| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 399 | $366.56 | $146K@ $366.56 | 1,302,145 | Form 4 |
| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 826 | $365.41 | $302K@ $365.41 | 1,302,544 | Form 4 |
| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 1,329 | $364.48 | $484K@ $364.48 | 1,303,370 | Form 4 |
| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 565 | $363.34 | $205K@ $363.34 | 1,304,699 | Form 4 |
| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 1,992 | $362.65 | $722K@ $362.65 | 1,305,264 | Form 4 |
| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 1,242 | $361.61 | $449K@ $361.61 | 1,307,256 | Form 4 |
| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 2,320 | $360.47 | $836K@ $360.47 | 1,308,498 | Form 4 |
| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 3,392 | $359.39 | $1.2M@ $359.39 | 1,310,818 | Form 4 |
| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 3,180 | $358.42 | $1.1M@ $358.42 | 1,314,210 | Form 4 |
| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 3,962 | $357.57 | $1.4M@ $357.57 | 1,317,390 | Form 4 |
| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 3,267 | $356.37 | $1.2M@ $356.37 | 1,321,352 | Form 4 |
| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 2,006 | $355.57 | $713K@ $355.57 | 1,324,619 | Form 4 |
| Sep 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · directAlso reported by Krishnan Krish S | 520 | $354.54 | $184K@ $354.54 | 1,326,625 | Form 4 |
| Jun 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 240 | $311.65 | $75K@ $311.65 | 1,378,155 | Form 4 |
| Jun 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 2,039 | $310.94 | $634K@ $310.94 | 1,378,395 | Form 4 |
| Jun 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 2,801 | $309.95 | $868K@ $309.95 | 1,380,434 | Form 4 |
| Jun 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 3,803 | $308.89 | $1.2M@ $308.89 | 1,383,235 | Form 4 |
| Jun 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 12,729 | $307.81 | $3.9M@ $307.81 | 1,387,038 | Form 4 |
| Jun 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 1,348 | $307.09 | $414K@ $307.09 | 1,399,767 | Form 4 |
| Jun 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 480 | $305.87 | $147K@ $305.87 | 1,401,115 | Form 4 |
| Jun 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 400 | $304.89 | $122K@ $304.89 | 1,401,595 | Form 4 |
| Jun 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 247 | $303.17 | $75K@ $303.17 | 1,401,995 | Form 4 |
| Jun 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 593 | $302.25 | $179K@ $302.25 | 1,402,242 | Form 4 |
| Jun 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · directAlso reported by Krishnan Krish S | 320 | $300.75 | $96K@ $300.75 | 1,402,835 | Form 4 |
| Mar 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 1,700 | $266.42 | $453K@ $266.42 | 1,403,155 | Form 4 |
| Mar 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 6,000 | $265.16 | $1.6M@ $265.16 | 1,404,855 | Form 4 |
| Mar 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 4,852 | $264.64 | $1.3M@ $264.64 | 1,410,855 | Form 4 |
| Mar 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 2,248 | $263.58 | $593K@ $263.58 | 1,415,707 | Form 4 |
| Mar 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 1,938 | $262.35 | $508K@ $262.35 | 1,417,955 | Form 4 |
| Mar 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 2,931 | $261.41 | $766K@ $261.41 | 1,419,893 | Form 4 |
| Mar 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 3,667 | $260.37 | $955K@ $260.37 | 1,422,824 | Form 4 |
| Mar 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 668 | $259.61 | $173K@ $259.61 | 1,426,491 | Form 4 |
| Mar 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 589 | $258.54 | $152K@ $258.54 | 1,427,159 | Form 4 |
| Mar 4, 2026 | KRYSPresident, R&D | Open-market saleCode S · direct | 407 | $257.32 | $105K@ $257.32 | 1,427,748 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Grant or awardCode A · direct | 43,536 | — | — | 43,536 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Grant or awardCode A · direct | 7,256 | — | — | 7,256 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Grant or awardCode A · direct | 18,100 | — | — | 18,100 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Shares withheld for tax or exercise priceCode F · indirect | 2,605 | $275.64 | $718K@ $275.64 | 1,500,253 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Option exerciseCode M · indirect | 5,725 | — | — | 1,502,858 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Shares withheld for tax or exercise priceCode F · indirect | 11,942 | $275.64 | $3.3M@ $275.64 | 1,497,133 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Option exerciseCode M · indirect | 26,250 | — | — | 1,509,075 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Shares withheld for tax or exercise priceCode F · indirect | 3,981 | $275.64 | $1.1M@ $275.64 | 1,482,825 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Option exerciseCode M · indirect | 8,750 | — | — | 1,486,806 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Shares withheld for tax or exercise priceCode F · direct | 1,820 | $275.64 | $502K@ $275.64 | 1,428,155 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Option exerciseCode M · direct | 4,000 | — | — | 1,429,975 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Shares withheld for tax or exercise priceCode F · direct | 10,236 | $275.64 | $2.8M@ $275.64 | 1,425,975 | Form 4 |
| Feb 27, 2026 | KRYSPresident, R&D | Option exerciseCode M · direct | 22,500 | — | — | 1,436,211 | Form 4 |
| Dec 5, 2025 | KRYSPresident, R&D | GiftCode G · indirect | 5,000 | — | — | 1,478,056 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · indirectAlso reported by Krishnan Krish S | 10,505 | $221.78 | $2.3M@ $221.78 | 1,483,756 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · indirectAlso reported by Krishnan Krish S | 2,625 | $220.34 | $578K@ $220.34 | 1,494,261 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · indirect | 5,693 | $219.53 | $1.2M@ $219.53 | 1,496,886 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · indirectAlso reported by Krishnan Krish S | 2,577 | $218.72 | $564K@ $218.72 | 1,502,579 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · indirectAlso reported by Krishnan Krish S | 1,600 | $217.04 | $347K@ $217.04 | 1,505,156 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · indirectAlso reported by Krishnan Krish S | 344 | $215.48 | $74K@ $215.48 | 1,506,756 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · indirectAlso reported by Krishnan Krish S | 956 | $214.28 | $205K@ $214.28 | 1,507,100 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · directAlso reported by Krishnan Krish S | 200 | $222.38 | $44K@ $222.38 | 1,413,711 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · directAlso reported by Krishnan Krish S | 10,461 | $221.82 | $2.3M@ $221.82 | 1,413,911 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · directAlso reported by Krishnan Krish S | 2,627 | $220.52 | $579K@ $220.52 | 1,424,372 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · directAlso reported by Krishnan Krish S | 5,419 | $219.68 | $1.2M@ $219.68 | 1,426,999 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · directAlso reported by Krishnan Krish S | 3,593 | $218.83 | $786K@ $218.83 | 1,432,418 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · directAlso reported by Krishnan Krish S | 1,400 | $216.97 | $304K@ $216.97 | 1,436,011 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · directAlso reported by Krishnan Krish S | 600 | $215.49 | $129K@ $215.49 | 1,437,411 | Form 4 |
| Dec 4, 2025 | KRYSPresident, R&D | Open-market saleCode S · direct | 700 | $214.25 | $150K@ $214.25 | 1,438,011 | Form 4 |