| Sep 1, 2026 | ALKSEVP R&D, Chief Medical Officer | Open-market saleCode S · direct | 9,000 | $46.99 | $423K@ $46.99 | 65,389 | Form 4 |
| Sep 1, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 5,000 | $24.59 | $123K@ $24.59 | 74,389 | Form 4 |
| Aug 3, 2026 | ALKSEVP R&D, Chief Medical Officer | Open-market saleCode S · direct | 9,000 | $48.58 | $437K@ $48.58 | 69,389 | Form 4 |
| Aug 3, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 4,896 | $24.59 | $120K@ $24.59 | 78,389 | Form 4 |
| Aug 3, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 104 | $19.34 | $2K@ $19.34 | 73,493 | Form 4 |
| Jul 1, 2026 | ALKSEVP R&D, Chief Medical Officer | Open-market saleCode S · direct | 700 | $52.13 | $36K@ $52.13 | 73,389 | Form 4 |
| Jul 1, 2026 | ALKSEVP R&D, Chief Medical Officer | Open-market saleCode S · direct | 8,300 | $51.46 | $427K@ $51.46 | 74,089 | Form 4 |
| Jul 1, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 5,000 | $19.34 | $97K@ $19.34 | 82,389 | Form 4 |
| Jun 1, 2026 | ALKSEVP R&D, Chief Medical Officer | Open-market saleCode S · direct | 9,000 | $41.67 | $375K@ $41.67 | 77,389 | Form 4 |
| Jun 1, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 5,000 | $19.34 | $97K@ $19.34 | 86,389 | Form 4 |
| May 1, 2026 | ALKSEVP R&D, Chief Medical Officer | Open-market saleCode S · direct | 9,000 | $33.40 | $301K@ $33.40 | 81,389 | Form 4 |
| May 1, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 5,000 | $19.34 | $97K@ $19.34 | 90,389 | Form 4 |
| Apr 1, 2026 | ALKSEVP R&D, Chief Medical Officer | Open-market saleCode S · direct | 9,000 | $35.51 | $320K@ $35.51 | 85,389 | Form 4 |
| Apr 1, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 5,000 | $19.34 | $97K@ $19.34 | 94,389 | Form 4 |
| Mar 2, 2026 | ALKSEVP R&D, Chief Medical Officer | Grant or awardCode A · direct | 38,568 | — | — | 38,568 | Form 4 |
| Mar 2, 2026 | ALKSEVP R&D, Chief Medical Officer | Grant or awardCode A · direct | 83,037 | — | — | 83,037 | Form 4 |
| Mar 2, 2026 | ALKSEVP R&D, Chief Medical Officer | Open-market saleCode S · direct | 9,000 | $29.72 | $267K@ $29.72 | 89,389 | Form 4 |
| Mar 2, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 5,000 | $19.34 | $97K@ $19.34 | 98,389 | Form 4 |
| Feb 26, 2026 | ALKSEVP R&D, Chief Medical Officer | Shares withheld for tax or exercise priceCode F · direct | 3,049 | $30.73 | $94K@ $30.73 | 93,389 | Form 4 |
| Feb 26, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 6,866 | — | — | 96,438 | Form 4 |
| Feb 23, 2026 | ALKSEVP R&D, Chief Medical Officer | Shares withheld for tax or exercise priceCode F · direct | 3,414 | $32.19 | $110K@ $32.19 | 89,572 | Form 4 |
| Feb 23, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 7,689 | — | — | 92,986 | Form 4 |
| Feb 19, 2026 | ALKSEVP R&D, Chief Medical Officer | Shares withheld for tax or exercise priceCode F · direct | 3,407 | $32.00 | $109K@ $32.00 | 85,297 | Form 4 |
| Feb 19, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 7,673 | — | — | 88,704 | Form 4 |
| Feb 18, 2026 | ALKSEVP R&D, Chief Medical Officer | Shares withheld for tax or exercise priceCode F · direct | 3,504 | $32.02 | $112K@ $32.02 | 81,031 | Form 4 |
| Feb 18, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 8,897 | — | — | 84,535 | Form 4 |
| Feb 5, 2026 | ALKSEVP R&D, Chief Medical Officer | Shares withheld for tax or exercise priceCode F · direct | 7,454 | $33.55 | $250K@ $33.55 | 75,638 | Form 4 |
| Feb 5, 2026 | ALKSEVP R&D, Chief Medical Officer | Grant or awardCode A · direct | 25,352 | — | — | 83,092 | Form 4 |
| Feb 2, 2026 | ALKSEVP R&D, Chief Medical Officer | Open-market saleCode S · direct | 4,000 | $33.54 | $134K@ $33.54 | 57,740 | Form 4 |
| Feb 2, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 5,000 | $19.34 | $97K@ $19.34 | 66,740 | Form 4 |
| Jan 8, 2026 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 5,000 | $19.34 | $97K@ $19.34 | 66,740 | Form 4 |
| Jan 2, 2026 | ALKSEVP R&D, Chief Medical Officer | Open-market saleCode S · direct | 4,000 | $28.00 | $112K@ $28.00 | 61,740 | Form 4 |
| Dec 3, 2025 | ALKSEVP R&D, Chief Medical Officer | Option exerciseCode M · direct | 3,748 | $19.34 | $72K@ $19.34 | 69,488 | Form 4 |
| Dec 1, 2025 | ALKSEVP R&D, Chief Medical Officer | Open-market saleCode S · direct | 4,000 | $29.30 | $117K@ $29.30 | 65,740 | Form 4 |