PUMA BIOTECHNOLOGY, INC. (PBYI) — Institutional Holders, Q2 2026
161 institutional investment managers reported a PBYI position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $313.6M. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
PBYI in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- LSV ASSET MANAGEMENTAdded · +435,113 sh+$3.5M
- AMERICAN CENTURY COMPANIESAdded · +403,650 sh+$3.3M
- GEODE CAPITAL MANAGEMENTAdded · +322,063 sh+$2.6M
- Invesco Ltd.Added · +205,958 sh+$1.7M
- BlackRockAdded · +205,784 sh+$1.7M
Biggest sellers
- MILLENNIUM MANAGEMENTTrimmed · -875,279 sh-$7.1M
- Connor, Clark & Lunn Investment Management Ltd.Trimmed · -139,852 sh-$1.1M
- RENAISSANCE TECHNOLOGIESTrimmed · -106,200 sh-$861.3K
- MORGAN STANLEYTrimmed · -94,072 sh-$762.9K
- SEI INVESTMENTSTrimmed · -89,513 sh-$726.0K
PBYI 13F holders ranked 1–100 of 161
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | ACORN CAPITAL ADVISORS#1 · 4,131,299 sh | 4,131,299 | $33.5M | 9.14% | 0.0% |
| 2 | BlackRock#2 · 3,804,736 sh | 3,804,736 | $30.9M | <0.01% | +5.7% |
| 3 | AMERICAN CENTURY COMPANIES#3 · 2,319,996 sh | 2,319,996 | $18.8M | <0.01% | +21.1% |
| 4 | ACADIAN ASSET MANAGEMENT#4 · 2,053,523 sh | 2,053,523 | $16.6M | 0.02% | +0.6% |
| 5 | RENAISSANCE TECHNOLOGIES#5 · 1,836,213 sh | 1,836,213 | $14.9M | 0.02% | -5.5% |
| 6 | VANGUARD CAPITAL MANAGEMENT#6 · 1,835,643 sh | 1,835,643 | $14.9M | <0.01% | +1.0% |
| 7 | VANGUARD PORTFOLIO MANAGEMENT#7 · 1,825,599 sh | 1,825,599 | $14.8M | <0.01% | +5.2% |
| 8 | LSV ASSET MANAGEMENT#8 · 1,617,981 sh | 1,617,981 | $13.1M | 0.02% | +36.8% |
| 9 | DIMENSIONAL FUND ADVISORS#9 · 1,518,014 sh | 1,518,014 | $12.3M | <0.01% | +5.7% |
| 10 | GEODE CAPITAL MANAGEMENT#10 · 1,339,405 sh | 1,339,405 | $10.9M | <0.01% | +31.7% |
| 11 | O'SHAUGHNESSY ASSET MANAGEMENT#11 · 1,123,783 sh | 1,123,783 | $9.1M | 0.04% | -1.3% |
| 12 | STATE STREET#12 · 952,165 sh | 952,165 | $7.7M | <0.01% | +3.8% |
| 13 | KENNEDY CAPITAL MANAGEMENT#13 · 873,253 sh | 873,253 | $7.1M | 0.13% | -1.8% |
| 14 | BRIDGEWAY CAPITAL MANAGEMENT#14 · 791,616 sh | 791,616 | $6.4M | 0.11% | +2.1% |
| 15 | RITHOLTZ WEALTH MANAGEMENT#15 · 749,798 sh | 749,798 | $6.1M | 0.09% | -3.2% |
| 16 | AQR CAPITAL MANAGEMENT#16 · 725,192 sh | 725,192 | $5.9M | <0.01% | -9.4% |
| 17 | GOLDMAN SACHS GROUP#17 · 669,156 sh | 669,156 | $5.4M | <0.01% | -0.1% |
| 18 | NORTHERN#18 · 652,386 sh | 652,386 | $5.3M | <0.01% | +1.7% |
| 19 | Connor, Clark & Lunn Investment Management Ltd.#19 · 642,946 sh | 642,946 | $5.2M | <0.01% | -17.9% |
| 20 | UBS Group AG#20 · 636,761 sh | 636,761 | $5.2M | <0.01% | +19.2% |
| 21 | MILLENNIUM MANAGEMENT#21 · 602,240 sh | 602,240 | $4.9M | <0.01% | -59.2% |
| 22 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP#22 · 532,450 sh | 532,450 | $4.3M | <0.01% | -1.1% |
| 23 | SEI INVESTMENTS#23 · 418,669 sh | 418,669 | $3.4M | <0.01% | -17.6% |
| 24 | GLOBEFLEX CAPITAL L P#24 · 382,807 sh | 382,807 | $3.1M | 0.40% | +9.5% |
| 25 | Bank of New York Mellon#25 · 360,734 sh | 360,734 | $2.9M | <0.01% | +3.7% |
| 26 | D. E. Shaw#26 · 316,343 sh | 316,343 | $2.6M | <0.01% | -9.9% |
| 27 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM#27 · 309,106 sh | 309,106 | $2.5M | <0.01% | +13.3% |
| 28 | Invesco Ltd.#28 · 301,002 sh | 301,002 | $2.4M | <0.01% | +216.7% |
| 29 | Russell Investments Group, Ltd.#29 · 272,234 sh | 272,234 | $2.2M | <0.01% | +8.2% |
| 30 | VANGUARD FIDUCIARY#30 · 269,070 sh | 269,070 | $2.2M | <0.01% | +6.9% |
| 31 | MORGAN STANLEY#31 · 265,670 sh | 265,670 | $2.2M | <0.01% | -26.1% |
| 32 | FEDERATED HERMES#32 · 250,766 sh | 250,766 | $2.0M | <0.01% | +5.5% |
| 33 | Empowered Funds#33 · 220,316 sh | 220,316 | $1.8M | <0.01% | +8.0% |
| 34 | PANAGORA ASSET MANAGEMENT#34 · 217,545 sh | 217,545 | $1.8M | <0.01% | +11.6% |
| 35 | PRUDENTIAL FINANCIAL#35 · 213,599 sh | 213,599 | $1.7M | <0.01% | -15.6% |
| 36 | JPMORGAN CHASE#36 · 211,339 sh | 211,339 | $1.7M | <0.01% | -4.3% |
| 37 | FMR#37 · 211,444 sh | 211,444 | $1.7M | <0.01% | +10.2% |
| 38 | STATE OF WISCONSIN INVESTMENT BOARD#38 · 188,232 sh | 188,232 | $1.5M | <0.01% | -9.8% |
| 39 | FRANKLIN RESOURCES#39 · 172,010 sh | 172,010 | $1.4M | <0.01% | -20.1% |
| 40 | Prospera Financial Services#40 · 158,762 sh | 158,762 | $1.3M | 0.02% | -8.3% |
| 41 | Haven Private#41 · 148,448 sh | 148,448 | $1.2M | 0.46% | -4.4% |
| 42 | TWO SIGMA INVESTMENTS#42 · 140,587 sh | 140,587 | $1.1M | <0.01% | +981.4% |
| 43 | FIRST ADVISORS#43 · 130,206 sh | 130,206 | $1.1M | <0.01% | +5.4% |
| 44 | Round Rock Advisors#44 · 128,912 sh | 128,912 | $1.0M | 0.13% | 0.0% |
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT#45 · 128,243 sh | 128,243 | $1.0M | <0.01% | +10.6% |
| 46 | WELLINGTON MANAGEMENT GROUP LLP#46 · 126,091 sh | 126,091 | $1.0M | <0.01% | New |
| 47 | STRS OHIO#47 · 84,600 sh | 84,600 | $686.1K | <0.01% | -7.5% |
| 48 | Nuveen#48 · 82,298 sh | 82,298 | $667.4K | <0.01% | +4.0% |
| 49 | EVERGREEN CAPITAL MANAGEMENT#49 · 73,731 sh | 73,731 | $598.0K | — | -23.2% |
| 50 | CANADA PENSION PLAN INVESTMENT BOARD#50 · 73,500 sh | 73,500 | $596.1K | <0.01% | +222.4% |
| 51 | Trexquant Investment#51 · 72,223 sh | 72,223 | $585.7K | <0.01% | New |
| 52 | Vise Technologies#52 · 72,030 sh | 72,030 | $584.2K | <0.01% | +78.7% |
| 53 | NOMURA ASSET MANAGEMENT INTERNATIONAL#53 · 61,255 sh | 61,255 | $497.0K | <0.01% | 0.0% |
| 54 | OpenArc Corporate Advisory#54 · 59,491 sh | 59,491 | $482.5K | — | -33.5% |
| 55 | RHUMBLINE ADVISERS#55 · 57,510 sh | 57,510 | $466.4K | <0.01% | +8.4% |
| 56 | D'Orazio & Associates#56 · 48,680 sh | 48,680 | $394.8K | 0.05% | -2.5% |
| 57 | Vanguard Global Advisers#57 · 46,267 sh | 46,267 | $375.2K | <0.01% | +58.6% |
| 58 | DEUTSCHE BANK AG\#58 · 43,192 sh | 43,192 | $350.3K | <0.01% | +30.3% |
| 59 | Man Group plc#59 · 41,506 sh | 41,506 | $336.6K | <0.01% | -12.4% |
| 60 | WINTON GROUP Ltd#60 · 40,509 sh | 40,509 | $328.5K | 0.01% | -38.9% |
| 61 | XTX Topco Ltd#61 · 40,296 sh | 40,296 | $326.8K | <0.01% | +166.6% |
| 62 | State of Wyoming#62 · 39,833 sh | 39,833 | $323.0K | 0.03% | -47.5% |
| 63 | WELLS FARGO & COMPANY#63 · 37,606 sh | 37,606 | $305.0K | 0.00% | +131.1% |
| 64 | EntryPoint Capital#64 · 37,386 sh | 37,386 | $303.2K | 0.07% | -30.1% |
| 65 | PRICE T ROWE ASSOCIATES#65 · 36,343 sh | 36,343 | $295.0K | 0.00% | +16.1% |
| 66 | Baron Wealth Management#66 · 36,372 sh | 36,372 | $295.0K | 0.08% | -5.0% |
| 67 | Creative Planning#67 · 35,737 sh | 35,737 | $289.8K | <0.01% | +54.6% |
| 68 | LPL Financial#68 · 34,537 sh | 34,537 | $280.1K | <0.01% | -5.7% |
| 69 | Universal- Beteiligungs- und Servicegesellschaft mbH#69 · 34,485 sh | 34,485 | $279.7K | <0.01% | -12.3% |
| 70 | BANK OF AMERICA#70 · 31,747 sh | 31,747 | $257.5K | 0.00% | -21.3% |
| 71 | Kathmere Capital Management#71 · 31,172 sh | 31,172 | $252.8K | — | +4.7% |
| 72 | ENVESTNET ASSET MANAGEMENT#72 · 29,190 sh | 29,190 | $236.7K | <0.01% | +9.9% |
| 73 | Y-Intercept (Hong Kong) Ltd#73 · 26,222 sh | 26,222 | $212.7K | — | New |
| 74 | MARTINGALE ASSET MANAGEMENT L P#74 · 25,364 sh | 25,364 | $205.7K | <0.01% | New |
| 75 | Metis Global Partners#75 · 25,264 sh | 25,264 | $204.9K | <0.01% | 0.0% |
| 76 | MetLife Investment Management#76 · 24,873 sh | 24,873 | $201.7K | <0.01% | +57.0% |
| 77 | C2C Wealth Management#77 · 23,620 sh | 23,620 | $191.6K | — | 0.0% |
| 78 | CITIGROUP#78 · 21,666 sh | 21,666 | $175.7K | <0.01% | +533.1% |
| 79 | PRELUDE CAPITAL MANAGEMENT#79 · 21,548 sh | 21,548 | $174.8K | 0.01% | +16.8% |
| 80 | One Wealth Advisors#80 · 21,079 sh | 21,079 | $171.0K | 0.02% | 0.0% |
| 81 | MIRAE ASSET GLOBAL ETFS Ltd.#81 · 20,383 sh | 20,383 | $165.3K | <0.01% | -1.2% |
| 82 | BAILARD#82 · 18,100 sh | 18,100 | $146.8K | — | 0.0% |
| 83 | Allspring Global Investments#83 · 17,945 sh | 17,945 | $143.4K | <0.01% | +5.2% |
| 84 | Spark Investment Management#84 · 17,000 sh | 17,000 | $137.9K | 0.27% | New |
| 85 | ALLIANCEBERNSTEIN L.P.#85 · 21,360 sh | 21,360 | $136.5K | 0.00% | +54.8% |
| 86 | Police & Firemen's Retirement System of New Jersey#86 · 15,719 sh | 15,719 | $127.5K | <0.01% | 0.0% |
| 87 | SUSQUEHANNA INTERNATIONAL GROUP, LLP#87 · 15,476 sh | 15,476 | $125.5K | 0.00% | -3.8% |
| 88 | Lido Advisors#88 · 15,045 sh | 15,045 | $122.0K | <0.01% | New |
| 89 | Mariner#89 · 14,869 sh | 14,869 | $120.6K | <0.01% | +1.5% |
| 90 | Caprock Group#90 · 13,862 sh | 13,862 | $112.4K | <0.01% | -46.7% |
| 91 | PERKINS CAPITAL MANAGEMENT#91 · 13,400 sh | 13,400 | $108.7K | 0.08% | +7.2% |
| 92 | TOCQUEVILLE ASSET MANAGEMENT L.P.#92 · 13,312 sh | 13,312 | $108.0K | <0.01% | +2.7% |
| 93 | WEALTH ENHANCEMENT ADVISORY SERVICES#93 · 13,203 sh | 13,203 | $105.6K | — | +13.5% |
| 94 | OSAIC#94 · 12,169 sh | 12,169 | $98.7K | <0.01% | +4.3% |
| 95 | MANUFACTURERS LIFE INSURANCE COMPANY, THE#95 · 12,056 sh | 12,056 | $97.8K | <0.01% | +2.5% |
| 96 | R Squared Ltd#96 · 11,991 sh | 11,991 | $97.2K | 0.05% | New |
| 97 | Abel Hall#97 · 11,520 sh | 11,520 | $93.4K | — | +0.4% |
| 98 | BARCLAYS PLC#98 · 11,202 sh | 11,202 | $90.8K | 0.00% | -19.9% |
| 99 | IEQ CAPITAL#99 · 10,671 sh | 10,671 | $86.5K | <0.01% | -28.4% |
| 100 | Cerity Partners#100 · 10,512 sh | 10,512 | $85.3K | <0.01% | -19.2% |
Funds that sold out of PBYI in Q2 2026 (15)
Held PBYI at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| CITADEL ADVISORS29,959 sh | 29,959 | $191.4K |
| VIRTUS ADVISERS29,347 sh | 29,347 | $187.5K |
| Engineers Gate Manager28,600 sh | 28,600 | $182.8K |
| LAZARD ASSET MANAGEMENT17,970 sh | 17,970 | $114.8K |
| Quadrature Capital Ltd16,745 sh | 16,745 | $107.0K |
| Ashton Thomas Private Wealth13,500 sh | 13,500 | $86.3K |
| HRT FINANCIAL13,073 sh | 13,073 | $83.0K |
| Cambridge Investment Research Advisors12,563 sh | 12,563 | $80.0K |
| Abacus Wealth Partners11,199 sh | 11,199 | $71.6K |
| Stokes Family Office10,092 sh | 10,092 | $64.5K |
| MAI Capital Management7,558 sh | 7,558 | $48.3K |
| Intentional Wealth Strategies1,128 sh | 1,128 | $7.2K |
| Root Financial Partners269 sh | 269 | $1.7K |
| Frazier Financial Advisors183 sh | 183 | $1.2K |
| Wealth Preservation Advisors1 sh | 1 | $6.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.