| Sep 16, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 1,654 | $153.24 | $253K@ $153.24 | 0 | Form 4 |
| Sep 16, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 989 | $152.36 | $151K@ $152.36 | 1,654 | Form 4 |
| Sep 16, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 1,659 | $151.16 | $251K@ $151.16 | 2,643 | Form 4 |
| Sep 16, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,148 | $9.08 | $20K@ $9.08 | 4,302 | Form 4 |
| Sep 16, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,154 | $7.14 | $15K@ $7.14 | 2,154 | Form 4 |
| Aug 19, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 302 | $156.77 | $47K@ $156.77 | 0 | Form 4 |
| Aug 19, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 102 | $155.59 | $16K@ $155.59 | 302 | Form 4 |
| Aug 19, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 400 | $153.00 | $61K@ $153.00 | 404 | Form 4 |
| Aug 19, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 1,998 | $151.80 | $303K@ $151.80 | 804 | Form 4 |
| Aug 19, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 1,500 | $151.39 | $227K@ $151.39 | 2,802 | Form 4 |
| Aug 19, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,148 | $9.08 | $20K@ $9.08 | 4,302 | Form 4 |
| Aug 19, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,154 | $7.14 | $15K@ $7.14 | 2,154 | Form 4 |
| Jul 15, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 1,911 | $150.25 | $287K@ $150.25 | 0 | Form 4 |
| Jul 15, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 1,029 | $149.27 | $154K@ $149.27 | 1,911 | Form 4 |
| Jul 15, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 840 | $148.40 | $125K@ $148.40 | 2,940 | Form 4 |
| Jul 15, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 522 | $147.14 | $77K@ $147.14 | 3,780 | Form 4 |
| Jul 15, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,148 | $9.08 | $20K@ $9.08 | 4,302 | Form 4 |
| Jul 15, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,154 | $7.14 | $15K@ $7.14 | 2,154 | Form 4 |
| Jun 17, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 25 | $112.23 | $3K@ $112.23 | 0 | Form 4 |
| Jun 17, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 1,887 | $111.31 | $210K@ $111.31 | 25 | Form 4 |
| Jun 17, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 2,390 | $110.26 | $264K@ $110.26 | 1,912 | Form 4 |
| Jun 17, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,148 | $9.08 | $20K@ $9.08 | 4,302 | Form 4 |
| Jun 17, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,154 | $7.14 | $15K@ $7.14 | 2,154 | Form 4 |
| May 20, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 48 | $111.89 | $5K@ $111.89 | 0 | Form 4 |
| May 20, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 891 | $111.30 | $99K@ $111.30 | 48 | Form 4 |
| May 20, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 3,363 | $110.35 | $371K@ $110.35 | 939 | Form 4 |
| May 20, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,148 | $9.08 | $20K@ $9.08 | 4,302 | Form 4 |
| May 20, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,154 | $7.14 | $15K@ $7.14 | 2,154 | Form 4 |
| Apr 15, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 100 | $130.33 | $13K@ $130.33 | 0 | Form 4 |
| Apr 15, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 639 | $129.17 | $83K@ $129.17 | 100 | Form 4 |
| Apr 15, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 561 | $128.23 | $72K@ $128.23 | 739 | Form 4 |
| Apr 15, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 1,500 | $127.13 | $191K@ $127.13 | 1,300 | Form 4 |
| Apr 15, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 1,502 | $125.96 | $189K@ $125.96 | 2,800 | Form 4 |
| Apr 15, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,148 | $9.08 | $20K@ $9.08 | 4,302 | Form 4 |
| Apr 15, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,154 | $7.14 | $15K@ $7.14 | 2,154 | Form 4 |
| Mar 18, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 304 | $119.08 | $36K@ $119.08 | 0 | Form 4 |
| Mar 18, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 1,730 | $118.37 | $205K@ $118.37 | 304 | Form 4 |
| Mar 18, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 2,268 | $117.56 | $267K@ $117.56 | 2,034 | Form 4 |
| Mar 18, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,148 | $9.08 | $20K@ $9.08 | 4,302 | Form 4 |
| Mar 18, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,154 | $7.14 | $15K@ $7.14 | 2,154 | Form 4 |
| Feb 18, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 1,276 | $79.97 | $102K@ $79.97 | 0 | Form 4 |
| Feb 18, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 3,026 | $79.16 | $240K@ $79.16 | 1,276 | Form 4 |
| Feb 18, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,148 | $9.08 | $20K@ $9.08 | 4,302 | Form 4 |
| Feb 18, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,154 | $7.14 | $15K@ $7.14 | 2,154 | Form 4 |
| Feb 5, 2026 | PVLAChief Operating Officer | Grant or awardCode A · direct | 48,956 | — | — | 48,956 | Form 4 |
| Jan 21, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 3,749 | $97.94 | $367K@ $97.94 | 0 | Form 4 |
| Jan 21, 2026 | PVLAChief Operating Officer | Open-market saleCode S · direct | 553 | $95.49 | $53K@ $95.49 | 3,749 | Form 4 |
| Jan 21, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,148 | $9.08 | $20K@ $9.08 | 4,302 | Form 4 |
| Jan 21, 2026 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,154 | $7.14 | $15K@ $7.14 | 2,154 | Form 4 |
| Dec 17, 2025 | PVLAChief Operating Officer | Open-market saleCode S · direct | 4,302 | $96.47 | $415K@ $96.47 | 0 | Form 4 |
| Dec 17, 2025 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,148 | $9.08 | $20K@ $9.08 | 4,302 | Form 4 |
| Dec 17, 2025 | PVLAChief Operating Officer | Option exerciseCode M · direct | 2,154 | $7.14 | $15K@ $7.14 | 2,154 | Form 4 |