Prelude Therapeutics Inc (PRLD) — Institutional Holders, Q2 2026
75 institutional investment managers reported a PRLD position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $264.3M. Every filer is listed below, ranked by position value. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
PRLD in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- RA CAPITAL MANAGEMENT, L.P.New · +6,475,882 sh+$34.5M
- Soleus Capital Management, L.P.New · +3,378,378 sh+$18.0M
- ORBIMED ADVISORSAdded · +2,815,315 sh+$15.0M
- BlackRockAdded · +1,475,615 sh+$7.9M
- Kynam Capital ManagementAdded · +822,536 sh+$4.4M
Biggest sellers
- EcoR1 CapitalSold out · -947,049 sh-$5.0M
- SUSQUEHANNA INTERNATIONAL GROUP, LLPSold out · -267,788 sh-$1.4M
- JANE STREET GROUPSold out · -192,963 sh-$1.0M
- MARSHALL WACE, LLPTrimmed · -168,214 sh-$896.6K
- GOLDMAN SACHS GROUPTrimmed · -115,635 sh-$616.3K
PRLD 13F holders ranked 1–75 of 75
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS#1 · 13,724,571 sh | 13,724,571 | $73.2M | 1.36% | +25.8% |
| 2 | BAKER BROS. ADVISORS#2 · 10,123,824 sh | 10,123,824 | $54.0M | 0.27% | 0.0% |
| 3 | RA CAPITAL MANAGEMENT, L.P.#3 · 6,475,882 sh | 6,475,882 | $34.5M | 0.30% | New |
| 4 | Soleus Capital Management, L.P.#4 · 3,378,378 sh | 3,378,378 | $18.0M | 0.62% | New |
| 5 | Kynam Capital Management#5 · 2,415,087 sh | 2,415,087 | $12.9M | 0.71% | +51.6% |
| 6 | VANGUARD CAPITAL MANAGEMENT#6 · 2,009,445 sh | 2,009,445 | $10.7M | <0.01% | +63.3% |
| 7 | BlackRock#7 · 1,797,501 sh | 1,797,501 | $9.6M | <0.01% | +458.4% |
| 8 | SPHERA FUNDS MANAGEMENT LTD.#8 · 1,019,832 sh | 1,019,832 | $5.4M | 0.71% | +82.7% |
| 9 | TWO SIGMA INVESTMENTS#9 · 993,369 sh | 993,369 | $5.3M | <0.01% | +7.6% |
| 10 | ADAR1 Capital Management#10 · 900,900 sh | 900,900 | $4.8M | 0.22% | +489.5% |
| 11 | MILLENNIUM MANAGEMENT#11 · 844,993 sh | 844,993 | $4.5M | <0.01% | +120.8% |
| 12 | GEODE CAPITAL MANAGEMENT#12 · 841,862 sh | 841,862 | $4.5M | <0.01% | +178.3% |
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C.#13 · 766,095 sh | 766,095 | $4.1M | <0.01% | New |
| 14 | ACADIAN ASSET MANAGEMENT#14 · 611,359 sh | 611,359 | $3.3M | <0.01% | +19.5% |
| 15 | MORGAN STANLEY#15 · 503,860 sh | 503,860 | $2.7M | <0.01% | +56.4% |
| 16 | STATE STREET#16 · 428,787 sh | 428,787 | $2.3M | <0.01% | +210.2% |
| 17 | UBS Group AG#17 · 318,797 sh | 318,797 | $1.7M | <0.01% | +394.2% |
| 18 | VANGUARD FIDUCIARY#18 · 284,886 sh | 284,886 | $1.5M | <0.01% | +81.0% |
| 19 | RENAISSANCE TECHNOLOGIES#19 · 281,200 sh | 281,200 | $1.5M | <0.01% | +2.2% |
| 20 | NORTHERN#20 · 240,599 sh | 240,599 | $1.3M | <0.01% | +380.0% |
| 21 | VANGUARD PORTFOLIO MANAGEMENT#21 · 193,920 sh | 193,920 | $1.0M | 0.00% | New |
| 22 | MARSHALL WACE, LLP#22 · 190,692 sh | 190,692 | $1.0M | <0.01% | -46.9% |
| 23 | Connor, Clark & Lunn Investment Management Ltd.#23 · 125,606 sh | 125,606 | $669.5K | <0.01% | +15.1% |
| 24 | GOLDMAN SACHS GROUP#24 · 120,834 sh | 120,834 | $644.0K | <0.01% | -48.9% |
| 25 | Hillsdale Investment Management#25 · 81,400 sh | 81,400 | $433.9K | <0.01% | New |
| 26 | Bank of New York Mellon#26 · 68,187 sh | 68,187 | $363.4K | <0.01% | New |
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT#27 · 67,622 sh | 67,622 | $360.4K | 0.00% | New |
| 28 | BRIDGEWAY CAPITAL MANAGEMENT#28 · 64,500 sh | 64,500 | $343.8K | <0.01% | +20.6% |
| 29 | Squarepoint Ops#29 · 59,540 sh | 59,540 | $317.3K | <0.01% | New |
| 30 | PANAGORA ASSET MANAGEMENT#30 · 47,574 sh | 47,574 | $253.6K | <0.01% | New |
| 31 | Mariner#31 · 45,261 sh | 45,261 | $241.2K | <0.01% | New |
| 32 | Nuveen#32 · 37,023 sh | 37,023 | $197.3K | 0.00% | New |
| 33 | DIMENSIONAL FUND ADVISORS#33 · 35,210 sh | 35,210 | $186.8K | 0.00% | 0.0% |
| 34 | Invesco Ltd.#34 · 34,742 sh | 34,742 | $185.2K | 0.00% | New |
| 35 | Cerity Partners#35 · 32,875 sh | 32,875 | $175.2K | <0.01% | 0.0% |
| 36 | State of Wyoming#36 · 32,862 sh | 32,862 | $175.2K | 0.02% | New |
| 37 | Graham Capital Management, L.P.#37 · 29,770 sh | 29,770 | $158.7K | <0.01% | +162.5% |
| 38 | DEUTSCHE BANK AG\#38 · 27,824 sh | 27,824 | $148.3K | 0.00% | New |
| 39 | WELLS FARGO & COMPANY#39 · 25,325 sh | 25,325 | $135.0K | 0.00% | New |
| 40 | BANK OF AMERICA#40 · 23,875 sh | 23,875 | $127.3K | 0.00% | -57.8% |
| 41 | PRICE T ROWE ASSOCIATES#41 · 22,758 sh | 22,758 | $122.0K | 0.00% | New |
| 42 | CITADEL ADVISORS#42 · 22,554 sh | 22,554 | $120.2K | 0.00% | -81.9% |
| 43 | RHUMBLINE ADVISERS#43 · 22,074 sh | 22,074 | $117.6K | <0.01% | New |
| 44 | Vanguard Global Advisers#44 · 16,210 sh | 16,210 | $86.4K | 0.00% | +249.7% |
| 45 | ExodusPoint Capital Management#45 · 15,475 sh | 15,475 | $82.5K | <0.01% | New |
| 46 | BARCLAYS PLC#46 · 14,529 sh | 14,529 | $77.4K | 0.00% | +68.9% |
| 47 | NEW YORK STATE COMMON RETIREMENT FUND#47 · 14,200 sh | 14,200 | $75.7K | <0.01% | New |
| 48 | HSBC PLC#48 · 13,652 sh | 13,652 | $74.4K | 0.00% | 0.0% |
| 49 | MANGROVE PARTNERS IM#49 · 13,352 sh | 13,352 | $71.2K | <0.01% | New |
| 50 | Qube Research & Technologies Ltd#50 · 13,110 sh | 13,110 | $69.9K | <0.01% | -20.1% |
| 51 | CITIGROUP#51 · 13,033 sh | 13,033 | $69.5K | 0.00% | New |
| 52 | MIRAE ASSET GLOBAL ETFS Ltd.#52 · 12,784 sh | 12,784 | $68.1K | <0.01% | New |
| 53 | GSA CAPITAL PARTNERS LLP#53 · 12,672 sh | 12,672 | $68.0K | <0.01% | New |
| 54 | JPMORGAN CHASE#54 · 13,538 sh | 13,538 | $66.7K | 0.00% | New |
| 55 | Spark Investment Management#55 · 10,600 sh | 10,600 | $56.5K | 0.11% | New |
| 56 | Police & Firemen's Retirement System of New Jersey#56 · 10,492 sh | 10,492 | $55.9K | <0.01% | New |
| 57 | ALLIANCEBERNSTEIN L.P.#57 · 10,530 sh | 10,530 | $36.0K | 0.00% | New |
| 58 | LOS ANGELES CAPITAL MANAGEMENT#58 · 6,430 sh | 6,430 | $34.3K | <0.01% | New |
| 59 | FMR#59 · 5,629 sh | 5,629 | $30.0K | 0.00% | -6.3% |
| 60 | STRS OHIO#60 · 5,500 sh | 5,500 | $29.3K | <0.01% | New |
| 61 | BNP PARIBAS FINANCIAL MARKETS#61 · 4,104 sh | 4,104 | $21.9K | 0.00% | +4220.0% |
| 62 | GROUP ONE TRADING, L.P.#62 · 3,907 sh | 3,907 | $20.8K | 0.00% | 0.0% |
| 63 | Legal & General Group Plc#63 · 2,699 sh | 2,699 | $14.4K | 0.00% | New |
| 64 | ROYAL BANK OF CANADA#64 · 2,658 sh | 2,658 | $14.0K | 0.00% | +14.0% |
| 65 | Ameritas Investment Partners#65 · 2,520 sh | 2,520 | $13.4K | <0.01% | New |
| 66 | Tower Research Capital (TRC)#66 · 2,377 sh | 2,377 | $12.7K | <0.01% | New |
| 67 | Russell Investments Group, Ltd.#67 · 2,220 sh | 2,220 | $11.8K | 0.00% | New |
| 68 | NISA INVESTMENT ADVISORS#68 · 1,634 sh | 1,634 | $8.7K | — | 0.0% |
| 69 | PNC FINANCIAL SERVICES GROUP#69 · 1,171 sh | 1,171 | $6.2K | 0.00% | 0.0% |
| 70 | Quarry#70 · 755 sh | 755 | $4.0K | <0.01% | New |
| 71 | Fortitude Family Office#71 · 230 sh | 230 | $1.2K | — | 0.0% |
| 72 | Sterling Capital Management#72 · 97 sh | 97 | $517.00 | — | New |
| 73 | SBI Securities , Ltd.#73 · 22 sh | 22 | $117.00 | — | -99.2% |
| 74 | Caitong International Asset Management , Ltd#74 · 18 sh | 18 | $96.00 | 0.00% | New |
| 75 | Optiver Holding B.V.#75 · 4 sh | 4 | $21.00 | 0.00% | -80.0% |
Funds that sold out of PRLD in Q2 2026 (13)
Held PRLD at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| EcoR1 Capital947,049 sh | 947,049 | $3.2M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP267,788 sh | 267,788 | $915.8K |
| JANE STREET GROUP192,963 sh | 192,963 | $659.9K |
| HRT FINANCIAL58,699 sh | 58,699 | $200.0K |
| XTX Topco Ltd57,190 sh | 57,190 | $195.6K |
| Focus Partners Wealth50,007 sh | 50,007 | $171.0K |
| OMERS ADMINISTRATION32,700 sh | 32,700 | $111.8K |
| PRUDENTIAL FINANCIAL17,420 sh | 17,420 | $59.6K |
| Point72 Asset Management, L.P.16,329 sh | 16,329 | $55.8K |
| Diametric Capital11,980 sh | 11,980 | $41.0K |
| NINE MASTS CAPITAL Ltd11,699 sh | 11,699 | $40.0K |
| AMERICAN CENTURY COMPANIES10,294 sh | 10,294 | $35.2K |
| CALDWELL SUTTER CAPITAL1,000 sh | 1,000 | $3.4K |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.