Silence Therapeutics plc (SLN) — Institutional Holders, Q2 2026
72 institutional investment managers reported a SLN position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $238.7M. Every filer is listed below, ranked by position value. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
SLN in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- Soleus Capital Management, L.P.New · +630,000 sh+$6.9M
- BALYASNY ASSET MANAGEMENT L.P.New · +610,980 sh+$6.7M
- Siren, L.L.C.Added · +400,000 sh+$4.4M
- AMERIPRISE FINANCIALNew · +370,052 sh+$4.1M
- MORGAN STANLEYAdded · +337,686 sh+$3.7M
Biggest sellers
- Nantahala Capital ManagementTrimmed · -800,000 sh-$8.8M
- GREAT POINT PARTNERSTrimmed · -570,489 sh-$6.3M
- Jones Hill CapitalSold out · -301,604 sh-$3.3M
- SG Americas SecuritiesTrimmed · -274,642 sh-$3.0M
- MILLENNIUM MANAGEMENTTrimmed · -164,912 sh-$1.8M
SLN 13F holders ranked 1–72 of 72
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | Siren, L.L.C.#1 · 3,311,438 sh | 3,311,438 | $36.4M | 0.74% | +13.7% |
| 2 | TCG Crossover Management#2 · 3,033,560 sh | 3,033,560 | $33.3M | 0.80% | 0.0% |
| 3 | Redmile Group#3 · 2,164,777 sh | 2,164,777 | $23.8M | 1.60% | 0.0% |
| 4 | Nantahala Capital Management#4 · 1,346,731 sh | 1,346,731 | $14.8M | 0.49% | -37.3% |
| 5 | CITADEL ADVISORS#5 · 1,329,625 sh | 1,329,625 | $14.6M | <0.01% | +7.7% |
| 6 | Nextech Invest, Ltd.#6 · 952,400 sh | 952,400 | $10.5M | 0.50% | 0.0% |
| 7 | MILLENNIUM MANAGEMENT#7 · 909,279 sh | 909,279 | $10.0M | <0.01% | -15.4% |
| 8 | TFG Asset Management GP Ltd#8 · 764,256 sh | 764,256 | $8.4M | 1.32% | +21.3% |
| 9 | Soleus Capital Management, L.P.#9 · 630,000 sh | 630,000 | $6.9M | 0.24% | New |
| 10 | BALYASNY ASSET MANAGEMENT L.P.#10 · 610,980 sh | 610,980 | $6.7M | <0.01% | New |
| 11 | 5AM Venture Management#11 · 476,200 sh | 476,200 | $5.2M | 1.82% | 0.0% |
| 12 | GREAT POINT PARTNERS#12 · 450,000 sh | 450,000 | $4.9M | 0.93% | -55.9% |
| 13 | MORGAN STANLEY#13 · 403,172 sh | 403,172 | $4.4M | <0.01% | +515.7% |
| 14 | AMERIPRISE FINANCIAL#14 · 370,052 sh | 370,052 | $4.1M | <0.01% | New |
| 15 | JANE STREET GROUP#15 · 369,151 sh | 369,151 | $4.1M | <0.01% | +265.8% |
| 16 | ADAR1 Capital Management#16 · 338,373 sh | 338,373 | $3.7M | 0.17% | +96.5% |
| 17 | SummitTX Capital, L.P.#17 · 326,648 sh | 326,648 | $3.6M | 0.09% | New |
| 18 | Schonfeld Strategic Advisors#18 · 269,348 sh | 269,348 | $3.0M | 0.01% | New |
| 19 | UBS Group AG#19 · 243,152 sh | 243,152 | $2.7M | <0.01% | -1.5% |
| 20 | Ishara Investments#20 · 55,350 sh | 55,350 | $2.4M | 1.79% | -60.6% |
| 21 | BlackRock#21 · 219,917 sh | 219,917 | $2.4M | 0.00% | +7.4% |
| 22 | BANK OF MONTREAL#22 · 201,734 sh | 201,734 | $2.2M | <0.01% | -0.6% |
| 23 | BOOTHBAY FUND MANAGEMENT#23 · 198,347 sh | 198,347 | $2.2M | 0.03% | -5.1% |
| 24 | Propel Bio Management#24 · 191,733 sh | 191,733 | $2.1M | 1.10% | New |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP#25 · 184,519 sh | 184,519 | $2.0M | <0.01% | +60.1% |
| 26 | FRED ALGER MANAGEMENT#26 · 177,000 sh | 177,000 | $1.9M | <0.01% | New |
| 27 | Ikarian Capital#27 · 830,784 sh | 830,784 | $1.8M | 0.20% | -4.0% |
| 28 | Qube Research & Technologies Ltd#28 · 163,945 sh | 163,945 | $1.8M | <0.01% | +56.8% |
| 29 | Caption Management#29 · 162,476 sh | 162,476 | $1.8M | <0.01% | New |
| 30 | BNP PARIBAS FINANCIAL MARKETS#30 · 158,950 sh | 158,950 | $1.7M | <0.01% | +7.6% |
| 31 | GOLDMAN SACHS GROUP#31 · 155,929 sh | 155,929 | $1.7M | <0.01% | +196.9% |
| 32 | TWO SIGMA INVESTMENTS#32 · 121,004 sh | 121,004 | $1.3M | <0.01% | +646.8% |
| 33 | HSBC PLC#33 · 122,834 sh | 122,834 | $1.3M | <0.01% | 0.0% |
| 34 | Quadrature Capital Ltd#34 · 118,129 sh | 118,129 | $1.3M | 0.01% | New |
| 35 | Squarepoint Ops#35 · 115,918 sh | 115,918 | $1.3M | <0.01% | +29.6% |
| 36 | XTX Topco Ltd#36 · 107,579 sh | 107,579 | $1.2M | 0.02% | +1.5% |
| 37 | M28 Capital Management#37 · 101,203 sh | 101,203 | $1.1M | 2.36% | 0.0% |
| 38 | MARSHALL WACE, LLP#38 · 72,039 sh | 72,039 | $791.0K | <0.01% | -57.5% |
| 39 | Birchview Capital#39 · 71,218 sh | 71,218 | $782.0K | 0.37% | New |
| 40 | Seven Fleet Capital Management#40 · 60,107 sh | 60,107 | $660.0K | 0.11% | -61.7% |
| 41 | HRT FINANCIAL#41 · 30,748 sh | 30,748 | $337.0K | <0.01% | +156.4% |
| 42 | GEODE CAPITAL MANAGEMENT#42 · 29,538 sh | 29,538 | $324.3K | 0.00% | 0.0% |
| 43 | Virtu Financial#43 · 25,641 sh | 25,641 | $282.0K | <0.01% | New |
| 44 | BANK OF AMERICA#44 · 25,280 sh | 25,280 | $277.6K | 0.00% | -15.1% |
| 45 | Trexquant Investment#45 · 23,842 sh | 23,842 | $261.8K | <0.01% | New |
| 46 | Verdad Advisers#46 · 20,400 sh | 20,400 | $224.0K | 0.21% | New |
| 47 | Scientech Research#47 · 19,133 sh | 19,133 | $210.1K | 0.17% | New |
| 48 | RENAISSANCE TECHNOLOGIES#48 · 16,930 sh | 16,930 | $185.9K | <0.01% | New |
| 49 | Arrowpoint Investment Partners (Singapore) Pte. Ltd.#49 · 16,334 sh | 16,334 | $179.3K | 0.04% | New |
| 50 | Persistent Asset Partners Ltd#50 · 15,170 sh | 15,170 | $166.6K | 0.05% | New |
| 51 | RAYMOND JAMES FINANCIAL#51 · 15,000 sh | 15,000 | $164.7K | 0.00% | -40.0% |
| 52 | RHUMBLINE ADVISERS#52 · 13,815 sh | 13,815 | $151.7K | <0.01% | -0.9% |
| 53 | CITIGROUP#53 · 13,217 sh | 13,217 | $145.1K | 0.00% | +620.3% |
| 54 | AXQ CAPITAL#54 · 12,566 sh | 12,566 | $138.0K | 0.01% | New |
| 55 | SG Americas Securities#55 · 12,056 sh | 12,056 | $132.0K | <0.01% | -95.8% |
| 56 | ACADIAN ASSET MANAGEMENT#56 · 11,836 sh | 11,836 | $129.0K | <0.01% | +145.7% |
| 57 | GAMMA Investing#57 · 11,063 sh | 11,063 | $121.5K | — | +18.1% |
| 58 | CenterBook Partners#58 · 10,416 sh | 10,416 | $114.4K | <0.01% | New |
| 59 | China Universal Asset Management , Ltd.#59 · 7,475 sh | 7,475 | $82.1K | <0.01% | -10.3% |
| 60 | JPMORGAN CHASE#60 · 3,863 sh | 3,863 | $41.7K | 0.00% | -49.4% |
| 61 | BARCLAYS PLC#61 · 3,418 sh | 3,418 | $37.5K | 0.00% | +16.4% |
| 62 | JONES FINANCIAL COMPANIES LLLP#62 · 2,500 sh | 2,500 | $25.4K | 0.00% | 0.0% |
| 63 | Mirae Asset Global Investments , Ltd.#63 · 2,101 sh | 2,101 | $23.1K | 0.00% | -14.2% |
| 64 | Tower Research Capital (TRC)#64 · 1,639 sh | 1,639 | $18.0K | <0.01% | -29.1% |
| 65 | Parallel Advisors#65 · 1,300 sh | 1,300 | $14.3K | <0.01% | 0.0% |
| 66 | Rialto Wealth Management#66 · 1,021 sh | 1,021 | $11.2K | <0.01% | New |
| 67 | GF FUND MANAGEMENT LTD.#67 · 975 sh | 975 | $10.7K | — | -6.9% |
| 68 | Steward Partners Investment Advisory#68 · 100 sh | 100 | $1.1K | 0.00% | 0.0% |
| 69 | Rockefeller Capital Management L.P.#69 · 45 sh | 45 | $494.00 | 0.00% | 0.0% |
| 70 | Caitong International Asset Management , Ltd#70 · 41 sh | 41 | $450.00 | <0.01% | +1266.7% |
| 71 | SBI Securities , Ltd.#71 · 28 sh | 28 | $307.00 | — | 0.0% |
| 72 | ROYAL BANK OF CANADA#72 · 26 sh | 26 | $0.00 | 0.00% | +62.5% |
Funds that sold out of SLN in Q2 2026 (4)
Held SLN at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| Jones Hill Capital301,604 sh | 301,604 | $1.6M |
| Point72 Asset Management, L.P.119,711 sh | 119,711 | $630.9K |
| Dynamic Technology Lab Private Ltd10,490 sh | 10,490 | $55.3K |
| SIMPLEX TRADING612 sh | 612 | $3.2K |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.