| Sep 15, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 200 | $106.77 | $21K@ $106.77 | 69,177 | Form 4 |
| Sep 15, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 2,379 | $105.97 | $252K@ $105.97 | 69,377 | Form 4 |
| Sep 15, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 1,700 | $105.00 | $179K@ $105.00 | 71,756 | Form 4 |
| Sep 14, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 2,039 | $111.83 | $228K@ $111.83 | 73,456 | Form 4 |
| Sep 11, 2026 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 4,434 | $119.76 | $531K@ $119.76 | 75,495 | Form 4 |
| Sep 11, 2026 | LSCCSVP, R&D | Grant or awardCode A · direct | 8,713 | — | — | 79,929 | Form 4 |
| Sep 11, 2026 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 869 | $119.76 | $104K@ $119.76 | 71,216 | Form 4 |
| Aug 31, 2026 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 654 | $115.34 | $75K@ $115.34 | 72,085 | Form 4 |
| Aug 16, 2026 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 593 | $130.46 | $77K@ $130.46 | 72,739 | Form 4 |
| Jul 10, 2026 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 504 | $137.44 | $69K@ $137.44 | 73,332 | Form 4 |
| Jun 30, 2026 | LSCCSVP, R&D | Option exerciseCode M · direct | 317 | $66.85 | $21K@ $66.85 | 73,836 | Form 4 |
| Jun 12, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 2,039 | $142.89 | $291K@ $142.89 | 73,519 | Form 4 |
| Jun 11, 2026 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 868 | $142.86 | $124K@ $142.86 | 75,558 | Form 4 |
| May 31, 2026 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 653 | $147.08 | $96K@ $147.08 | 76,426 | Form 4 |
| May 20, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 955 | $138.65 | $132K@ $138.65 | 77,079 | Form 4 |
| May 20, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 1,100 | $136.70 | $150K@ $136.70 | 79,134 | Form 4 |
| May 20, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 1,700 | $135.53 | $230K@ $135.53 | 80,234 | Form 4 |
| May 20, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 1,900 | $134.66 | $256K@ $134.66 | 81,934 | Form 4 |
| May 20, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 3,700 | $133.55 | $494K@ $133.55 | 83,834 | Form 4 |
| May 20, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 1,500 | $132.44 | $199K@ $132.44 | 87,534 | Form 4 |
| May 20, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 900 | $131.39 | $118K@ $131.39 | 89,034 | Form 4 |
| May 20, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 800 | $130.43 | $104K@ $130.43 | 89,934 | Form 4 |
| May 20, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 300 | $129.01 | $39K@ $129.01 | 90,734 | Form 4 |
| May 20, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 200 | $127.05 | $25K@ $127.05 | 91,034 | Form 4 |
| May 16, 2026 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 593 | $120.11 | $71K@ $120.11 | 91,234 | Form 4 |
| Apr 9, 2026 | LSCCSVP, R&D | Grant or awardCode A · direct | 11,869 | — | — | 91,827 | Form 4 |
| Mar 11, 2026 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 868 | $90.80 | $79K@ $90.80 | 79,958 | Form 4 |
| Mar 10, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 2,366 | $92.41 | $219K@ $92.41 | 80,826 | Form 4 |
| Mar 9, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 1,331 | $90.63 | $121K@ $90.63 | 83,192 | Form 4 |
| Mar 9, 2026 | LSCCSVP, R&D | Grant or awardCode A · direct | 3,697 | — | — | 84,523 | Form 4 |
| Feb 28, 2026 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 1,842 | $95.62 | $176K@ $95.62 | 80,826 | Form 4 |
| Feb 17, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 685 | $95.44 | $65K@ $95.44 | 82,668 | Form 4 |
| Feb 16, 2026 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 481 | $97.63 | $47K@ $97.63 | 83,353 | Form 4 |
| Feb 12, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 100 | $107.30 | $11K@ $107.30 | 83,834 | Form 4 |
| Feb 12, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 200 | $103.71 | $21K@ $103.71 | 84,834 | Form 4 |
| Feb 12, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 300 | $102.18 | $31K@ $102.18 | 85,034 | Form 4 |
| Feb 12, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 400 | $100.86 | $40K@ $100.86 | 85,334 | Form 4 |
| Feb 12, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 1,537 | $99.94 | $154K@ $99.94 | 85,734 | Form 4 |
| Feb 12, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 800 | $99.04 | $79K@ $99.04 | 87,271 | Form 4 |
| Feb 12, 2026 | LSCCSVP, R&D | Open-market saleCode S · direct | 700 | $97.51 | $68K@ $97.51 | 88,071 | Form 4 |
| Dec 17, 2025 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 15,437 | $71.86 | $1.1M@ $71.86 | 88,771 | Form 4 |
| Dec 12, 2025 | LSCCSVP, R&D | Open-market saleCode S · direct | 839 | $78.09 | $66K@ $78.09 | 104,208 | Form 4 |
| Dec 11, 2025 | LSCCSVP, R&D | Shares withheld for tax or exercise priceCode F · direct | 866 | $79.36 | $69K@ $79.36 | 105,047 | Form 4 |