| Sep 19, 2026 | ALNYChief Executive Officer | Grant or awardCode A · direct | 107 | — | — | 95,802 | Form 4 |
| Mar 4, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 265 | $325.67 | $86K@ $325.67 | 95,695 | Form 4 |
| Mar 4, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 345 | $324.88 | $112K@ $324.88 | 95,960 | Form 4 |
| Mar 4, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 973 | $323.84 | $315K@ $323.84 | 96,305 | Form 4 |
| Mar 4, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 444 | $323.01 | $143K@ $323.01 | 97,278 | Form 4 |
| Mar 4, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 368 | $321.82 | $118K@ $321.82 | 97,722 | Form 4 |
| Mar 4, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 274 | $320.81 | $88K@ $320.81 | 98,090 | Form 4 |
| Mar 4, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 129 | $320.01 | $41K@ $320.01 | 98,364 | Form 4 |
| Mar 4, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 135 | $319.03 | $43K@ $319.03 | 98,493 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Grant or awardCode A · direct | 110,746 | — | — | 110,746 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Grant or awardCode A · direct | 30,425 | — | — | 30,425 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 160 | $332.64 | $53K@ $332.64 | 98,628 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 399 | $331.93 | $132K@ $331.93 | 98,788 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 346 | $330.85 | $114K@ $330.85 | 99,187 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 722 | $329.71 | $238K@ $329.71 | 99,533 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 424 | $328.71 | $139K@ $328.71 | 100,255 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 1,399 | $327.67 | $458K@ $327.67 | 100,679 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 1,669 | $326.81 | $545K@ $326.81 | 102,078 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 1,098 | $325.63 | $358K@ $325.63 | 103,747 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 382 | $324.65 | $124K@ $324.65 | 104,845 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 200 | $323.62 | $65K@ $323.62 | 105,227 | Form 4 |
| Mar 2, 2026 | ALNYChief Executive Officer | Grant or awardCode A · direct | 13,844 | — | — | 105,427 | Form 4 |
| Feb 27, 2026 | ALNYChief Executive Officer | Option exerciseCode M · direct | 5,921 | — | — | 91,583 | Form 4 |
| Feb 13, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 6,958 | $310.08 | $2.2M@ $310.08 | 85,662 | Form 4 |
| Feb 12, 2026 | ALNYChief Executive Officer | Grant or awardCode A · direct | 14,209 | — | — | 92,620 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 94 | $377.82 | $36K@ $377.82 | 78,411 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 88 | $374.44 | $33K@ $374.44 | 78,623 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 21 | $372.46 | $8K@ $372.46 | 78,711 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 118 | $370.87 | $44K@ $370.87 | 78,732 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 253 | $369.48 | $93K@ $369.48 | 78,850 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 584 | $368.62 | $215K@ $368.62 | 79,103 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 261 | $367.40 | $96K@ $367.40 | 79,687 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 316 | $366.41 | $116K@ $366.41 | 79,948 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 1,395 | $365.56 | $510K@ $365.56 | 80,264 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 1,259 | $364.83 | $459K@ $364.83 | 81,659 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 301 | $363.55 | $109K@ $363.55 | 82,918 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 464 | $362.38 | $168K@ $362.38 | 83,219 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 624 | $361.45 | $226K@ $361.45 | 83,683 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 980 | $360.22 | $353K@ $360.22 | 84,307 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 537 | $359.14 | $193K@ $359.14 | 85,287 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 778 | $358.18 | $279K@ $358.18 | 85,824 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 607 | $357.17 | $217K@ $357.17 | 86,602 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 263 | $356.09 | $94K@ $356.09 | 87,209 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 269 | $355.16 | $96K@ $355.16 | 87,472 | Form 4 |
| Jan 12, 2026 | ALNYChief Executive Officer | Open-market saleCode S · direct | 247 | $353.95 | $87K@ $353.95 | 87,741 | Form 4 |
| Jan 11, 2026 | ALNYChief Executive Officer | Grant or awardCode A · direct | 19,003 | — | — | 87,988 | Form 4 |
| Nov 26, 2025 | ALNYChief Executive Officer | Shares withheld for tax or exercise priceCode F · direct | 1,121 | $445.12 | $499K@ $445.12 | 68,985 | Form 4 |
| Nov 26, 2025 | ALNYChief Executive Officer | Option exerciseCode M · direct | 659 | $151.59 | $100K@ $151.59 | 70,106 | Form 4 |
| Nov 26, 2025 | ALNYChief Executive Officer | Option exerciseCode M · direct | 847 | $118.05 | $100K@ $118.05 | 69,447 | Form 4 |
| Nov 26, 2025 | ALNYChief Executive Officer | Option exerciseCode M · direct | 2,352 | $85.00 | $200K@ $85.00 | 68,600 | Form 4 |
| Nov 26, 2025 | ALNYChief Executive Officer | Option exerciseCode M · direct | 839 | $119.13 | $100K@ $119.13 | 66,248 | Form 4 |