, 2026SLGL10% ownerOpen-market purchaseCode P · indirect471$33K@ $69.37Form 4
Sep 8, 2026SLGL10% ownerOpen-market purchaseCode P · indirect3,390$233K@ $68.74Form 4
Sep 4, 2026SLGL10% ownerOpen-market purchaseCode P · indirect2,100$145K@ $68.98Form 4
Sep 4, 2026SLGL10% ownerOpen-market purchaseCode P · indirect918$64K@ $69.52Form 4
Sep 2, 2026SLGL10% ownerOpen-market purchaseCode P · indirect900$62K@ $68.95Form 4
Sep 1, 2026SLGL10% ownerOpen-market purchaseCode P · indirect783$54K@ $69.52Form 4
Aug 31, 2026SLGL10% ownerOpen-market purchaseCode P · indirect217$15K@ $69.10Form 4
Aug 31, 2026SLGL10% ownerOpen-market purchaseCode P · indirect5,000$341K@ $68.23Form 4
Aug 28, 2026SLGL10% ownerOpen-market purchaseCode P · indirect5,000$344K@ $68.81Form 4
Aug 28, 2026SLGL10% ownerOpen-market purchaseCode P · indirect20,113$1.4M@ $68.42Form 4
Aug 28, 2026SLGL10% ownerOpen-market purchaseCode P · indirect10,000$714K@ $71.40Form 4
Aug 14, 2026GRCE10% ownerOpen-market purchaseCode P · indirect11,608$24K@ $2.09Form 4
Aug 12, 2026SLGL10% ownerOpen-market purchaseCode P · indirect951$68K@ $71.50Form 4
Aug 3, 2026ACOG10% ownerOpen-market purchaseCode P · indirect50,000$400K@ $8.00Form 4
Jul 31, 2026ACOG10% ownerOpen-market purchaseCode P · indirect2,900$23K@ $7.92Form 4
Jul 24, 2026ACOG10% ownerOpen-market purchaseCode P · indirect130$1K@ $7.90Form 4
Jul 23, 2026ACOG10% ownerOpen-market purchaseCode P · indirect49,849$389K@ $7.80Form 4
Jul 22, 2026ACOG10% ownerOpen-market purchaseCode P · indirect10,000$78K@ $7.83Form 4
Jul 22, 2026ACOG10% ownerOpen-market purchaseCode P · indirect140,237$1.1M@ $7.83Form 4
Jul 14, 2026ETON10% ownerOpen-market saleCode S · indirect13,315$500K@ $37.54Form 4
Jul 14, 2026ETON10% ownerOpen-market saleCode S · indirect15,000$563K@ $37.54Form 4
Jul 14, 2026SLGL10% ownerOpen-market purchaseCode P · indirect920$68K@ $73.43Form 4
Jul 13, 2026SLGL10% ownerOpen-market purchaseCode P · indirect775$57K@ $73.89Form 4
Jul 10, 2026SLGL10% ownerOpen-market purchaseCode P · indirect229$17K@ $73.95Form 4
Jul 8, 2026SLGL10% ownerOpen-market purchaseCode P · indirect300$22K@ $73.69Form 4
Jul 7, 2026ETON10% ownerOpen-market saleCode S · indirect6,685$257K@ $38.37Form 4
Jul 7, 2026ETON10% ownerOpen-market saleCode S · indirect20,000$767K@ $38.37Form 4
Jul 6, 2026ETON10% ownerOpen-market saleCode S · indirect10,000$380K@ $38.00Form 4
Jul 2, 2026ETON10% ownerOpen-market saleCode S · indirect25,000$935K@ $37.39Form 4
Jul 2, 2026ETON10% ownerOpen-market saleCode S · indirect65,000$2.4M@ $37.39Form 4
Jul 2, 2026SLGL10% ownerOpen-market purchaseCode P · indirect1,400$101K@ $71.97Form 4
Jul 1, 2026SLGL10% ownerOpen-market purchaseCode P · indirect312$22K@ $71.99Form 4
Jun 26, 2026ACOG10% ownerOpen-market purchaseCode P · indirect152,336$975K@ $6.40Form 4
Jun 25, 2026ACOG10% ownerOpen-market purchaseCode P · indirect197$1K@ $6.50Form 4
Jun 15, 2026ACOG10% ownerOpen-market purchaseCode P · indirect4,550$27K@ $5.99Form 4
Jun 12, 2026ACOG10% ownerOpen-market purchaseCode P · indirect273$2K@ $5.93Form 4
Jun 11, 2026ACOG10% ownerOpen-market purchaseCode P · indirect2,862$17K@ $5.91Form 4
Jun 10, 2026ACOG10% ownerOpen-market purchaseCode P · indirect5,872$35K@ $5.99Form 4
Jun 9, 2026ACOG10% ownerOpen-market purchaseCode P · indirect24,856$149K@ $5.98Form 4
Jun 5, 2026ACOG10% ownerOpen-market purchaseCode P · indirect10,054$59K@ $5.83Form 4
May 29, 2026ACOG10% ownerOpen-market purchaseCode P · indirect70,577$416K@ $5.90Form 4
May 28, 2026ACOG10% ownerOpen-market purchaseCode P · indirect2,000$12K@ $5.83Form 4
May 27, 2026ACOG10% ownerOpen-market purchaseCode P · indirect1,161$7K@ $5.73Form 4
May 21, 2026ACOG10% ownerOpen-market purchaseCode P · indirect15,945$91K@ $5.70Form 4
May 20, 2026SLGL10% ownerOpen-market purchaseCode P · indirect1,563$101K@ $64.43Form 4
May 20, 2026ACOG10% ownerOpen-market purchaseCode P · indirect8,431$50K@ $5.89Form 4
May 18, 2026ACOG10% ownerOpen-market purchaseCode P · indirect17,395$99K@ $5.69Form 4
May 15, 2026ACOG10% ownerOpen-market purchaseCode P · indirect16,648$97K@ $5.83Form 4
May 13, 2026SLGL10% ownerOpen-market purchaseCode P · indirect1,937$130K@ $66.87Form 4
May 12, 2026SLGL10% ownerOpen-market purchaseCode P · indirect1,500$102K@ $67.98Form 4
May 1, 2026SNWV10% ownerOpen-market saleCode S · indirect500$8K@ $16.11Form 4
May 1, 2026SNWV10% ownerOpen-market saleCode S · indirect10,081$162K@ $16.11Form 4
Apr 30, 2026SNWV10% ownerOpen-market saleCode S · indirect1,000$16K@ $16.15Form 4
Apr 30, 2026SNWV10% ownerOpen-market saleCode S · indirect24,000$388K@ $16.15Form 4
Apr 29, 2026SNWV10% ownerOpen-market saleCode S · indirect1,000$17K@ $17.25Form 4
Apr 29, 2026SNWV10% ownerOpen-market saleCode S · indirect23,360$403K@ $17.25Form 4
Apr 28, 2026SNWV10% ownerOpen-market saleCode S · indirect2,500$46K@ $18.47Form 4
Apr 28, 2026SNWV10% ownerOpen-market saleCode S · indirect43,788$809K@ $18.47Form 4
Apr 21, 2026SNWV10% ownerOpen-market saleCode S · indirect202$4K@ $20.50Form 4
Apr 17, 2026SNWV10% ownerOpen-market saleCode S · indirect5,000$102K@ $20.46Form 4
Apr 17, 2026SNWV10% ownerOpen-market saleCode S · indirect11,267$231K@ $20.46Form 4
Mar 30, 2026ACOG10% ownerOpen-market purchaseCode P · indirect1,850$9K@ $4.99Form 4
Mar 27, 2026ACOG10% ownerOpen-market purchaseCode P · indirect10,000$51K@ $5.08Form 4
Mar 26, 2026ACOG10% ownerOpen-market purchaseCode P · indirect7,319$39K@ $5.28Form 4
Mar 25, 2026ACOG10% ownerOpen-market purchaseCode P · indirect8,581$47K@ $5.43Form 4
Mar 24, 2026ACOG10% ownerOpen-market purchaseCode P · indirect4,182$23K@ $5.59Form 4
Mar 24, 2026SLGL10% ownerOpen-market purchaseCode P · indirect5,000$360K@ $72.00Form 4
Mar 24, 2026SLGL10% ownerOpen-market purchaseCode P · indirect34,665$2.5M@ $72.00Form 4
Mar 19, 2026ACOG10% ownerOpen-market purchaseCode P · indirect2,094$12K@ $5.71Form 4
Mar 18, 2026ACOG10% ownerOpen-market purchaseCode P · indirect2,481$14K@ $5.75Form 4
Mar 16, 2026ACOG10% ownerOpen-market purchaseCode P · indirect1,331$8K@ $5.78Form 4
Mar 13, 2026ACOG10% ownerOpen-market purchaseCode P · indirect7,358$42K@ $5.75Form 4
Mar 12, 2026ACOG10% ownerOpen-market purchaseCode P · indirect5,708$33K@ $5.85Form 4
Mar 9, 2026ACOG10% ownerOpen-market purchaseCode P · indirect2,179$13K@ $5.85Form 4
Mar 6, 2026ACOG10% ownerOpen-market purchaseCode P · indirect1,900$11K@ $5.80Form 4
Mar 5, 2026ACOG10% ownerOpen-market purchaseCode P · indirect5,000$29K@ $5.80Form 4
Mar 5, 2026ACOG10% ownerOpen-market purchaseCode P · indirect42,023$244K@ $5.80Form 4
Mar 4, 2026HROW10% ownerOpen-market saleCode S · indirect4,263$169K@ $39.67Form 4
Mar 4, 2026HROW10% ownerOpen-market saleCode S · indirect134,000$5.3M@ $39.67Form 4
Mar 4, 2026ACOG10% ownerOpen-market purchaseCode P · indirect19,795$115K@ $5.81Form 4
Mar 3, 2026HROW10% ownerOpen-market saleCode S · indirect1,309$51K@ $39.15Form 4
Mar 3, 2026HROW10% ownerOpen-market saleCode S · indirect59,000$2.3M@ $39.15Form 4
Mar 3, 2026ACOG10% ownerOpen-market purchaseCode P · indirect5,000$29K@ $5.75Form 4
Mar 3, 2026ACOG10% ownerOpen-market purchaseCode P · indirect46,411$267K@ $5.75Form 4
Mar 2, 2026ACOG10% ownerOpen-market purchaseCode P · indirect20,000$116K@ $5.80Form 4
Feb 27, 2026HROW10% ownerOpen-market saleCode S · indirect5,000$271K@ $54.18Form 4
Feb 27, 2026ACOG10% ownerOpen-market purchaseCode P · indirect3,638$22K@ $5.99Form 4
Feb 26, 2026ACOG10% ownerOpen-market purchaseCode P · indirect590$4K@ $5.99Form 4
Feb 24, 2026ACOG10% ownerOpen-market purchaseCode P · indirect5,000$29K@ $5.80Form 4
Feb 24, 2026ACOG10% ownerOpen-market purchaseCode P · indirect53,591$311K@ $5.80Form 4
Feb 23, 2026ACOG10% ownerOpen-market purchaseCode P · indirect4,181$25K@ $5.89Form 4
Feb 23, 2026ACOG10% ownerOpen-market purchaseCode P · indirect95,819$565K@ $5.89Form 4
Feb 20, 2026ACOG10% ownerOpen-market purchaseCode P · indirect2,819$16K@ $5.84Form 4
Feb 20, 2026ACOG10% ownerOpen-market purchaseCode P · indirect10,000$58K@ $5.84Form 4
Feb 13, 2026SLGL10% ownerOpen-market purchaseCode P · indirect291$18K@ $63.00Form 4
Feb 2, 2026SLGL10% ownerOpen-market purchaseCode P · indirect100$6K@ $58.00Form 4
Jan 27, 2026SLGL10% ownerOpen-market purchaseCode P · indirect100$6K@ $57.05Form 4
Jan 23, 2026SLGL10% ownerOpen-market purchaseCode P · indirect1,151$64K@ $55.98Form 4
Jan 22, 2026SLGL10% ownerOpen-market purchaseCode P · indirect2,173$123K@ $56.57Form 4
Jan 6, 2026HROW10% ownerOpen-market saleCode S · indirect20,000$1.1M@ $53.35Form 4
Jan 5, 2026SLGL10% ownerOpen-market purchaseCode P · indirect198$9K@ $42.98Form 4
Jan 2, 2026SLGL10% ownerOpen-market purchaseCode P · indirect2,394$100K@ $41.92Form 4
Dec 31, 2025SLGL10% ownerOpen-market purchaseCode P · indirect22,497$945K@ $41.99Form 4
Dec 30, 2025SLGL10% ownerOpen-market purchaseCode P · indirect35,169$1.5M@ $41.99Form 4
Dec 29, 2025SLGL10% ownerOpen-market purchaseCode P · indirect8,638$362K@ $41.85Form 4
Dec 26, 2025SLGL10% ownerOpen-market purchaseCode P · indirect1,626$68K@ $41.68Form 4
Dec 23, 2025SLGL10% ownerOpen-market purchaseCode P · indirect260$11K@ $41.66Form 4
Dec 22, 2025SLGL10% ownerOpen-market purchaseCode P · indirect1,019$42K@ $41.15Form 4
Dec 17, 2025SLGL10% ownerOpen-market purchaseCode P · indirect2,735$110K@ $40.37Form 4
Dec 12, 2025SLGL10% ownerOpen-market purchaseCode P · indirect87$3K@ $40.00Form 4
Dec 8, 2025SLGL10% ownerOpen-market purchaseCode P · indirect300$12K@ $39.77Form 4
Dec 5, 2025SLGL10% ownerOpen-market purchaseCode P · indirect444$18K@ $39.50Form 4
Dec 3, 2025SLGL10% ownerOpen-market purchaseCode P · indirect2,524$95K@ $37.81Form 4
Dec 1, 2025SLGL10% ownerOpen-market purchaseCode P · indirect4,340$162K@ $37.37Form 4
Nov 26, 2025SLGL10% ownerOpen-market purchaseCode P · indirect943$38K@ $40.00Form 4
Nov 24, 2025SLGL10% ownerOpen-market purchaseCode P · indirect6$213@ $35.50Form 4

How this page is built

Every row comes from a Form 4 filed with the SEC, which officers, directors and holders of more than 10% of a company’s stock must file within two business days of a trade. Transactions are grouped by the reporting owner’s name as filed (spacing, capitals and punctuation ignored); two different people filing under an identical name would appear together, and one person filing under two spellings appears on two pages.

Open-market totals count code P purchases and code S sales over the last 24 months. The same trade reported on more than one filing is counted once; when another owner (for example a fund and its general partner) reports the identical trade, they are listed beside it. Holdings are the shares owned after the latest purchase, sale, gift or tax-withholding line, shown separately for direct and indirect ownership; an indirect figure is one holding line, not a total across every trust or entity.

This page describes what was filed with the SEC; it is not investment advice or a recommendation to buy or sell any security.