Karyopharm Therapeutics Inc. (KPTI) — Institutional Holders, Q2 2026
97 institutional investment managers reported a KPTI position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $206.8M. Every filer is listed below, ranked by position value. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
KPTI in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- ACORN CAPITAL ADVISORSAdded · +1,230,287 sh+$12.0M
- BlackRockAdded · +1,173,900 sh+$11.5M
- Kalehua Capital ManagementNew · +685,644 sh+$6.7M
- NEA Management CompanyNew · +576,780 sh+$5.6M
- TWO SIGMA INVESTMENTSAdded · +544,032 sh+$5.3M
Biggest sellers
- Commodore CapitalSold out · -1,950,000 sh-$19.1M
- T. Rowe Price Investment ManagementTrimmed · -755,781 sh-$7.4M
- Ikarian CapitalSold out · -733,435 sh-$7.2M
- ADAGE CAPITAL PARTNERS GP, L.L.C.Trimmed · -285,000 sh-$2.8M
- BOOTHBAY FUND MANAGEMENTSold out · -213,810 sh-$2.1M
KPTI 13F holders ranked 1–97 of 97
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P.#1 · 1,917,354 sh | 1,917,354 | $18.7M | 0.16% | 0.0% |
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C.#2 · 1,521,322 sh | 1,521,322 | $14.9M | 0.02% | -15.8% |
| 3 | ACORN CAPITAL ADVISORS#3 · 1,518,113 sh | 1,518,113 | $14.8M | 4.05% | +427.4% |
| 4 | GOLDMAN SACHS GROUP#4 · 1,424,658 sh | 1,424,658 | $13.9M | <0.01% | +50.3% |
| 5 | BlackRock#5 · 1,418,799 sh | 1,418,799 | $13.9M | <0.01% | +479.3% |
| 6 | VANGUARD CAPITAL MANAGEMENT#6 · 958,979 sh | 958,979 | $9.4M | <0.01% | +29.6% |
| 7 | Catalio Capital Management#7 · 940,855 sh | 940,855 | $9.2M | 1.73% | +4.8% |
| 8 | Avidity Partners Management#8 · 924,487 sh | 924,487 | $9.0M | 1.45% | +99.4% |
| 9 | T. Rowe Price Investment Management#9 · 786,309 sh | 786,309 | $7.7M | <0.01% | -49.0% |
| 10 | TWO SIGMA INVESTMENTS#10 · 695,264 sh | 695,264 | $6.8M | <0.01% | +359.7% |
| 11 | Kalehua Capital Management#11 · 685,644 sh | 685,644 | $6.7M | 4.80% | New |
| 12 | NEA Management Company#12 · 576,780 sh | 576,780 | $5.6M | 0.35% | New |
| 13 | GEODE CAPITAL MANAGEMENT#13 · 531,231 sh | 531,231 | $5.2M | <0.01% | +157.7% |
| 14 | Ghisallo Capital Management#14 · 500,000 sh | 500,000 | $4.9M | 0.10% | New |
| 15 | Soleus Capital Management, L.P.#15 · 440,000 sh | 440,000 | $4.3M | 0.15% | 0.0% |
| 16 | UBS Group AG#16 · 353,545 sh | 353,545 | $3.5M | <0.01% | +82.2% |
| 17 | STATE STREET#17 · 325,991 sh | 325,991 | $3.2M | <0.01% | +303.7% |
| 18 | Affinity Asset Advisors#18 · 312,500 sh | 312,500 | $3.1M | 0.14% | -37.5% |
| 19 | Brevan Howard Capital Management#19 · 309,817 sh | 309,817 | $3.0M | 0.02% | +45.9% |
| 20 | MILLENNIUM MANAGEMENT#20 · 305,676 sh | 305,676 | $3.0M | <0.01% | -27.3% |
| 21 | Boxer Capital Management#21 · 302,536 sh | 302,536 | $3.0M | 0.22% | 0.0% |
| 22 | DAVIDSON KEMPNER CAPITAL MANAGEMENT#22 · 300,000 sh | 300,000 | $2.9M | 0.03% | 0.0% |
| 23 | ACADIAN ASSET MANAGEMENT#23 · 298,997 sh | 298,997 | $2.9M | <0.01% | +20.1% |
| 24 | SILVERARC CAPITAL MANAGEMENT#24 · 297,460 sh | 297,460 | $2.9M | 0.30% | New |
| 25 | Eversept Partners#25 · 276,174 sh | 276,174 | $2.7M | 0.14% | 0.0% |
| 26 | JPMORGAN CHASE#26 · 207,609 sh | 207,609 | $2.1M | <0.01% | New |
| 27 | MORGAN STANLEY#27 · 202,506 sh | 202,506 | $2.0M | <0.01% | +990.5% |
| 28 | Trexquant Investment#28 · 188,368 sh | 188,368 | $1.8M | 0.01% | -27.0% |
| 29 | BNP PARIBAS FINANCIAL MARKETS#29 · 188,038 sh | 188,038 | $1.8M | <0.01% | New |
| 30 | BARCLAYS PLC#30 · 165,904 sh | 165,904 | $1.6M | <0.01% | +2134.7% |
| 31 | NORTHERN#31 · 160,006 sh | 160,006 | $1.6M | <0.01% | +315.0% |
| 32 | VANGUARD FIDUCIARY#32 · 145,401 sh | 145,401 | $1.4M | <0.01% | +26.5% |
| 33 | VANGUARD PORTFOLIO MANAGEMENT#33 · 134,818 sh | 134,818 | $1.3M | <0.01% | New |
| 34 | MARSHALL WACE, LLP#34 · 128,451 sh | 128,451 | $1.3M | <0.01% | 0.0% |
| 35 | RENAISSANCE TECHNOLOGIES#35 · 108,214 sh | 108,214 | $1.1M | <0.01% | +2.7% |
| 36 | C WorldWide Group Holding A/S#36 · 100,000 sh | 100,000 | $977.0K | 0.02% | 0.0% |
| 37 | Jump Financial#37 · 94,000 sh | 94,000 | $918.4K | <0.01% | -64.1% |
| 38 | Invesco Ltd.#38 · 90,304 sh | 90,304 | $882.3K | <0.01% | +439.5% |
| 39 | Connor, Clark & Lunn Investment Management Ltd.#39 · 76,397 sh | 76,397 | $746.4K | <0.01% | -3.4% |
| 40 | BRIDGEWAY CAPITAL MANAGEMENT#40 · 71,873 sh | 71,873 | $702.2K | 0.01% | 0.0% |
| 41 | J. Goldman#41 · 67,500 sh | 67,500 | $659.5K | 0.02% | New |
| 42 | Squarepoint Ops#42 · 63,801 sh | 63,801 | $623.3K | <0.01% | New |
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT#43 · 61,943 sh | 61,943 | $605.2K | <0.01% | +361.3% |
| 44 | ROYAL BANK OF CANADA#44 · 60,430 sh | 60,430 | $590.0K | <0.01% | +0.1% |
| 45 | Bank of New York Mellon#45 · 57,262 sh | 57,262 | $559.4K | <0.01% | +402.3% |
| 46 | Susquehanna Portfolio Strategies#46 · 54,545 sh | 54,545 | $532.9K | <0.01% | +118.0% |
| 47 | XTX Topco Ltd#47 · 53,272 sh | 53,272 | $520.5K | <0.01% | -67.6% |
| 48 | CITADEL ADVISORS#48 · 52,069 sh | 52,069 | $508.7K | <0.01% | New |
| 49 | BANK OF AMERICA#49 · 49,924 sh | 49,924 | $487.8K | 0.00% | +156.4% |
| 50 | Birchview Capital#50 · 42,952 sh | 42,952 | $419.6K | 0.20% | -48.8% |
| 51 | CITIGROUP#51 · 37,917 sh | 37,917 | $370.4K | <0.01% | +667.4% |
| 52 | Nuveen#52 · 37,868 sh | 37,868 | $370.0K | <0.01% | New |
| 53 | Engineers Gate Manager#53 · 33,966 sh | 33,966 | $331.8K | <0.01% | -69.8% |
| 54 | NOMURA ASSET MANAGEMENT INTERNATIONAL#54 · 33,333 sh | 33,333 | $326.0K | <0.01% | New |
| 55 | JANE STREET GROUP#55 · 33,173 sh | 33,173 | $324.1K | 0.00% | -68.7% |
| 56 | TORONTO DOMINION BANK#56 · 30,930 sh | 30,930 | $302.2K | <0.01% | New |
| 57 | SILVERBACK ASSET MANAGEMENT#57 · 30,000 sh | 30,000 | $293.1K | 0.03% | -53.8% |
| 58 | Baird Financial Group#58 · 29,791 sh | 29,791 | $291.1K | <0.01% | 0.0% |
| 59 | PRICE T ROWE ASSOCIATES#59 · 27,225 sh | 27,225 | $266.0K | 0.00% | +150.1% |
| 60 | ExodusPoint Capital Management#60 · 26,582 sh | 26,582 | $259.7K | <0.01% | New |
| 61 | China Universal Asset Management , Ltd.#61 · 25,000 sh | 25,000 | $244.3K | 0.01% | -16.7% |
| 62 | SIMPLEX TRADING#62 · 24,086 sh | 24,086 | $235.3K | <0.01% | New |
| 63 | RHUMBLINE ADVISERS#63 · 23,467 sh | 23,467 | $229.3K | <0.01% | New |
| 64 | SUSQUEHANNA FUNDAMENTAL INVESTMENTS#64 · 23,265 sh | 23,265 | $227.3K | <0.01% | New |
| 65 | Velan Capital Investment Management#65 · 20,000 sh | 20,000 | $195.4K | 0.12% | +33.3% |
| 66 | DEUTSCHE BANK AG\#66 · 19,425 sh | 19,425 | $189.8K | <0.01% | New |
| 67 | WELLS FARGO & COMPANY#67 · 16,903 sh | 16,903 | $165.1K | 0.00% | New |
| 68 | SEI INVESTMENTS#68 · 15,083 sh | 15,083 | $147.4K | <0.01% | New |
| 69 | HSBC PLC#69 · 13,750 sh | 13,750 | $137.4K | <0.01% | +19.6% |
| 70 | Headlands Technologies#70 · 12,113 sh | 12,113 | $118.3K | 0.01% | New |
| 71 | MetLife Investment Management#71 · 12,017 sh | 12,017 | $117.4K | <0.01% | New |
| 72 | Virtu Financial#72 · 10,728 sh | 10,728 | $105.0K | <0.01% | New |
| 73 | Y-Intercept (Hong Kong) Ltd#73 · 10,375 sh | 10,375 | $101.4K | — | New |
| 74 | Quadrature Capital Ltd#74 · 10,296 sh | 10,296 | $100.6K | <0.01% | New |
| 75 | MIRAE ASSET GLOBAL ETFS Ltd.#75 · 9,171 sh | 9,171 | $89.6K | <0.01% | New |
| 76 | FMR#76 · 8,936 sh | 8,936 | $87.3K | 0.00% | +1243.8% |
| 77 | Vanguard Global Advisers#77 · 8,207 sh | 8,207 | $80.2K | 0.00% | 0.0% |
| 78 | Police & Firemen's Retirement System of New Jersey#78 · 5,874 sh | 5,874 | $57.4K | <0.01% | New |
| 79 | NEW YORK STATE COMMON RETIREMENT FUND#79 · 5,600 sh | 5,600 | $54.7K | <0.01% | New |
| 80 | TD Waterhouse Canada#80 · 5,707 sh | 5,707 | $54.5K | — | +78.2% |
| 81 | Legal & General Group Plc#81 · 1,935 sh | 1,935 | $18.9K | 0.00% | New |
| 82 | Ameritas Investment Partners#82 · 1,808 sh | 1,808 | $17.7K | <0.01% | New |
| 83 | Russell Investments Group, Ltd.#83 · 1,592 sh | 1,592 | $15.6K | 0.00% | New |
| 84 | Tower Research Capital (TRC)#84 · 1,259 sh | 1,259 | $12.3K | <0.01% | New |
| 85 | OSAIC#85 · 402 sh | 402 | $3.9K | 0.00% | 0.0% |
| 86 | Sterling Capital Management#86 · 352 sh | 352 | $3.4K | — | New |
| 87 | HARBOUR INVESTMENTS#87 · 285 sh | 285 | $2.8K | 0.00% | 0.0% |
| 88 | Quent Capital#88 · 166 sh | 166 | $1.6K | <0.01% | -29.4% |
| 89 | Integrated Wealth Concepts#89 · 134 sh | 134 | $1.3K | 0.00% | New |
| 90 | MB, LEVIS & ASSOCIATES#90 · 100 sh | 100 | $977.00 | — | 0.0% |
| 91 | SBI Securities , Ltd.#91 · 67 sh | 67 | $655.00 | — | 0.0% |
| 92 | Activest Wealth Management#92 · 66 sh | 66 | $645.00 | — | 0.0% |
| 93 | Allworth Financial#93 · 26 sh | 26 | $255.00 | 0.00% | 0.0% |
| 94 | Caitong International Asset Management , Ltd#94 · 14 sh | 14 | $137.00 | 0.00% | New |
| 95 | West Branch Capital#95 · 3 sh | 3 | $30.00 | — | 0.0% |
| 96 | PlanVest Financial#96 · 1 sh | 1 | $10.00 | 0.00% | 0.0% |
| 97 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM#97 · 274 sh | 274 | — | — | New |
Funds that sold out of KPTI in Q2 2026 (14)
Held KPTI at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| Commodore Capital1,950,000 sh | 1,950,000 | $10.9M |
| Ikarian Capital733,435 sh | 733,435 | $4.1M |
| BOOTHBAY FUND MANAGEMENT213,810 sh | 213,810 | $1.2M |
| GROUP ONE TRADING, L.P.191,527 sh | 191,527 | $1.1M |
| ADAR1 Capital Management136,736 sh | 136,736 | $761.6K |
| BALYASNY ASSET MANAGEMENT L.P.70,748 sh | 70,748 | $394.1K |
| TFG Asset Management GP Ltd52,984 sh | 52,984 | $295.1K |
| DAFNA Capital Management45,800 sh | 45,800 | $255.1K |
| Zimmer Partners37,500 sh | 37,500 | $208.9K |
| Centiva Capital30,210 sh | 30,210 | $168.3K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP24,138 sh | 24,138 | $134.4K |
| OMERS ADMINISTRATION19,400 sh | 19,400 | $108.1K |
| Rockefeller Capital Management L.P.733 sh | 733 | $4.1K |
| Advisory Services Network12 sh | 12 | $67.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.