Krystal Biotech, Inc. (KRYS) — Institutional Holders, Q2 2026

426 institutional investment managers reported a KRYS position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $11.0B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.

← KRYS stock profile

KRYS in Q2 2026: what funds did

Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.

New positions

Added to

176

Trimmed

105

Sold out

Biggest buyers

BlackRockAdded · +240,976 sh+$89.6M
PRICE T ROWE ASSOCIATESAdded · +202,326 sh+$75.2M
WILLIAM BLAIR INVESTMENT MANAGEMENTAdded · +162,975 sh+$60.6M
VANGUARD PORTFOLIO MANAGEMENTAdded · +118,178 sh+$43.9M
WESTFIELD CAPITAL MANAGEMENTNew · +98,707 sh+$36.7M

Biggest sellers

Bellevue Group AGTrimmed · -404,255 sh-$150.2M
Soleus Capital Management, L.P.Trimmed · -213,833 sh-$79.5M
MARSHALL WACE, LLPSold out · -68,343 sh-$25.4M
BRAIDWELLTrimmed · -53,450 sh-$19.9M
Capital World InvestorsTrimmed · -46,877 sh-$17.4M

KRYS 13F holders ranked 1–100 of 426

Institutional investors reporting a position in Krystal Biotech, Inc. on SEC Form 13F-HR for Q2 2026, ranked by reported value.
#	Institution	Shares	Value	% of portfolio	QoQShares vs Q1 2026
1	FMR#1 · 4,418,197 sh	4,418,197	$1.6B	0.07%	+1.0%
2	BlackRock#2 · 4,181,432 sh	4,181,432	$1.6B	0.02%	+6.1%
3	Avoro Capital Advisors#3 · 2,888,888 sh	2,888,888	$1.1B	9.64%	0.0%
4	VANGUARD PORTFOLIO MANAGEMENT#4 · 1,574,905 sh	1,574,905	$585.3M	0.03%	+8.1%
5	STATE STREET#5 · 1,351,158 sh	1,351,158	$502.2M	0.01%	+2.8%
6	VANGUARD CAPITAL MANAGEMENT#6 · 1,240,567 sh	1,240,567	$461.1M	<0.01%	+6.5%
7	Soleus Capital Management, L.P.#7 · 939,254 sh	939,254	$349.1M	12.03%	-18.5%
8	Capital World Investors#8 · 777,843 sh	777,843	$289.1M	0.03%	-5.7%
9	GEODE CAPITAL MANAGEMENT#9 · 698,993 sh	698,993	$259.8M	0.01%	+8.5%
10	PRICE T ROWE ASSOCIATES#10 · 687,400 sh	687,400	$255.5M	0.03%	+41.7%
11	Hood River Capital Management#11 · 663,375 sh	663,375	$246.6M	1.79%	+7.1%
12	Redmile Group#12 · 632,005 sh	632,005	$234.9M	15.77%	-6.2%
13	WILLIAM BLAIR INVESTMENT MANAGEMENT#13 · 570,153 sh	570,153	$211.9M	0.64%	+40.0%
14	Frazier Life Sciences Management, L.P.#14 · 481,307 sh	481,307	$178.9M	3.90%	0.0%
15	DIMENSIONAL FUND ADVISORS#15 · 476,038 sh	476,038	$176.9M	0.03%	+1.5%
16	FIRST ADVISORS#16 · 324,900 sh	324,900	$120.8M	0.07%	-7.3%
17	Invesco Ltd.#17 · 324,755 sh	324,755	$120.7M	<0.01%	+29.2%
18	GOLDMAN SACHS GROUP#18 · 298,841 sh	298,841	$111.1M	<0.01%	+39.0%
19	NORTHERN#19 · 283,784 sh	283,784	$105.5M	0.01%	+12.4%
20	FRANKLIN RESOURCES#20 · 261,917 sh	261,917	$97.3M	0.02%	+46.1%
21	NORGES BANK#21 · 259,030 sh	259,030	$96.3M	<0.01%	—
22	Jupiter Topco#22 · 256,665 sh	256,665	$95.4M	0.04%	—
23	BANK OF AMERICA#23 · 256,431 sh	256,431	$95.3M	<0.01%	-1.6%
24	CHARLES SCHWAB INVESTMENT MANAGEMENT#24 · 254,828 sh	254,828	$94.7M	0.01%	+5.3%
25	MORGAN STANLEY#25 · 235,491 sh	235,491	$87.5M	<0.01%	+12.6%
26	VANGUARD FIDUCIARY#26 · 189,528 sh	189,528	$70.4M	0.02%	+5.8%
27	PRINCIPAL FINANCIAL GROUP#27 · 169,550 sh	169,550	$63.0M	0.03%	+4.6%
28	Bank of New York Mellon#28 · 163,610 sh	163,610	$60.8M	0.01%	+9.6%
29	RAYMOND JAMES FINANCIAL#29 · 158,675 sh	158,675	$59.0M	0.02%	+1.7%
30	Woodline Partners#30 · 150,616 sh	150,616	$56.0M	0.17%	0.0%
31	UBS Group AG#31 · 148,316 sh	148,316	$55.1M	<0.01%	+3.3%
32	Nuveen#32 · 146,520 sh	146,520	$54.5M	0.01%	+2.2%
33	BRAIDWELL#33 · 128,975 sh	128,975	$47.9M	1.77%	-29.3%
34	VOYA INVESTMENT MANAGEMENT#34 · 124,442 sh	124,442	$46.3M	0.04%	+14.8%
35	TimesSquare Capital Management#35 · 111,545 sh	111,545	$41.5M	0.61%	-0.7%
36	Pictet Asset Management Holding SA#36 · 107,798 sh	107,798	$40.1M	0.04%	-2.6%
37	PUBLIC SECTOR PENSION INVESTMENT BOARD#37 · 105,515 sh	105,515	$39.2M	0.10%	+14.3%
38	1832 Asset Management L.P.#38 · 99,300 sh	99,300	$36.9M	0.02%	+133.1%
39	WESTFIELD CAPITAL MANAGEMENT#39 · 98,707 sh	98,707	$36.7M	0.12%	New
40	BNP PARIBAS FINANCIAL MARKETS#40 · 92,234 sh	92,234	$34.3M	0.01%	-0.9%
41	Handelsbanken Fonder AB#41 · 90,407 sh	90,407	$33.6M	0.10%	-1.1%
42	JPMORGAN CHASE#42 · 87,342 sh	87,342	$33.5M	<0.01%	-11.9%
43	ORBIMED ADVISORS#43 · 83,200 sh	83,200	$30.9M	0.57%	+20.4%
44	S Squared Technology#44 · 77,545 sh	77,545	$28.8M	8.94%	-10.1%
45	Bellevue Group AG#45 · 77,530 sh	77,530	$28.8M	0.61%	-83.9%
46	Biondo Investment Advisors#46 · 70,945 sh	70,945	$26.4M	3.23%	-1.5%
47	SEGALL BRYANT & HAMILL#47 · 65,211 sh	65,211	$24.2M	0.29%	New
48	RHUMBLINE ADVISERS#48 · 61,236 sh	61,236	$22.8M	0.02%	-10.1%
49	RENAISSANCE TECHNOLOGIES#49 · 59,680 sh	59,680	$22.2M	0.03%	+521.7%
50	Legal & General Group Plc#50 · 58,580 sh	58,580	$21.8M	<0.01%	-0.8%
51	C WorldWide Group Holding A/S#51 · 57,809 sh	57,809	$21.5M	0.52%	-14.7%
52	CITIGROUP#52 · 56,016 sh	56,016	$20.8M	<0.01%	+79.7%
53	Bridgewater Associates#53 · 54,489 sh	54,489	$20.3M	0.08%	+17.5%
54	SEI INVESTMENTS#54 · 54,040 sh	54,040	$20.1M	0.02%	+16.0%
55	Russell Investments Group, Ltd.#55 · 52,621 sh	52,621	$19.6M	0.02%	+100.8%
56	Allspring Global Investments#56 · 52,407 sh	52,407	$19.5M	0.03%	+2017.5%
57	Neuberger Berman Group#57 · 51,876 sh	51,876	$19.3M	0.01%	+56.8%
58	AMERIPRISE FINANCIAL#58 · 48,790 sh	48,790	$18.1M	<0.01%	-2.1%
59	Palisades Investment Partners#59 · 47,801 sh	47,801	$17.8M	5.05%	+5.3%
60	ACT CAPITAL MANAGEMENT#60 · 45,000 sh	45,000	$16.7M	10.93%	-25.6%
61	VICTORY CAPITAL MANAGEMENT#61 · 44,935 sh	44,935	$16.7M	<0.01%	+10.4%
62	FEDERATED HERMES#62 · 43,848 sh	43,848	$16.3M	0.02%	+23.5%
63	Swiss National Bank#63 · 41,360 sh	41,360	$15.4M	<0.01%	-3.8%
64	GILDER GAGNON HOWE#64 · 40,296 sh	40,296	$15.0M	0.15%	+0.4%
65	CONGRESS ASSET MANAGEMENT#65 · 40,134 sh	40,134	$14.9M	—	New
66	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#66 · 38,697 sh	38,697	$14.4M	<0.01%	+4.8%
67	SEB Asset Management AB#67 · 37,731 sh	37,731	$14.0M	0.05%	-18.6%
68	WELLINGTON MANAGEMENT GROUP LLP#68 · 36,936 sh	36,936	$13.7M	<0.01%	+261.2%
69	Life Cycle Investment Partners Ltd#69 · 35,124 sh	35,124	$13.1M	0.06%	New
70	WELLS FARGO & COMPANY#70 · 34,502 sh	34,502	$12.8M	<0.01%	+130.2%
71	NEW YORK STATE COMMON RETIREMENT FUND#71 · 34,033 sh	34,033	$12.6M	0.02%	+8.6%
72	Granite Investment Partners#72 · 32,837 sh	32,837	$12.2M	0.63%	+35.2%
73	PRUDENTIAL FINANCIAL#73 · 32,662 sh	32,662	$12.1M	0.01%	+10.2%
74	MUTUAL OF AMERICA CAPITAL MANAGEMENT#74 · 31,998 sh	31,998	$11.9M	—	-10.8%
75	DEUTSCHE BANK AG\#75 · 31,836 sh	31,836	$11.8M	<0.01%	+28.2%
76	Corient Private Wealth#76 · 30,558 sh	30,558	$11.4M	0.02%	+767.4%
77	Fisher Asset Management#77 · 27,676 sh	27,676	$10.3M	<0.01%	-0.4%
78	MANUFACTURERS LIFE INSURANCE COMPANY, THE#78 · 25,867 sh	25,867	$9.6M	<0.01%	-28.3%
79	abrdn plc#79 · 25,141 sh	25,141	$9.3M	0.01%	-16.6%
80	HealthInvest Partners AB#80 · 24,019 sh	24,019	$8.9M	2.40%	-36.1%
81	ALLIANCEBERNSTEIN L.P.#81 · 34,039 sh	34,039	$8.8M	<0.01%	+6.6%
82	TD ASSET MANAGEMENT#82 · 22,712 sh	22,712	$8.4M	<0.01%	-47.6%
83	Elmind Capital#83 · 22,000 sh	22,000	$8.2M	2.05%	0.0%
84	GREAT WEST LIFE ASSURANCE#84 · 21,711 sh	21,711	$8.1M	0.01%	+1.4%
85	VANGUARD ASSET MANAGEMENT, Ltd#85 · 21,390 sh	21,390	$8.0M	<0.01%	+3.8%
86	VIRGINIA RETIREMENT SYSTEMS ET Al#86 · 20,800 sh	20,800	$7.7M	0.03%	+118.9%
87	Creative Planning#87 · 20,318 sh	20,318	$7.6M	<0.01%	+27.5%
88	BESSEMER GROUP#88 · 20,285 sh	20,285	$7.5M	0.01%	0.0%
89	Pinnacle Financial Partners#89 · 20,243 sh	20,243	$7.5M	0.05%	+0.3%
90	TFG Asset Management GP Ltd#90 · 19,668 sh	19,668	$7.3M	1.15%	0.0%
91	Lisanti Capital Growth#91 · 19,050 sh	19,050	$7.1M	1.56%	+2.9%
92	GW&K Investment Management#92 · 18,295 sh	18,295	$6.8M	0.05%	-4.9%
93	THRIVENT FINANCIAL FOR LUTHERANS#93 · 17,229 sh	17,229	$6.4M	0.01%	0.0%
94	VAN ECK ASSOCIATES#94 · 17,071 sh	17,071	$6.3M	<0.01%	New
95	NEW YORK STATE TEACHERS RETIREMENT SYSTEM#95 · 16,801 sh	16,801	$6.2M	—	+7.4%
96	ADAR1 Capital Management#96 · 16,420 sh	16,420	$6.1M	0.28%	-18.0%
97	Cinctive Capital Management#97 · 16,367 sh	16,367	$6.1M	0.22%	+469.5%
98	Rhenman & Partners Asset Management AB#98 · 16,325 sh	16,325	$6.1M	0.57%	-2.1%
99	Informed Momentum#99 · 16,227 sh	16,227	$6.0M	0.54%	-1.6%
100	Mediolanum International Funds Ltd#100 · 15,940 sh	15,940	$6.0M	0.05%	New

Funds that sold out of KRYS in Q2 2026 (37)

Held KRYS at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.

Institutions that held KRYS in Q1 2026 and reported no position in Q2 2026.
Institution	Shares sold	Value in Q1 2026
MARSHALL WACE, LLP68,343 sh	68,343	$17.7M
ZACKS INVESTMENT MANAGEMENT17,919 sh	17,919	$4.6M
Campbell & Investment Adviser17,795 sh	17,795	$4.6M
TUDOR INVESTMENT ET AL14,476 sh	14,476	$3.7M
Aquatic Capital Management8,257 sh	8,257	$2.1M
Decheng Capital7,300 sh	7,300	$1.9M
FORA Capital5,732 sh	5,732	$1.5M
HEALTHCARE OF ONTARIO PENSION PLAN FUND4,664 sh	4,664	$1.2M
MILLENNIUM MANAGEMENT4,119 sh	4,119	$1.1M
Quadrature Capital Ltd3,189 sh	3,189	$823.8K
Blackstone2,246 sh	2,246	$580.2K
Entropy Technologies2,200 sh	2,200	$568.3K
NATIXIS1,736 sh	1,736	$448.4K
Cynosure Management1,649 sh	1,649	$426.0K
IMC-Chicago1,591 sh	1,591	$411.0K
Hudson Bay Capital Management1,300 sh	1,300	$335.8K
Squarepoint Ops1,138 sh	1,138	$294.0K
GTS SECURITIES1,108 sh	1,108	$286.2K
FARALLON CAPITAL MANAGEMENT1,000 sh	1,000	$258.3K
D. E. Shaw996 sh	996	$257.3K
Private Advisor Group947 sh	947	$244.6K
COLDSTREAM CAPITAL MANAGEMENT939 sh	939	$242.6K
DRW Securities857 sh	857	$221.4K
QUADRANT CAPITAL GROUP472 sh	472	$109.9K
CULLEN/FROST BANKERS187 sh	187	$48.3K
Sound Income Strategies137 sh	137	$35.5K
Western Wealth Management132 sh	132	$34.1K
TWIN PEAKS WEALTH ADVISORS105 sh	105	$27.1K
Steward Partners Investment Advisory100 sh	100	$25.8K
Dauntless Investment Group73 sh	73	$18.9K
SIMPLEX TRADING50 sh	50	$12.9K
Root Financial Partners17 sh	17	$4.4K
NORTHWESTERN MUTUAL WEALTH MANAGEMENT13 sh	13	$3.4K
Rachor Investment Advisory Services8 sh	8	$2.1K
Ronald Blue4 sh	4	$1.0K
Vermillion Wealth Management3 sh	3	$775.00
Ameritas Advisory Services1 sh	1	$258.00

Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.