| Aug 31, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 10,000 | $23.26 | $233K@ $23.26 | 68,555 | Form 4 |
| Jul 30, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 14,000 | $23.26 | $326K@ $23.26 | 72,555 | Form 4 |
| Jul 1, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 15,000 | $23.26 | $349K@ $23.26 | 73,555 | Form 4 |
| Jun 1, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 15,000 | $23.26 | $349K@ $23.26 | 73,555 | Form 4 |
| May 5, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 11,333 | $39.13 | $443K@ $39.13 | 69,888 | Form 4 |
| May 1, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 15,857 | $37.63 | $597K@ $37.63 | 74,412 | Form 4 |
| Apr 30, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 15,000 | $23.26 | $349K@ $23.26 | 73,555 | Form 4 |
| Apr 15, 2026 | CYTKEVP, Chief Commercial Officer | Open-market saleCode S · direct | 7,449 | $66.02 | $492K@ $66.02 | 58,555 | Form 4 |
| Mar 31, 2026 | CYTKEVP, Chief Commercial Officer | Open-market saleCode S · direct | 3,639 | $65.00 | $237K@ $65.00 | 66,004 | Form 4 |
| Mar 18, 2026 | CYTKEVP, Chief Commercial Officer | Open-market saleCode S · direct | 1,930 | $62.07 | $120K@ $62.07 | 78,185 | Form 4 |
| Mar 17, 2026 | CYTKEVP, Chief Commercial Officer | Open-market saleCode S · direct | 2,916 | $62.15 | $181K@ $62.15 | 71,573 | Form 4 |
| Mar 17, 2026 | CYTKEVP, Chief Commercial Officer | Open-market saleCode S · direct | 5,626 | $62.15 | $350K@ $62.15 | 74,489 | Form 4 |
| Mar 16, 2026 | CYTKEVP, Chief Commercial Officer | Open-market saleCode S · direct | 1,709 | $61.03 | $104K@ $61.03 | 46,149 | Form 4 |
| Mar 15, 2026 | CYTKEVP, Chief Commercial Officer | Grant or awardCode A · direct | 29,480 | — | — | 29,480 | Form 4 |
| Mar 15, 2026 | CYTKEVP, Chief Commercial Officer | Grant or awardCode A · direct | 1,665 | — | — | 1,665 | Form 4 |
| Mar 15, 2026 | CYTKEVP, Chief Commercial Officer | Grant or awardCode A · direct | 13,320 | — | — | 81,824 | Form 4 |
| Mar 15, 2026 | CYTKEVP, Chief Commercial Officer | Grant or awardCode A · direct | 20,646 | — | — | 68,504 | Form 4 |
| Mar 9, 2026 | CYTKEVP, Chief Commercial Officer | Open-market saleCode S · direct | 2,582 | $60.72 | $157K@ $60.72 | 47,858 | Form 4 |
| Mar 5, 2026 | CYTKEVP, Chief Commercial Officer | Open-market saleCode S · direct | 15,000 | $61.87 | $928K@ $61.87 | 61,440 | Form 4 |
| Mar 5, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 11,000 | $39.13 | $430K@ $39.13 | 76,440 | Form 4 |
| Mar 2, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 886 | $37.63 | $33K@ $37.63 | 51,326 | Form 4 |
| Feb 5, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 15,000 | $23.26 | $349K@ $23.26 | 65,440 | Form 4 |
| Feb 2, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 886 | $37.63 | $33K@ $37.63 | 51,326 | Form 4 |
| Jan 5, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 15,000 | $23.26 | $349K@ $23.26 | 65,440 | Form 4 |
| Jan 2, 2026 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 885 | $37.63 | $33K@ $37.63 | 51,325 | Form 4 |
| Jan 2, 2026 | CYTKEVP, Chief Commercial Officer | Open-market saleCode S · direct | 913 | $62.09 | $57K@ $62.09 | 50,440 | Form 4 |
| Dec 29, 2025 | CYTKEVP, Chief Commercial Officer | Open-market saleCode S · direct | 1,809 | $62.44 | $113K@ $62.44 | 51,353 | Form 4 |
| Dec 22, 2025 | CYTKEVP, Chief Commercial Officer | Shares withheld for tax or exercise priceCode F · direct | 675 | $62.72 | $42K@ $62.72 | 53,162 | Form 4 |
| Dec 22, 2025 | CYTKEVP, Chief Commercial Officer | Grant or awardCode A · direct | 1,588 | — | — | 53,837 | Form 4 |
| Dec 22, 2025 | CYTKEVP, Chief Commercial Officer | Grant or awardCode A · direct | 1,589 | — | — | 52,249 | Form 4 |
| Dec 8, 2025 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 1,042 | $39.13 | $41K@ $39.13 | 51,702 | Form 4 |
| Dec 5, 2025 | CYTKEVP, Chief Commercial Officer | Open-market saleCode S · direct | 52,486 | $65.95 | $3.5M@ $65.95 | 50,660 | Form 4 |
| Dec 5, 2025 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 10,628 | $37.63 | $400K@ $37.63 | 103,146 | Form 4 |
| Dec 5, 2025 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 15,858 | $37.63 | $597K@ $37.63 | 92,518 | Form 4 |
| Dec 5, 2025 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 11,000 | $39.13 | $430K@ $39.13 | 76,660 | Form 4 |
| Dec 5, 2025 | CYTKEVP, Chief Commercial Officer | Option exerciseCode M · direct | 15,000 | $23.26 | $349K@ $23.26 | 65,660 | Form 4 |
| Dec 3, 2025 | CYTKEVP, Chief Commercial Officer | Shares withheld for tax or exercise priceCode F · direct | 1,368 | $65.02 | $89K@ $65.02 | 50,660 | Form 4 |