Orchestra BioMed Holdings, Inc. (OBIO) — Institutional Holders, Q2 2026
77 institutional investment managers reported a OBIO position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $119.4M. Every filer is listed below, ranked by position value. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
OBIO in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- BlackRockAdded · +1,874,673 sh+$8.1M
- RTW INVESTMENTSAdded · +1,250,000 sh+$5.4M
- UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMENew · +642,154 sh+$2.8M
- GEODE CAPITAL MANAGEMENTAdded · +522,416 sh+$2.3M
- RICE HALL JAMES & ASSOCIATESAdded · +404,999 sh+$1.7M
Biggest sellers
- MILLENNIUM MANAGEMENTSold out · -702,543 sh-$3.0M
- Affinity Asset AdvisorsTrimmed · -369,150 sh-$1.6M
- MARSHALL WACE, LLPSold out · -188,484 sh-$813.3K
- 683 Capital ManagementSold out · -185,000 sh-$798.3K
- VANGUARD CAPITAL MANAGEMENTTrimmed · -181,403 sh-$782.8K
OBIO 13F holders ranked 1–77 of 77
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | RTW INVESTMENTS#1 · 9,556,063 sh | 9,556,063 | $41.2M | 0.35% | +15.0% |
| 2 | PERCEPTIVE ADVISORS#2 · 5,037,906 sh | 5,037,906 | $21.7M | 0.33% | 0.0% |
| 3 | BlackRock#3 · 2,510,387 sh | 2,510,387 | $10.8M | <0.01% | +294.9% |
| 4 | VANGUARD CAPITAL MANAGEMENT#4 · 2,022,916 sh | 2,022,916 | $8.7M | <0.01% | -8.2% |
| 5 | GEODE CAPITAL MANAGEMENT#5 · 1,007,908 sh | 1,007,908 | $4.4M | <0.01% | +107.6% |
| 6 | Alyeska Investment Group, L.P.#6 · 1,000,000 sh | 1,000,000 | $4.3M | 0.01% | 0.0% |
| 7 | Propel Bio Management#7 · 896,701 sh | 896,701 | $3.9M | 2.02% | 0.0% |
| 8 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#8 · 642,154 sh | 642,154 | $2.8M | <0.01% | New |
| 9 | STATE STREET#9 · 516,050 sh | 516,050 | $2.2M | <0.01% | +204.6% |
| 10 | RICE HALL JAMES & ASSOCIATES#10 · 424,000 sh | 424,000 | $1.8M | 0.09% | +2131.5% |
| 11 | CHARLES SCHWAB INVESTMENT MANAGEMENT#11 · 349,544 sh | 349,544 | $1.5M | <0.01% | +31.7% |
| 12 | NORTHERN#12 · 343,640 sh | 343,640 | $1.5M | <0.01% | +190.5% |
| 13 | UBS Group AG#13 · 325,773 sh | 325,773 | $1.4M | <0.01% | +547.5% |
| 14 | VANGUARD FIDUCIARY#14 · 292,253 sh | 292,253 | $1.3M | <0.01% | +24.2% |
| 15 | VANGUARD PORTFOLIO MANAGEMENT#15 · 274,973 sh | 274,973 | $1.2M | <0.01% | New |
| 16 | Knott David M Jr#16 · 253,651 sh | 253,651 | $1.1M | 0.58% | 0.0% |
| 17 | Flat Footed#17 · 251,372 sh | 251,372 | $1.1M | 0.08% | New |
| 18 | Simplify Asset Management#18 · 219,387 sh | 219,387 | $946.7K | 0.01% | 0.0% |
| 19 | GOLDMAN SACHS GROUP#19 · 179,606 sh | 179,606 | $775.0K | <0.01% | +15.7% |
| 20 | DAFNA Capital Management#20 · 126,841 sh | 126,841 | $547.3K | 0.10% | 0.0% |
| 21 | RENAISSANCE TECHNOLOGIES#21 · 90,000 sh | 90,000 | $388.4K | <0.01% | +26.9% |
| 22 | IFP Advisors#22 · 89,608 sh | 89,608 | $386.7K | — | -9.4% |
| 23 | Daytona Street Capital#23 · 96,398 sh | 96,398 | $379.3K | — | +83.3% |
| 24 | Bank of New York Mellon#24 · 86,103 sh | 86,103 | $371.5K | <0.01% | New |
| 25 | BRIDGEWAY CAPITAL MANAGEMENT#25 · 80,600 sh | 80,600 | $347.8K | <0.01% | +14.2% |
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP#26 · 65,804 sh | 65,804 | $283.9K | 0.00% | -32.5% |
| 27 | CITADEL ADVISORS#27 · 56,191 sh | 56,191 | $242.5K | 0.00% | -29.0% |
| 28 | Nuveen#28 · 52,118 sh | 52,118 | $224.9K | <0.01% | New |
| 29 | Holos Integrated Wealth#29 · 51,595 sh | 51,595 | $204.3K | — | 0.0% |
| 30 | NewEdge Advisors#30 · 44,083 sh | 44,083 | $190.2K | <0.01% | 0.0% |
| 31 | Y-Intercept (Hong Kong) Ltd#31 · 43,486 sh | 43,486 | $187.6K | — | New |
| 32 | DEUTSCHE BANK AG\#32 · 39,672 sh | 39,672 | $171.4K | 0.00% | New |
| 33 | XTX Topco Ltd#33 · 38,814 sh | 38,814 | $167.5K | <0.01% | New |
| 34 | WELLS FARGO & COMPANY#34 · 36,356 sh | 36,356 | $156.9K | 0.00% | New |
| 35 | HighTower Advisors#35 · 35,375 sh | 35,375 | $152.6K | <0.01% | +93.6% |
| 36 | Affinity Asset Advisors#36 · 33,400 sh | 33,400 | $144.1K | <0.01% | -91.7% |
| 37 | PRICE T ROWE ASSOCIATES#37 · 32,689 sh | 32,689 | $142.0K | 0.00% | New |
| 38 | RHUMBLINE ADVISERS#38 · 31,940 sh | 31,940 | $137.8K | <0.01% | New |
| 39 | MORGAN STANLEY#39 · 29,160 sh | 29,160 | $125.8K | 0.00% | -18.2% |
| 40 | ALGERT GLOBAL#40 · 28,486 sh | 28,486 | $122.9K | <0.01% | +94.4% |
| 41 | Meramec Financial Planners#41 · 30,000 sh | 30,000 | $114.6K | 0.04% | 0.0% |
| 42 | AXQ CAPITAL#42 · 25,448 sh | 25,448 | $109.8K | 0.01% | New |
| 43 | Invesco Ltd.#43 · 24,689 sh | 24,689 | $106.5K | 0.00% | New |
| 44 | MetLife Investment Management#44 · 23,994 sh | 23,994 | $103.5K | <0.01% | New |
| 45 | BANK OF AMERICA#45 · 23,822 sh | 23,822 | $102.8K | 0.00% | -54.8% |
| 46 | JPMORGAN CHASE#46 · 20,880 sh | 20,880 | $99.2K | 0.00% | +390.4% |
| 47 | TWO SIGMA INVESTMENTS#47 · 22,563 sh | 22,563 | $97.4K | <0.01% | -62.5% |
| 48 | CANADA PENSION PLAN INVESTMENT BOARD#48 · 21,100 sh | 21,100 | $91.0K | <0.01% | +86.7% |
| 49 | NEW YORK STATE COMMON RETIREMENT FUND#49 · 20,400 sh | 20,400 | $88.0K | <0.01% | New |
| 50 | CITIGROUP#50 · 20,165 sh | 20,165 | $87.0K | 0.00% | -21.0% |
| 51 | MIRAE ASSET GLOBAL ETFS Ltd.#51 · 18,352 sh | 18,352 | $79.2K | <0.01% | New |
| 52 | JANE STREET GROUP#52 · 15,360 sh | 15,360 | $66.3K | 0.00% | -72.4% |
| 53 | Vanguard Global Advisers#53 · 13,948 sh | 13,948 | $60.2K | 0.00% | 0.0% |
| 54 | BARCLAYS PLC#54 · 13,518 sh | 13,518 | $58.3K | 0.00% | -77.2% |
| 55 | ABLE Financial Group#55 · 13,402 sh | 13,402 | $57.8K | — | 0.0% |
| 56 | Sargent Investment Group#56 · 13,120 sh | 13,120 | $56.6K | <0.01% | New |
| 57 | Frec Markets#57 · 13,048 sh | 13,048 | $56.3K | <0.01% | 0.0% |
| 58 | Police & Firemen's Retirement System of New Jersey#58 · 11,755 sh | 11,755 | $50.7K | <0.01% | New |
| 59 | Garden State Investment Advisory Services#59 · 10,562 sh | 10,562 | $45.6K | <0.01% | 0.0% |
| 60 | China Universal Asset Management , Ltd.#60 · 9,530 sh | 9,530 | $41.1K | <0.01% | -4.9% |
| 61 | BNP PARIBAS FINANCIAL MARKETS#61 · 8,214 sh | 8,214 | $35.4K | 0.00% | +464.1% |
| 62 | Legal & General Group Plc#62 · 3,924 sh | 3,924 | $16.9K | 0.00% | New |
| 63 | Ameritas Investment Partners#63 · 3,617 sh | 3,617 | $15.6K | <0.01% | New |
| 64 | Tower Research Capital (TRC)#64 · 3,601 sh | 3,601 | $15.5K | <0.01% | +558.3% |
| 65 | Russell Investments Group, Ltd.#65 · 3,187 sh | 3,187 | $13.8K | 0.00% | New |
| 66 | Mirae Asset Global Investments , Ltd.#66 · 2,678 sh | 2,678 | $11.6K | 0.00% | -9.1% |
| 67 | SIMPLEX TRADING#67 · 2,564 sh | 2,564 | $11.1K | 0.00% | +7.7% |
| 68 | ROYAL BANK OF CANADA#68 · 1,864 sh | 1,864 | $8.0K | 0.00% | +99.1% |
| 69 | AdvisorNet Financial#69 · 1,696 sh | 1,696 | $7.3K | — | 0.0% |
| 70 | GF FUND MANAGEMENT LTD.#70 · 1,173 sh | 1,173 | $5.1K | — | -6.9% |
| 71 | JONES FINANCIAL COMPANIES LLLP#71 · 888 sh | 888 | $3.8K | 0.00% | +128.9% |
| 72 | FMR#72 · 265 sh | 265 | $1.1K | 0.00% | -98.5% |
| 73 | Sterling Capital Management#73 · 140 sh | 140 | $604.00 | — | New |
| 74 | Optiver Holding B.V.#74 · 40 sh | 40 | $173.00 | 0.00% | New |
| 75 | Caitong International Asset Management , Ltd#75 · 15 sh | 15 | $65.00 | 0.00% | New |
| 76 | SBI Securities , Ltd.#76 · 6 sh | 6 | $26.00 | — | 0.0% |
| 77 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM#77 · 549 sh | 549 | — | — | New |
Funds that sold out of OBIO in Q2 2026 (13)
Held OBIO at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| MILLENNIUM MANAGEMENT702,543 sh | 702,543 | $3.0M |
| MARSHALL WACE, LLP188,484 sh | 188,484 | $801.1K |
| 683 Capital Management185,000 sh | 185,000 | $786.3K |
| Qube Research & Technologies Ltd108,953 sh | 108,953 | $463.1K |
| Point72 Asset Management, L.P.87,888 sh | 87,888 | $373.5K |
| Hudson Bay Capital Management71,134 sh | 71,134 | $302.3K |
| Brevan Howard Capital Management36,769 sh | 36,769 | $156.3K |
| Catalyst Funds Management Pty Ltd27,644 sh | 27,644 | $117.5K |
| Cannon Global Investment Management22,607 sh | 22,607 | $96.1K |
| Diametric Capital18,919 sh | 18,919 | $80.4K |
| OMERS ADMINISTRATION16,200 sh | 16,200 | $68.8K |
| PRELUDE CAPITAL MANAGEMENT12,389 sh | 12,389 | $52.7K |
| Schonfeld Strategic Advisors10,953 sh | 10,953 | $46.5K |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.