SOPHiA GENETICS SA (SOPH) — Institutional Holders, Q2 2026
72 institutional investment managers reported a SOPH position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $212.5M. Every filer is listed below, ranked by position value. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
SOPH in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- AIGH Capital ManagementNew · +3,954,194 sh+$22.8M
- AMERIPRISE FINANCIALNew · +2,216,752 sh+$12.8M
- AWM Investment CompanyNew · +1,700,000 sh+$9.8M
- ROYCE & ASSOCIATESAdded · +1,565,424 sh+$9.0M
- SILVERCREST ASSET MANAGEMENT GROUPNew · +1,428,470 sh+$8.2M
Biggest sellers
- Soleus Capital Management, L.P.Trimmed · -285,000 sh-$1.6M
- SEI INVESTMENTSTrimmed · -192,843 sh-$1.1M
- FEDERATED HERMESTrimmed · -48,018 sh-$277.1K
- Rathbones Group PLCTrimmed · -37,000 sh-$213.5K
- ESSEX INVESTMENT MANAGEMENTTrimmed · -29,381 sh-$169.5K
SOPH 13F holders ranked 1–72 of 72
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | GENERATION INVESTMENT MANAGEMENT LLP#1 · 6,789,560 sh | 6,789,560 | $39.2M | 0.38% | 0.0% |
| 2 | AIGH Capital Management#2 · 3,954,194 sh | 3,954,194 | $22.8M | 1.44% | New |
| 3 | AKRE CAPITAL MANAGEMENT#3 · 3,719,140 sh | 3,719,140 | $21.5M | 0.42% | 0.0% |
| 4 | ROYCE & ASSOCIATES#4 · 3,381,736 sh | 3,381,736 | $19.5M | 0.16% | +86.2% |
| 5 | PRINCIPAL FINANCIAL GROUP#5 · 2,364,256 sh | 2,364,256 | $13.6M | <0.01% | +67.8% |
| 6 | AMERIPRISE FINANCIAL#6 · 2,216,752 sh | 2,216,752 | $12.8M | <0.01% | New |
| 7 | BANQUE PICTET & CIE SA#7 · 2,208,280 sh | 2,208,280 | $12.7M | — | 0.0% |
| 8 | AWM Investment Company#8 · 1,700,000 sh | 1,700,000 | $9.8M | 0.85% | New |
| 9 | Soleus Capital Management, L.P.#9 · 1,565,000 sh | 1,565,000 | $9.0M | 0.31% | -15.4% |
| 10 | SILVERCREST ASSET MANAGEMENT GROUP#10 · 1,428,470 sh | 1,428,470 | $8.2M | 0.05% | New |
| 11 | Alta Wealth Advisors#11 · 1,409,160 sh | 1,409,160 | $8.1M | 2.20% | 0.0% |
| 12 | KENNEDY CAPITAL MANAGEMENT#12 · 917,977 sh | 917,977 | $5.3M | 0.09% | -1.1% |
| 13 | Archon Capital Management#13 · 691,413 sh | 691,413 | $4.0M | 1.62% | +56.6% |
| 14 | ESSEX INVESTMENT MANAGEMENT#14 · 663,428 sh | 663,428 | $3.8M | — | -4.2% |
| 15 | Ensign Peak Advisors#15 · 444,654 sh | 444,654 | $2.6M | <0.01% | -0.1% |
| 16 | Hodges Capital Management#16 · 409,073 sh | 409,073 | $2.4M | 0.16% | -6.1% |
| 17 | Pictet & Cie (Europe) SA#17 · 255,200 sh | 255,200 | $1.5M | — | 0.0% |
| 18 | Legato Capital Management#18 · 223,230 sh | 223,230 | $1.3M | 0.11% | +3.2% |
| 19 | 1492 Capital Management#19 · 222,194 sh | 222,194 | $1.3M | 0.38% | -1.6% |
| 20 | EDMOND DE ROTHSCHILD HOLDING S.A.#20 · 200,004 sh | 200,004 | $1.2M | 0.02% | -1.6% |
| 21 | SEI INVESTMENTS#21 · 165,045 sh | 165,045 | $952.3K | <0.01% | -53.9% |
| 22 | Maven Securities LTD#22 · 150,000 sh | 150,000 | $865.5K | 0.02% | New |
| 23 | FEDERATED HERMES#23 · 141,992 sh | 141,992 | $819.3K | <0.01% | -25.3% |
| 24 | MILLENNIUM MANAGEMENT#24 · 138,409 sh | 138,409 | $798.6K | <0.01% | +1264.7% |
| 25 | RENAISSANCE TECHNOLOGIES#25 · 113,300 sh | 113,300 | $653.7K | <0.01% | +89.5% |
| 26 | Rathbones Group PLC#26 · 112,133 sh | 112,133 | $647.0K | <0.01% | -24.8% |
| 27 | JANE STREET GROUP#27 · 108,062 sh | 108,062 | $623.5K | <0.01% | New |
| 28 | Quadrature Capital Ltd#28 · 103,521 sh | 103,521 | $597.3K | <0.01% | New |
| 29 | GEODE CAPITAL MANAGEMENT#29 · 99,124 sh | 99,124 | $571.9K | 0.00% | +7.6% |
| 30 | Hennion & Walsh Asset Management#30 · 98,347 sh | 98,347 | $567.5K | — | New |
| 31 | UBS Group AG#31 · 81,444 sh | 81,444 | $469.9K | <0.01% | -11.7% |
| 32 | Silverberg Bernstein Capital Management#32 · 66,869 sh | 66,869 | $385.8K | — | +28.7% |
| 33 | TWO SIGMA INVESTMENTS#33 · 58,333 sh | 58,333 | $336.6K | <0.01% | +472.0% |
| 34 | XTX Topco Ltd#34 · 57,140 sh | 57,140 | $329.7K | <0.01% | New |
| 35 | Longaeva Partners L.P.#35 · 50,000 sh | 50,000 | $288.5K | <0.01% | New |
| 36 | Green Alpha Advisors#36 · 42,765 sh | 42,765 | $246.8K | — | -0.4% |
| 37 | StoneX Group#37 · 45,523 sh | 45,523 | $229.9K | <0.01% | New |
| 38 | CITADEL ADVISORS#38 · 38,497 sh | 38,497 | $222.1K | 0.00% | New |
| 39 | MORGAN STANLEY#39 · 37,497 sh | 37,497 | $216.4K | 0.00% | +61.8% |
| 40 | WESTFIELD CAPITAL MANAGEMENT#40 · 32,907 sh | 32,907 | $189.9K | <0.01% | New |
| 41 | Pathstone#41 · 32,203 sh | 32,203 | $184.8K | <0.01% | +2.3% |
| 42 | GOLDMAN SACHS GROUP#42 · 29,598 sh | 29,598 | $170.8K | 0.00% | -48.6% |
| 43 | HRT FINANCIAL#43 · 22,532 sh | 22,532 | $130.0K | <0.01% | New |
| 44 | FRANKLIN RESOURCES#44 · 22,405 sh | 22,405 | $129.3K | 0.00% | +3.9% |
| 45 | ACADIAN ASSET MANAGEMENT#45 · 22,600 sh | 22,600 | $129.0K | <0.01% | New |
| 46 | BANK OF AMERICA#46 · 22,300 sh | 22,300 | $128.7K | 0.00% | New |
| 47 | AXQ CAPITAL#47 · 20,592 sh | 20,592 | $118.8K | 0.01% | New |
| 48 | HEIGHTS CAPITAL MANAGEMENT#48 · 20,000 sh | 20,000 | $115.4K | 0.03% | New |
| 49 | Centiva Capital#49 · 18,869 sh | 18,869 | $108.9K | <0.01% | +50.4% |
| 50 | Persistent Asset Partners Ltd#50 · 18,807 sh | 18,807 | $108.5K | 0.03% | New |
| 51 | PRELUDE CAPITAL MANAGEMENT#51 · 15,596 sh | 15,596 | $90.0K | <0.01% | New |
| 52 | ENVESTNET ASSET MANAGEMENT#52 · 14,243 sh | 14,243 | $82.2K | 0.00% | New |
| 53 | Walleye Capital#53 · 11,543 sh | 11,543 | $66.6K | <0.01% | New |
| 54 | Cetera Investment Advisers#54 · 11,404 sh | 11,404 | $65.8K | <0.01% | New |
| 55 | PERKINS CAPITAL MANAGEMENT#55 · 10,500 sh | 10,500 | $60.6K | 0.05% | 0.0% |
| 56 | First Dallas Securities#56 · 10,000 sh | 10,000 | $57.7K | 0.02% | 0.0% |
| 57 | ASSETMARK#57 · 8,836 sh | 8,836 | $51.0K | — | +87.6% |
| 58 | US BANCORP \DE\#58 · 8,618 sh | 8,618 | $49.7K | <0.01% | New |
| 59 | Zurcher Kantonalbank (Zurich Cantonalbank)#59 · 5,112 sh | 5,112 | $29.5K | <0.01% | +36.1% |
| 60 | BlackRock#60 · 5,086 sh | 5,086 | $29.3K | 0.00% | 0.0% |
| 61 | BARCLAYS PLC#61 · 2,677 sh | 2,677 | $15.4K | 0.00% | New |
| 62 | Compagnie Lombard Odier SCmA#62 · 1,055 sh | 1,055 | $6.1K | <0.01% | 0.0% |
| 63 | NBC SECURITIES#63 · 987 sh | 987 | $5.7K | — | 0.0% |
| 64 | Parallel Advisors#64 · 900 sh | 900 | $5.2K | <0.01% | 0.0% |
| 65 | ROYAL BANK OF CANADA#65 · 719 sh | 719 | $4.0K | 0.00% | -96.3% |
| 66 | CoreCap Advisors#66 · 490 sh | 490 | $2.8K | — | New |
| 67 | Integrated Wealth Concepts#67 · 122 sh | 122 | $703.00 | 0.00% | New |
| 68 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#68 · 77 sh | 77 | $444.00 | 0.00% | 0.0% |
| 69 | Russell Investments Group, Ltd.#69 · 59 sh | 59 | $340.00 | 0.00% | 0.0% |
| 70 | HARBOUR INVESTMENTS#70 · 56 sh | 56 | $321.00 | 0.00% | -8.2% |
| 71 | Caitong International Asset Management , Ltd#71 · 47 sh | 47 | $271.00 | 0.00% | +4600.0% |
| 72 | SBI Securities , Ltd.#72 · 33 sh | 33 | $190.00 | — | -26.7% |
Funds that sold out of SOPH in Q2 2026 (4)
Held SOPH at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP13,156 sh | 13,156 | $65.1K |
| OSAIC1,000 sh | 1,000 | $5.0K |
| Federation des caisses Desjardins du Quebec700 sh | 700 | $3.5K |
| JPMORGAN CHASE206 sh | 206 | $966.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.