Wave Life Sciences, Inc. (WVE) — Institutional Holders, Q2 2026
241 institutional investment managers reported a WVE position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $1.1B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
WVE in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- BlackRockAdded · +5,085,049 sh+$29.5M
- READYSTATE ASSET MANAGEMENTNew · +4,727,139 sh+$27.5M
- Qube Research & Technologies LtdAdded · +2,620,076 sh+$15.2M
- TWO SIGMA INVESTMENTSAdded · +1,829,571 sh+$10.6M
- DIMENSIONAL FUND ADVISORSNew · +1,707,809 sh+$9.9M
Biggest sellers
- PRICE T ROWE ASSOCIATESTrimmed · -6,898,083 sh-$40.1M
- FEDERATED HERMESTrimmed · -3,851,223 sh-$22.4M
- Siren, L.L.C.Sold out · -2,450,000 sh-$14.2M
- First Light Asset ManagementSold out · -1,843,968 sh-$10.7M
- CITADEL ADVISORSTrimmed · -1,722,702 sh-$10.0M
WVE 13F holders ranked 1–100 of 241
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P.#1 · 26,975,505 sh | 26,975,505 | $156.7M | 1.36% | 0.0% |
| 2 | BlackRock#2 · 19,202,461 sh | 19,202,461 | $111.6M | <0.01% | +36.0% |
| 3 | GSK plc#3 · 18,245,691 sh | 18,245,691 | $106.0M | 17.60% | 0.0% |
| 4 | MAVERICK CAPITAL LTD#4 · 10,278,115 sh | 10,278,115 | $59.7M | 0.53% | +1.1% |
| 5 | DRIEHAUS CAPITAL MANAGEMENT#5 · 5,443,143 sh | 5,443,143 | $31.6M | 0.18% | +0.2% |
| 6 | PRIMECAP MANAGEMENT#6 · 5,354,622 sh | 5,354,622 | $31.1M | 0.02% | +10.8% |
| 7 | 683 Capital Management#7 · 4,950,000 sh | 4,950,000 | $28.8M | 1.41% | +1.0% |
| 8 | FMR#8 · 4,922,477 sh | 4,922,477 | $28.6M | <0.01% | -5.2% |
| 9 | STATE STREET#9 · 4,839,317 sh | 4,839,317 | $28.1M | <0.01% | +31.7% |
| 10 | READYSTATE ASSET MANAGEMENT#10 · 4,727,139 sh | 4,727,139 | $27.5M | 0.02% | New |
| 11 | M28 Capital Management#11 · 4,588,284 sh | 4,588,284 | $26.7M | 56.53% | 0.0% |
| 12 | GEODE CAPITAL MANAGEMENT#12 · 3,869,998 sh | 3,869,998 | $22.5M | <0.01% | +8.1% |
| 13 | TWO SIGMA INVESTMENTS#13 · 3,707,686 sh | 3,707,686 | $21.5M | 0.02% | +97.4% |
| 14 | ALGERT GLOBAL#14 · 2,817,615 sh | 2,817,615 | $16.4M | 0.19% | +114.2% |
| 15 | Qube Research & Technologies Ltd#15 · 2,776,000 sh | 2,776,000 | $16.1M | 0.01% | +1680.4% |
| 16 | Squarepoint Ops#16 · 2,541,442 sh | 2,541,442 | $14.8M | 0.02% | +73.8% |
| 17 | MORGAN STANLEY#17 · 2,422,705 sh | 2,422,705 | $14.1M | <0.01% | +78.0% |
| 18 | VANGUARD PORTFOLIO MANAGEMENT#18 · 2,110,751 sh | 2,110,751 | $12.3M | <0.01% | +79.5% |
| 19 | PFIZER#19 · 1,875,000 sh | 1,875,000 | $10.9M | 6.42% | 0.0% |
| 20 | MILLENNIUM MANAGEMENT#20 · 1,811,282 sh | 1,811,282 | $10.5M | <0.01% | +86.3% |
| 21 | PRICE T ROWE ASSOCIATES#21 · 1,806,467 sh | 1,806,467 | $10.5M | <0.01% | -79.2% |
| 22 | D. E. Shaw#22 · 1,772,228 sh | 1,772,228 | $10.3M | <0.01% | +2351.0% |
| 23 | VANGUARD CAPITAL MANAGEMENT#23 · 1,751,403 sh | 1,751,403 | $10.2M | <0.01% | +8.7% |
| 24 | SCHRODER INVESTMENT MANAGEMENT GROUP#24 · 1,746,643 sh | 1,746,643 | $9.9M | <0.01% | +21.2% |
| 25 | DIMENSIONAL FUND ADVISORS#25 · 1,707,809 sh | 1,707,809 | $9.9M | <0.01% | New |
| 26 | RENAISSANCE TECHNOLOGIES#26 · 1,704,520 sh | 1,704,520 | $9.9M | 0.01% | +185.4% |
| 27 | AQR CAPITAL MANAGEMENT#27 · 1,648,045 sh | 1,648,045 | $9.6M | <0.01% | +265.3% |
| 28 | GOLDMAN SACHS GROUP#28 · 1,622,342 sh | 1,622,342 | $9.4M | <0.01% | +17.3% |
| 29 | Point72 Asset Management, L.P.#29 · 1,484,989 sh | 1,484,989 | $8.6M | <0.01% | New |
| 30 | FEDERATED HERMES#30 · 1,466,234 sh | 1,466,234 | $8.5M | 0.01% | -72.4% |
| 31 | RTW INVESTMENTS#31 · 1,350,000 sh | 1,350,000 | $7.8M | 0.07% | 0.0% |
| 32 | NORTHERN#32 · 1,253,500 sh | 1,253,500 | $7.3M | <0.01% | +5.4% |
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT#33 · 1,224,445 sh | 1,224,445 | $7.1M | <0.01% | +3.8% |
| 34 | EMERALD ADVISERS#34 · 1,223,965 sh | 1,223,965 | $7.1M | 0.17% | -3.0% |
| 35 | MARSHALL WACE, LLP#35 · 999,533 sh | 999,533 | $5.8M | <0.01% | -44.2% |
| 36 | Pictet Asset Management Holding SA#36 · 917,409 sh | 917,409 | $5.3M | <0.01% | -20.2% |
| 37 | VANGUARD FIDUCIARY#37 · 887,677 sh | 887,677 | $5.2M | <0.01% | +1.0% |
| 38 | abrdn plc#38 · 876,458 sh | 876,458 | $5.1M | <0.01% | +59.4% |
| 39 | EMERALD MUTUAL FUND ADVISERS#39 · 847,999 sh | 847,999 | $4.9M | 0.17% | +4.1% |
| 40 | BAKER BROS. ADVISORS#40 · 822,638 sh | 822,638 | $4.8M | 0.02% | 0.0% |
| 41 | BNP PARIBAS FINANCIAL MARKETS#41 · 811,057 sh | 811,057 | $4.7M | <0.01% | +188.6% |
| 42 | CAPITAL FUND MANAGEMENT S.A.#42 · 734,746 sh | 734,746 | $4.3M | 0.02% | +300.8% |
| 43 | SPHERA FUNDS MANAGEMENT LTD.#43 · 638,272 sh | 638,272 | $3.7M | 0.48% | +16.4% |
| 44 | JPMORGAN CHASE#44 · 618,172 sh | 618,172 | $3.5M | <0.01% | -7.8% |
| 45 | Y-Intercept (Hong Kong) Ltd#45 · 610,094 sh | 610,094 | $3.5M | — | +288.6% |
| 46 | Susquehanna Portfolio Strategies#46 · 608,194 sh | 608,194 | $3.5M | 0.06% | +210.6% |
| 47 | TANG CAPITAL MANAGEMENT#47 · 600,000 sh | 600,000 | $3.5M | 0.16% | 0.0% |
| 48 | Walleye Capital#48 · 585,453 sh | 585,453 | $3.4M | 0.01% | +18.6% |
| 49 | Nuveen#49 · 549,282 sh | 549,282 | $3.2M | <0.01% | -16.5% |
| 50 | BANK OF AMERICA#50 · 517,054 sh | 517,054 | $3.0M | <0.01% | +118.4% |
| 51 | Man Group plc#51 · 505,456 sh | 505,456 | $2.9M | <0.01% | +689.3% |
| 52 | UBS Group AG#52 · 505,237 sh | 505,237 | $2.9M | <0.01% | -6.3% |
| 53 | CITADEL ADVISORS#53 · 480,154 sh | 480,154 | $2.8M | <0.01% | -78.2% |
| 54 | Jump Financial#54 · 452,502 sh | 452,502 | $2.6M | 0.02% | +25.7% |
| 55 | XTX Topco Ltd#55 · 439,933 sh | 439,933 | $2.6M | 0.03% | +300.4% |
| 56 | KENNEDY CAPITAL MANAGEMENT#56 · 429,121 sh | 429,121 | $2.5M | 0.04% | -17.4% |
| 57 | WELLINGTON MANAGEMENT GROUP LLP#57 · 423,005 sh | 423,005 | $2.5M | <0.01% | +13.2% |
| 58 | Bank of New York Mellon#58 · 416,579 sh | 416,579 | $2.4M | <0.01% | +15.3% |
| 59 | Universal- Beteiligungs- und Servicegesellschaft mbH#59 · 408,894 sh | 408,894 | $2.4M | <0.01% | -1.6% |
| 60 | Connor, Clark & Lunn Investment Management Ltd.#60 · 406,478 sh | 406,478 | $2.4M | <0.01% | -34.9% |
| 61 | Trexquant Investment#61 · 380,169 sh | 380,169 | $2.2M | 0.01% | -65.1% |
| 62 | HSBC PLC#62 · 370,449 sh | 370,449 | $2.2M | <0.01% | New |
| 63 | Woodline Partners#63 · 350,531 sh | 350,531 | $2.0M | <0.01% | 0.0% |
| 64 | Ishara Investments#64 · 328,000 sh | 328,000 | $1.9M | 1.40% | New |
| 65 | BARCLAYS PLC#65 · 309,580 sh | 309,580 | $1.8M | <0.01% | +63.1% |
| 66 | SUSQUEHANNA INTERNATIONAL GROUP, LLP#66 · 299,400 sh | 299,400 | $1.7M | <0.01% | +15.2% |
| 67 | Russell Investments Group, Ltd.#67 · 276,818 sh | 276,818 | $1.6M | <0.01% | +376.8% |
| 68 | PLATINUM INVESTMENT MANAGEMENT LTD#68 · 275,269 sh | 275,269 | $1.6M | 0.39% | 0.0% |
| 69 | Swiss National Bank#69 · 260,600 sh | 260,600 | $1.5M | <0.01% | +18.6% |
| 70 | ExodusPoint Capital Management#70 · 251,072 sh | 251,072 | $1.5M | <0.01% | New |
| 71 | Privium Fund Management B.V.#71 · 241,010 sh | 241,010 | $1.4M | 0.26% | 0.0% |
| 72 | F/m Investments#72 · 235,085 sh | 235,085 | $1.4M | 0.07% | +42.5% |
| 73 | MIRAE ASSET GLOBAL ETFS Ltd.#73 · 230,484 sh | 230,484 | $1.3M | <0.01% | +53.3% |
| 74 | Newtyn Management#74 · 215,000 sh | 215,000 | $1.2M | 0.16% | -28.3% |
| 75 | Invesco Ltd.#75 · 200,306 sh | 200,306 | $1.2M | <0.01% | +0.3% |
| 76 | TD ASSET MANAGEMENT#76 · 194,026 sh | 194,026 | $1.1M | <0.01% | -42.7% |
| 77 | ALPS ADVISORS#77 · 193,766 sh | 193,766 | $1.1M | <0.01% | New |
| 78 | RHUMBLINE ADVISERS#78 · 193,667 sh | 193,667 | $1.1M | <0.01% | +15.6% |
| 79 | Sofinnova Ventures#79 · 189,253 sh | 189,253 | $1.1M | 0.06% | 0.0% |
| 80 | GSA CAPITAL PARTNERS LLP#80 · 185,959 sh | 185,959 | $1.1M | 0.07% | -34.2% |
| 81 | Elmind Capital#81 · 177,846 sh | 177,846 | $1.0M | 0.26% | 0.0% |
| 82 | Duquesne Family Office#82 · 173,000 sh | 173,000 | $1.0M | 0.02% | 0.0% |
| 83 | ADAR1 Capital Management#83 · 160,000 sh | 160,000 | $929.6K | 0.04% | +256.3% |
| 84 | ALLIANCEBERNSTEIN L.P.#84 · 124,730 sh | 124,730 | $904.3K | <0.01% | -0.3% |
| 85 | WELLS FARGO & COMPANY#85 · 154,211 sh | 154,211 | $896.0K | <0.01% | +13.2% |
| 86 | Burkehill Global Management#86 · 150,000 sh | 150,000 | $871.5K | 0.03% | 0.0% |
| 87 | DEUTSCHE BANK AG\#87 · 147,101 sh | 147,101 | $854.7K | <0.01% | +28.9% |
| 88 | BOOTHBAY FUND MANAGEMENT#88 · 145,000 sh | 145,000 | $842.5K | 0.01% | -9.6% |
| 89 | MANUFACTURERS LIFE INSURANCE COMPANY, THE#89 · 144,009 sh | 144,009 | $836.7K | <0.01% | -40.2% |
| 90 | STATE OF WISCONSIN INVESTMENT BOARD#90 · 143,026 sh | 143,026 | $831.0K | <0.01% | +32.2% |
| 91 | CITIGROUP#91 · 125,051 sh | 125,051 | $726.5K | <0.01% | -75.1% |
| 92 | James J. Burns & Company#92 · 114,800 sh | 114,800 | $667.0K | — | 0.0% |
| 93 | IEQ CAPITAL#93 · 106,446 sh | 106,446 | $618.5K | <0.01% | +372.4% |
| 94 | Cetera Investment Advisers#94 · 104,878 sh | 104,878 | $609.3K | <0.01% | New |
| 95 | LOS ANGELES CAPITAL MANAGEMENT#95 · 104,705 sh | 104,705 | $608.3K | <0.01% | New |
| 96 | VANGUARD ASSET MANAGEMENT, Ltd#96 · 103,995 sh | 103,995 | $604.2K | <0.01% | +39.2% |
| 97 | Mariner#97 · 102,195 sh | 102,195 | $593.8K | <0.01% | +389.2% |
| 98 | Bridgefront Capital#98 · 101,454 sh | 101,454 | $589.4K | 0.16% | +735.3% |
| 99 | Legal & General Group Plc#99 · 89,531 sh | 89,531 | $520.2K | <0.01% | +13.3% |
| 100 | MetLife Investment Management#100 · 88,397 sh | 88,397 | $513.6K | <0.01% | +15.9% |
Funds that sold out of WVE in Q2 2026 (40)
Held WVE at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| Siren, L.L.C.2,450,000 sh | 2,450,000 | $17.8M |
| First Light Asset Management1,843,968 sh | 1,843,968 | $13.4M |
| Affinity Asset Advisors1,401,727 sh | 1,401,727 | $10.2M |
| ADAGE CAPITAL PARTNERS GP, L.L.C.1,000,000 sh | 1,000,000 | $7.3M |
| Kynam Capital Management965,193 sh | 965,193 | $7.0M |
| KENNEDY CAPITAL MANAGEMENT519,768 sh | 519,768 | $3.8M |
| Aquatic Capital Management323,573 sh | 323,573 | $2.3M |
| HRT FINANCIAL321,376 sh | 321,376 | $2.3M |
| VOLORIDGE INVESTMENT MANAGEMENT288,502 sh | 288,502 | $2.1M |
| MOODY ALDRICH PARTNERS272,533 sh | 272,533 | $2.0M |
| Itau Unibanco Holding S.A.102,000 sh | 102,000 | $1.7M |
| BALYASNY ASSET MANAGEMENT L.P.211,074 sh | 211,074 | $1.5M |
| Scientech Research200,331 sh | 200,331 | $1.5M |
| TWINBEECH CAPITAL145,825 sh | 145,825 | $1.1M |
| Advisory Services Network144,950 sh | 144,950 | $1.1M |
| FRED ALGER MANAGEMENT139,218 sh | 139,218 | $1.0M |
| TUDOR INVESTMENT ET AL97,900 sh | 97,900 | $709.8K |
| Virtu Financial76,779 sh | 76,779 | $557.0K |
| J. Goldman53,896 sh | 53,896 | $390.7K |
| GLENMEDE NA44,241 sh | 44,241 | $320.7K |
| AMERIPRISE FINANCIAL40,374 sh | 40,374 | $292.7K |
| ENVESTNET ASSET MANAGEMENT38,546 sh | 38,546 | $279.5K |
| Private Advisor Group22,100 sh | 22,100 | $160.2K |
| GABELLI FUNDS17,500 sh | 17,500 | $126.9K |
| Walleye Trading16,288 sh | 16,288 | $118.1K |
| LPL Financial10,373 sh | 10,373 | $75.2K |
| QUADRANT CAPITAL GROUP4,792 sh | 4,792 | $66.3K |
| GROUP ONE TRADING, L.P.6,260 sh | 6,260 | $45.4K |
| Hudson Bay Capital Management6,200 sh | 6,200 | $45.0K |
| Bellevue Group AG5,261 sh | 5,261 | $38.1K |
| KBC Group NV3,297 sh | 3,297 | $24.0K |
| MAI Capital Management1,341 sh | 1,341 | $9.7K |
| Kemnay Advisory Services1,201 sh | 1,201 | $8.7K |
| SMA Capital433 sh | 433 | $3.1K |
| Essential Partners166 sh | 166 | $1.2K |
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION160 sh | 160 | $1.2K |
| Golden State Equity Partners90 sh | 90 | $652.00 |
| Parkside Financial Bank72 sh | 72 | $522.00 |
| Silicon Valley Capital Partners25 sh | 25 | $181.00 |
| TWIN PEAKS WEALTH ADVISORS5 sh | 5 | $36.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.