Edgewise Therapeutics, Inc. (EWTX) — Institutional Holders, Q2 2026
227 institutional investment managers reported a EWTX position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $4.8B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
EWTX in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- FMRAdded · +4,472,083 sh+$181.7M
- Paradigm Biocapital AdvisorsAdded · +2,850,417 sh+$115.8M
- PRICE T ROWE ASSOCIATESAdded · +747,091 sh+$30.4M
- Tyro Capital ManagementNew · +612,965 sh+$24.9M
- ADAGE CAPITAL PARTNERS GP, L.L.C.New · +462,000 sh+$18.8M
Biggest sellers
- BAKER BROS. ADVISORSTrimmed · -2,874,221 sh-$116.8M
- RA CAPITAL MANAGEMENT, L.P.Trimmed · -2,035,707 sh-$82.7M
- Bellevue Group AGSold out · -1,528,518 sh-$62.1M
- Siren, L.L.C.Trimmed · -1,245,634 sh-$50.6M
- UBS Group AGTrimmed · -1,136,158 sh-$46.2M
EWTX 13F holders ranked 1–100 of 227
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS#1 · 15,518,492 sh | 15,518,492 | $630.5M | 11.68% | 0.0% |
| 2 | Paradigm Biocapital Advisors#2 · 10,215,455 sh | 10,215,455 | $415.1M | 7.77% | +38.7% |
| 3 | RA CAPITAL MANAGEMENT, L.P.#3 · 8,392,730 sh | 8,392,730 | $341.0M | 2.96% | -19.5% |
| 4 | BlackRock#4 · 6,606,336 sh | 6,606,336 | $268.4M | <0.01% | +2.1% |
| 5 | Jupiter Topco#5 · 6,075,331 sh | 6,075,331 | $246.9M | 0.10% | — |
| 6 | FMR#6 · 5,489,135 sh | 5,489,135 | $223.0M | <0.01% | +439.7% |
| 7 | Novo A/S#7 · 5,350,000 sh | 5,350,000 | $217.4M | 12.62% | 0.0% |
| 8 | DRIEHAUS CAPITAL MANAGEMENT#8 · 4,728,623 sh | 4,728,623 | $192.1M | 1.11% | +5.6% |
| 9 | PERCEPTIVE ADVISORS#9 · 4,373,974 sh | 4,373,974 | $177.7M | 2.67% | -1.1% |
| 10 | VANGUARD CAPITAL MANAGEMENT#10 · 3,860,670 sh | 3,860,670 | $156.9M | <0.01% | +1.9% |
| 11 | BAKER BROS. ADVISORS#11 · 3,701,719 sh | 3,701,719 | $150.4M | 0.75% | -43.7% |
| 12 | Siren, L.L.C.#12 · 3,184,629 sh | 3,184,629 | $129.4M | 2.62% | -28.1% |
| 13 | Cormorant Asset Management#13 · 2,510,000 sh | 2,510,000 | $102.0M | 5.23% | -23.0% |
| 14 | GEODE CAPITAL MANAGEMENT#14 · 2,174,051 sh | 2,174,051 | $88.3M | <0.01% | +21.5% |
| 15 | Integral Health Asset Management#15 · 2,000,000 sh | 2,000,000 | $81.3M | 3.21% | +25.0% |
| 16 | BRAIDWELL#16 · 1,996,965 sh | 1,996,965 | $81.1M | 3.00% | -14.9% |
| 17 | MORGAN STANLEY#17 · 1,948,597 sh | 1,948,597 | $79.2M | <0.01% | -13.2% |
| 18 | STATE STREET#18 · 1,827,927 sh | 1,827,927 | $74.3M | <0.01% | +6.5% |
| 19 | ALLIANCEBERNSTEIN L.P.#19 · 2,119,024 sh | 2,119,024 | $66.7M | 0.02% | +23.0% |
| 20 | MPM BioImpact#20 · 1,620,780 sh | 1,620,780 | $65.9M | 4.02% | -2.4% |
| 21 | BANK OF AMERICA#21 · 1,558,260 sh | 1,558,260 | $63.3M | <0.01% | +17.4% |
| 22 | Qube Research & Technologies Ltd#22 · 1,252,507 sh | 1,252,507 | $50.9M | 0.05% | +51.7% |
| 23 | DIMENSIONAL FUND ADVISORS#23 · 1,139,726 sh | 1,139,726 | $46.3M | <0.01% | -6.6% |
| 24 | AMERICAN CENTURY COMPANIES#24 · 1,127,078 sh | 1,127,078 | $45.8M | 0.02% | -1.8% |
| 25 | First Light Asset Management#25 · 1,095,171 sh | 1,095,171 | $44.5M | 2.70% | +9.3% |
| 26 | VICTORY CAPITAL MANAGEMENT#26 · 902,870 sh | 902,870 | $36.7M | 0.02% | +14.4% |
| 27 | PRICE T ROWE ASSOCIATES#27 · 816,518 sh | 816,518 | $33.2M | <0.01% | +1076.1% |
| 28 | VANGUARD PORTFOLIO MANAGEMENT#28 · 786,456 sh | 786,456 | $32.0M | <0.01% | +41.1% |
| 29 | NORTHERN#29 · 671,270 sh | 671,270 | $27.3M | <0.01% | +16.4% |
| 30 | abrdn plc#30 · 647,926 sh | 647,926 | $26.3M | 0.04% | -21.6% |
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT#31 · 620,532 sh | 620,532 | $25.2M | <0.01% | +4.1% |
| 32 | Tyro Capital Management#32 · 612,965 sh | 612,965 | $24.9M | 5.59% | New |
| 33 | GOLDMAN SACHS GROUP#33 · 599,469 sh | 599,469 | $24.4M | <0.01% | -4.8% |
| 34 | Parkman Healthcare Partners#34 · 577,036 sh | 577,036 | $23.4M | 2.40% | +78.7% |
| 35 | Artisan Partners Limited Partnership#35 · 574,925 sh | 574,925 | $23.4M | 0.04% | -12.8% |
| 36 | VANGUARD FIDUCIARY#36 · 548,285 sh | 548,285 | $22.3M | <0.01% | +5.1% |
| 37 | NORGES BANK#37 · 510,140 sh | 510,140 | $20.7M | <0.01% | — |
| 38 | Opaleye Management#38 · 500,000 sh | 500,000 | $20.3M | 1.84% | 0.0% |
| 39 | CITADEL ADVISORS#39 · 469,707 sh | 469,707 | $19.1M | <0.01% | +9.5% |
| 40 | ADAGE CAPITAL PARTNERS GP, L.L.C.#40 · 462,000 sh | 462,000 | $18.8M | 0.03% | New |
| 41 | Soleus Capital Management, L.P.#41 · 450,889 sh | 450,889 | $18.3M | 0.63% | -68.9% |
| 42 | Nuveen#42 · 414,706 sh | 414,706 | $16.8M | <0.01% | +23.5% |
| 43 | Sofinnova Ventures#43 · 380,923 sh | 380,923 | $15.5M | 0.80% | -1.4% |
| 44 | HEALTHCARE OF ONTARIO PENSION PLAN FUND#44 · 334,014 sh | 334,014 | $13.6M | 0.02% | -17.4% |
| 45 | RAYMOND JAMES FINANCIAL#45 · 317,565 sh | 317,565 | $12.9M | <0.01% | +1513.8% |
| 46 | Squadron Capital Management#46 · 290,000 sh | 290,000 | $11.8M | 3.66% | -17.1% |
| 47 | Universal- Beteiligungs- und Servicegesellschaft mbH#47 · 283,333 sh | 283,333 | $11.5M | 0.02% | 0.0% |
| 48 | DIADEMA PARTNERS#48 · 272,214 sh | 272,214 | $11.1M | 1.40% | New |
| 49 | PRUDENTIAL FINANCIAL#49 · 260,725 sh | 260,725 | $10.6M | 0.01% | +2358.5% |
| 50 | KENNEDY CAPITAL MANAGEMENT#50 · 256,608 sh | 256,608 | $10.4M | 0.18% | -2.9% |
| 51 | Schonfeld Strategic Advisors#51 · 255,202 sh | 255,202 | $10.4M | 0.04% | +157.6% |
| 52 | DEUTSCHE BANK AG\#52 · 244,995 sh | 244,995 | $10.0M | <0.01% | +10.4% |
| 53 | DAFNA Capital Management#53 · 226,819 sh | 226,819 | $9.2M | 1.76% | +102.1% |
| 54 | Woodline Partners#54 · 224,290 sh | 224,290 | $9.1M | 0.03% | 0.0% |
| 55 | Bank of New York Mellon#55 · 212,347 sh | 212,347 | $8.6M | <0.01% | +10.3% |
| 56 | JPMORGAN CHASE#56 · 203,151 sh | 203,151 | $8.5M | <0.01% | +37.7% |
| 57 | PEREGRINE CAPITAL MANAGEMENT#57 · 198,570 sh | 198,570 | $8.1M | 0.26% | -4.8% |
| 58 | SEB Asset Management AB#58 · 194,063 sh | 194,063 | $7.9M | 0.03% | -6.0% |
| 59 | Granahan Investment Management#59 · 193,778 sh | 193,778 | $7.9M | 0.28% | -3.5% |
| 60 | Neuberger Berman Group#60 · 191,195 sh | 191,195 | $7.8M | <0.01% | +13.3% |
| 61 | BARCLAYS PLC#61 · 190,205 sh | 190,205 | $7.7M | <0.01% | +7.3% |
| 62 | D. E. Shaw#62 · 189,115 sh | 189,115 | $7.7M | <0.01% | +80.3% |
| 63 | UBS Group AG#63 · 174,967 sh | 174,967 | $7.1M | <0.01% | -86.7% |
| 64 | ADAR1 Capital Management#64 · 143,199 sh | 143,199 | $5.8M | 0.27% | +58.1% |
| 65 | KVP Capital Advisors#65 · 133,000 sh | 133,000 | $5.4M | 3.97% | 0.0% |
| 66 | Invesco Ltd.#66 · 120,932 sh | 120,932 | $4.9M | <0.01% | -12.6% |
| 67 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#67 · 118,209 sh | 118,209 | $4.8M | <0.01% | +3.0% |
| 68 | Point72 Asset Management, L.P.#68 · 117,262 sh | 117,262 | $4.8M | <0.01% | New |
| 69 | Quantum Private Wealth#69 · 113,380 sh | 113,380 | $4.6M | — | -2.8% |
| 70 | ALPS ADVISORS#70 · 108,795 sh | 108,795 | $4.4M | 0.02% | +24.6% |
| 71 | MOODY ALDRICH PARTNERS#71 · 104,952 sh | 104,952 | $4.3M | 0.77% | -8.1% |
| 72 | Artia Global Partners#72 · 98,800 sh | 98,800 | $4.0M | 0.74% | +50.8% |
| 73 | Swiss National Bank#73 · 96,800 sh | 96,800 | $3.9M | <0.01% | -6.8% |
| 74 | VOYA INVESTMENT MANAGEMENT#74 · 94,671 sh | 94,671 | $3.8M | <0.01% | +141.8% |
| 75 | HSBC PLC#75 · 91,638 sh | 91,638 | $3.7M | <0.01% | New |
| 76 | HighVista Strategies#76 · 90,996 sh | 90,996 | $3.7M | 0.84% | -1.0% |
| 77 | RHUMBLINE ADVISERS#77 · 90,232 sh | 90,232 | $3.7M | <0.01% | +8.0% |
| 78 | Ally Bridge Group (NY)#78 · 83,300 sh | 83,300 | $3.4M | 2.99% | -48.3% |
| 79 | BOOTHBAY FUND MANAGEMENT#79 · 82,734 sh | 82,734 | $3.4M | 0.04% | New |
| 80 | NEW YORK STATE COMMON RETIREMENT FUND#80 · 80,197 sh | 80,197 | $3.3M | <0.01% | -9.8% |
| 81 | WELLS FARGO & COMPANY#81 · 78,898 sh | 78,898 | $3.2M | <0.01% | +212.5% |
| 82 | Russell Investments Group, Ltd.#82 · 77,733 sh | 77,733 | $3.2M | <0.01% | +1082.4% |
| 83 | LEUCADIA NATIONAL#83 · 71,389 sh | 71,389 | $2.9M | 0.02% | New |
| 84 | Persistent Asset Partners Ltd#84 · 69,441 sh | 69,441 | $2.8M | 0.84% | +590.7% |
| 85 | NOMURA ASSET MANAGEMENT INTERNATIONAL#85 · 64,918 sh | 64,918 | $2.6M | <0.01% | -3.7% |
| 86 | DekaBank Deutsche Girozentrale#86 · 80,000 sh | 80,000 | $2.5M | — | 0.0% |
| 87 | CITIGROUP#87 · 59,563 sh | 59,563 | $2.4M | <0.01% | +221.7% |
| 88 | TUDOR INVESTMENT ET AL#88 · 56,934 sh | 56,934 | $2.3M | <0.01% | +90.5% |
| 89 | STATE OF WISCONSIN INVESTMENT BOARD#89 · 56,910 sh | 56,910 | $2.3M | <0.01% | +73.0% |
| 90 | HighMark Wealth Management#90 · 53,179 sh | 53,179 | $2.2M | 0.72% | 0.0% |
| 91 | TWO SIGMA INVESTMENTS#91 · 49,548 sh | 49,548 | $2.0M | <0.01% | -2.6% |
| 92 | SEI INVESTMENTS#92 · 47,543 sh | 47,543 | $1.9M | <0.01% | -3.1% |
| 93 | ALGERT GLOBAL#93 · 47,240 sh | 47,240 | $1.9M | 0.02% | +45.3% |
| 94 | XTX Topco Ltd#94 · 45,832 sh | 45,832 | $1.9M | 0.02% | +139.9% |
| 95 | Legal & General Group Plc#95 · 44,688 sh | 44,688 | $1.8M | <0.01% | +5.1% |
| 96 | GSA CAPITAL PARTNERS LLP#96 · 44,466 sh | 44,466 | $1.8M | 0.11% | New |
| 97 | BNP PARIBAS FINANCIAL MARKETS#97 · 43,587 sh | 43,587 | $1.8M | <0.01% | +82.3% |
| 98 | MetLife Investment Management#98 · 41,804 sh | 41,804 | $1.7M | <0.01% | +9.8% |
| 99 | MANUFACTURERS LIFE INSURANCE COMPANY, THE#99 · 40,757 sh | 40,757 | $1.7M | <0.01% | +15.0% |
| 100 | Ensign Peak Advisors#100 · 40,379 sh | 40,379 | $1.6M | <0.01% | New |
Funds that sold out of EWTX in Q2 2026 (27)
Held EWTX at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| Bellevue Group AG1,528,518 sh | 1,528,518 | $48.1M |
| Candriam S.C.A.447,416 sh | 447,416 | $14.1M |
| MILLENNIUM MANAGEMENT342,867 sh | 342,867 | $10.8M |
| StemPoint Capital290,864 sh | 290,864 | $9.2M |
| Sio Capital Management268,986 sh | 268,986 | $8.5M |
| AMERIPRISE FINANCIAL200,661 sh | 200,661 | $6.3M |
| EVENTIDE ASSET MANAGEMENT149,863 sh | 149,863 | $4.7M |
| Freestone Grove Partners148,426 sh | 148,426 | $4.7M |
| SCHRODER INVESTMENT MANAGEMENT GROUP145,286 sh | 145,286 | $4.4M |
| Ishara Investments49,200 sh | 49,200 | $1.5M |
| Jain Global46,401 sh | 46,401 | $1.5M |
| SILVERARC CAPITAL MANAGEMENT42,615 sh | 42,615 | $1.3M |
| Caption Management38,675 sh | 38,675 | $1.2M |
| Headlands Technologies13,767 sh | 13,767 | $433.7K |
| Hudson Bay Capital Management12,930 sh | 12,930 | $407.3K |
| Seven Fleet Capital Management11,701 sh | 11,701 | $368.6K |
| SFMG10,000 sh | 10,000 | $315.0K |
| Elmind Capital10,000 sh | 10,000 | $315.0K |
| Atom Investors9,941 sh | 9,941 | $313.1K |
| SG Americas Securities3,804 sh | 3,804 | $120.0K |
| Cygnus Capital Advisors3,427 sh | 3,427 | $108.0K |
| SIMPLEX TRADING1,832 sh | 1,832 | $57.7K |
| QUADRANT CAPITAL GROUP12 sh | 12 | $49.2K |
| Winthrop Capital Management1,377 sh | 1,377 | $43.0K |
| SUMMIT SECURITIES GROUP678 sh | 678 | $21.4K |
| EASTERN BANK223 sh | 223 | $7.0K |
| MAI Capital Management9 sh | 9 | $284.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.