Design Therapeutics, Inc. (DSGN) — Institutional Holders, Q2 2026
137 institutional investment managers reported a DSGN position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $626.5M. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
DSGN in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- Frazier Life Sciences Management, L.P.New · +1,809,854 sh+$26.2M
- Trails Edge Capital PartnersAdded · +1,149,269 sh+$16.6M
- Logos Global ManagementAdded · +1,050,000 sh+$15.2M
- Caption ManagementAdded · +1,031,390 sh+$14.9M
- DRIEHAUS CAPITAL MANAGEMENTAdded · +916,128 sh+$13.3M
Biggest sellers
- RA CAPITAL MANAGEMENT, L.P.Sold out · -2,972,973 sh-$43.0M
- Kynam Capital ManagementSold out · -784,606 sh-$11.4M
- Almitas CapitalTrimmed · -503,442 sh-$7.3M
- Point72 Asset Management, L.P.Trimmed · -356,301 sh-$5.2M
- D. E. ShawTrimmed · -274,625 sh-$4.0M
DSGN 13F holders ranked 1–100 of 137
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | SR ONE CAPITAL MANAGEMENT#1 · 6,526,476 sh | 6,526,476 | $94.4M | 9.09% | 0.0% |
| 2 | Logos Global Management#2 · 3,000,000 sh | 3,000,000 | $43.4M | 1.87% | +53.8% |
| 3 | BAKER BROS. ADVISORS#3 · 2,678,430 sh | 2,678,430 | $38.8M | 0.19% | +3.6% |
| 4 | DRIEHAUS CAPITAL MANAGEMENT#4 · 2,661,115 sh | 2,661,115 | $38.5M | 0.22% | +52.5% |
| 5 | BlackRock#5 · 2,660,024 sh | 2,660,024 | $38.5M | <0.01% | +24.7% |
| 6 | Point72 Asset Management, L.P.#6 · 2,366,453 sh | 2,366,453 | $34.2M | 0.04% | -13.1% |
| 7 | Trails Edge Capital Partners#7 · 2,001,282 sh | 2,001,282 | $29.0M | 4.60% | +134.9% |
| 8 | Frazier Life Sciences Management, L.P.#8 · 1,809,854 sh | 1,809,854 | $26.2M | 0.57% | New |
| 9 | Vivo Capital#9 · 1,612,903 sh | 1,612,903 | $23.3M | 2.13% | 0.0% |
| 10 | VANGUARD CAPITAL MANAGEMENT#10 · 1,571,022 sh | 1,571,022 | $22.7M | <0.01% | +16.4% |
| 11 | Caption Management#11 · 1,118,098 sh | 1,118,098 | $16.2M | 0.08% | +1189.5% |
| 12 | Almitas Capital#12 · 1,026,893 sh | 1,026,893 | $14.9M | 3.56% | -32.9% |
| 13 | GEODE CAPITAL MANAGEMENT#13 · 958,417 sh | 958,417 | $13.9M | <0.01% | +38.4% |
| 14 | Sofinnova Ventures#14 · 865,135 sh | 865,135 | $12.5M | 0.65% | New |
| 15 | FMR#15 · 776,462 sh | 776,462 | $11.2M | <0.01% | -2.7% |
| 16 | MORGAN STANLEY#16 · 765,425 sh | 765,425 | $11.1M | <0.01% | +16.6% |
| 17 | STATE STREET#17 · 736,221 sh | 736,221 | $10.7M | <0.01% | +11.6% |
| 18 | Woodline Partners#18 · 700,354 sh | 700,354 | $10.1M | 0.03% | -27.2% |
| 19 | DIMENSIONAL FUND ADVISORS#19 · 694,743 sh | 694,743 | $10.1M | <0.01% | +60.9% |
| 20 | GOLDMAN SACHS GROUP#20 · 656,584 sh | 656,584 | $9.5M | <0.01% | +30.1% |
| 21 | JACOBS LEVY EQUITY MANAGEMENT#21 · 565,597 sh | 565,597 | $8.2M | 0.03% | +95.4% |
| 22 | ACADIAN ASSET MANAGEMENT#22 · 537,479 sh | 537,479 | $7.8M | <0.01% | -12.8% |
| 23 | Siren, L.L.C.#23 · 523,212 sh | 523,212 | $7.6M | 0.15% | New |
| 24 | Qube Research & Technologies Ltd#24 · 437,079 sh | 437,079 | $6.3M | <0.01% | +1178.6% |
| 25 | RENAISSANCE TECHNOLOGIES#25 · 387,913 sh | 387,913 | $5.6M | <0.01% | -5.0% |
| 26 | KENNEDY CAPITAL MANAGEMENT#26 · 384,036 sh | 384,036 | $5.6M | 0.10% | +41.4% |
| 27 | NORTHERN#27 · 353,197 sh | 353,197 | $5.1M | <0.01% | +17.6% |
| 28 | ALGERT GLOBAL#28 · 296,085 sh | 296,085 | $4.3M | 0.05% | +44.6% |
| 29 | ACUTA CAPITAL PARTNERS#29 · 282,564 sh | 282,564 | $4.1M | 2.85% | +93.7% |
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT#30 · 271,264 sh | 271,264 | $3.9M | <0.01% | +12.3% |
| 31 | VANGUARD PORTFOLIO MANAGEMENT#31 · 251,442 sh | 251,442 | $3.6M | <0.01% | +81.5% |
| 32 | VANGUARD FIDUCIARY#32 · 230,202 sh | 230,202 | $3.3M | <0.01% | +17.7% |
| 33 | PRUDENTIAL FINANCIAL#33 · 224,170 sh | 224,170 | $3.2M | <0.01% | +389.3% |
| 34 | D. E. Shaw#34 · 195,645 sh | 195,645 | $2.8M | <0.01% | -58.4% |
| 35 | Eversept Partners#35 · 190,000 sh | 190,000 | $2.7M | 0.14% | New |
| 36 | KVP Capital Advisors#36 · 185,000 sh | 185,000 | $2.7M | 1.96% | New |
| 37 | J. Goldman#37 · 176,770 sh | 176,770 | $2.6M | 0.07% | New |
| 38 | MILLENNIUM MANAGEMENT#38 · 147,714 sh | 147,714 | $2.1M | <0.01% | +35.6% |
| 39 | RAYMOND JAMES FINANCIAL#39 · 138,521 sh | 138,521 | $2.0M | <0.01% | +27.7% |
| 40 | BALYASNY ASSET MANAGEMENT L.P.#40 · 111,103 sh | 111,103 | $1.6M | <0.01% | New |
| 41 | Elmind Capital#41 · 107,900 sh | 107,900 | $1.6M | 0.39% | -48.1% |
| 42 | Nuveen#42 · 104,734 sh | 104,734 | $1.5M | <0.01% | -17.4% |
| 43 | DAFNA Capital Management#43 · 102,600 sh | 102,600 | $1.5M | 0.28% | New |
| 44 | Bank of New York Mellon#44 · 92,069 sh | 92,069 | $1.3M | <0.01% | +15.6% |
| 45 | China Universal Asset Management , Ltd.#45 · 89,940 sh | 89,940 | $1.3M | 0.08% | +156.2% |
| 46 | CITADEL ADVISORS#46 · 81,971 sh | 81,971 | $1.2M | <0.01% | -64.6% |
| 47 | SummitTX Capital, L.P.#47 · 80,663 sh | 80,663 | $1.2M | 0.03% | New |
| 48 | AMERICAN CENTURY COMPANIES#48 · 76,825 sh | 76,825 | $1.1M | <0.01% | +17.0% |
| 49 | Palumbo Wealth Management#49 · 71,744 sh | 71,744 | $1.0M | 0.22% | +0.5% |
| 50 | AQR CAPITAL MANAGEMENT#50 · 71,114 sh | 71,114 | $1.0M | <0.01% | +174.0% |
| 51 | AMERIPRISE FINANCIAL#51 · 67,598 sh | 67,598 | $978.1K | <0.01% | +93.2% |
| 52 | Russell Investments Group, Ltd.#52 · 66,859 sh | 66,859 | $967.4K | <0.01% | +162.8% |
| 53 | ALPS ADVISORS#53 · 63,391 sh | 63,391 | $917.3K | <0.01% | +26.3% |
| 54 | STATE OF WISCONSIN INVESTMENT BOARD#54 · 59,249 sh | 59,249 | $857.3K | <0.01% | +20.4% |
| 55 | STRS OHIO#55 · 50,500 sh | 50,500 | $730.7K | <0.01% | +13.0% |
| 56 | Verdad Advisers#56 · 47,557 sh | 47,557 | $688.1K | 0.66% | -48.5% |
| 57 | BANK OF AMERICA#57 · 43,728 sh | 43,728 | $632.7K | 0.00% | +88.0% |
| 58 | ExodusPoint Capital Management#58 · 41,286 sh | 41,286 | $597.4K | <0.01% | New |
| 59 | RHUMBLINE ADVISERS#59 · 38,132 sh | 38,132 | $551.8K | <0.01% | +9.4% |
| 60 | Vanguard Global Advisers#60 · 35,534 sh | 35,534 | $514.2K | <0.01% | +200.1% |
| 61 | UBS Group AG#61 · 34,761 sh | 34,761 | $503.0K | <0.01% | +103.4% |
| 62 | Susquehanna Portfolio Strategies#62 · 33,375 sh | 33,375 | $482.9K | <0.01% | New |
| 63 | TWO SIGMA INVESTMENTS#63 · 32,925 sh | 32,925 | $476.4K | <0.01% | +102.0% |
| 64 | CANADA PENSION PLAN INVESTMENT BOARD#64 · 32,600 sh | 32,600 | $471.7K | <0.01% | -46.0% |
| 65 | OPPENHEIMER#65 · 32,087 sh | 32,087 | $464.3K | — | New |
| 66 | ALLIANCEBERNSTEIN L.P.#66 · 43,230 sh | 43,230 | $460.0K | <0.01% | -6.3% |
| 67 | DEUTSCHE BANK AG\#67 · 30,613 sh | 30,613 | $443.0K | <0.01% | +48.3% |
| 68 | Virtus Investment Advisers#68 · 29,827 sh | 29,827 | $431.6K | 0.10% | New |
| 69 | Squarepoint Ops#69 · 29,630 sh | 29,630 | $428.7K | <0.01% | -65.6% |
| 70 | Trexquant Investment#70 · 28,150 sh | 28,150 | $407.3K | <0.01% | -76.0% |
| 71 | WELLS FARGO & COMPANY#71 · 28,072 sh | 28,072 | $406.2K | <0.01% | +211.0% |
| 72 | Corient Private Wealth#72 · 27,169 sh | 27,169 | $393.1K | <0.01% | 0.0% |
| 73 | BRIDGEWAY CAPITAL MANAGEMENT#73 · 27,000 sh | 27,000 | $390.7K | <0.01% | -48.1% |
| 74 | Quantinno Capital Management#74 · 26,901 sh | 26,901 | $389.3K | <0.01% | +90.4% |
| 75 | PRICE T ROWE ASSOCIATES#75 · 25,606 sh | 25,606 | $371.0K | 0.00% | +56.4% |
| 76 | SEI INVESTMENTS#76 · 22,740 sh | 22,740 | $329.1K | <0.01% | -82.9% |
| 77 | XTX Topco Ltd#77 · 22,383 sh | 22,383 | $323.9K | <0.01% | -63.3% |
| 78 | AlphaCentric Advisors#78 · 21,537 sh | 21,537 | $311.6K | 0.26% | +1.4% |
| 79 | Invesco Ltd.#79 · 21,429 sh | 21,429 | $310.1K | 0.00% | -84.9% |
| 80 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO#80 · 20,700 sh | 20,700 | $299.5K | <0.01% | +36.2% |
| 81 | MetLife Investment Management#81 · 20,609 sh | 20,609 | $298.2K | <0.01% | +35.1% |
| 82 | WELLINGTON MANAGEMENT GROUP LLP#82 · 19,400 sh | 19,400 | $280.7K | 0.00% | New |
| 83 | JPMORGAN CHASE#83 · 16,904 sh | 16,904 | $240.7K | 0.00% | +19.6% |
| 84 | CITIGROUP#84 · 15,880 sh | 15,880 | $229.8K | <0.01% | +272.5% |
| 85 | Creative Planning#85 · 15,844 sh | 15,844 | $229.3K | <0.01% | New |
| 86 | SUSQUEHANNA INTERNATIONAL GROUP, LLP#86 · 15,650 sh | 15,650 | $226.5K | 0.00% | New |
| 87 | NISA INVESTMENT ADVISORS#87 · 14,824 sh | 14,824 | $214.5K | — | 0.0% |
| 88 | MIRAE ASSET GLOBAL ETFS Ltd.#88 · 14,171 sh | 14,171 | $205.1K | <0.01% | +24.7% |
| 89 | Y-Intercept (Hong Kong) Ltd#89 · 12,910 sh | 12,910 | $186.8K | — | New |
| 90 | SUSQUEHANNA FUNDAMENTAL INVESTMENTS#90 · 12,553 sh | 12,553 | $181.6K | <0.01% | New |
| 91 | ROYAL BANK OF CANADA#91 · 12,254 sh | 12,254 | $178.0K | 0.00% | +7.8% |
| 92 | BARCLAYS PLC#92 · 11,707 sh | 11,707 | $169.4K | 0.00% | -79.0% |
| 93 | NEW YORK STATE COMMON RETIREMENT FUND#93 · 10,826 sh | 10,826 | $156.7K | <0.01% | +434.4% |
| 94 | CAZ INVESTMENTS#94 · 10,500 sh | 10,500 | $151.9K | 0.01% | +200.0% |
| 95 | GSA CAPITAL PARTNERS LLP#95 · 10,328 sh | 10,328 | $149.0K | <0.01% | New |
| 96 | Police & Firemen's Retirement System of New Jersey#96 · 9,849 sh | 9,849 | $142.5K | <0.01% | +49.3% |
| 97 | BNP PARIBAS FINANCIAL MARKETS#97 · 5,751 sh | 5,751 | $83.2K | 0.00% | -88.6% |
| 98 | Clearstead Advisors#98 · 5,610 sh | 5,610 | $81.2K | <0.01% | +819.7% |
| 99 | Tower Research Capital (TRC)#99 · 4,908 sh | 4,908 | $71.0K | <0.01% | +217.7% |
| 100 | Rockefeller Capital Management L.P.#100 · 3,684 sh | 3,684 | $53.3K | <0.01% | 0.0% |
Funds that sold out of DSGN in Q2 2026 (16)
Held DSGN at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P.2,972,973 sh | 2,972,973 | $31.6M |
| Kynam Capital Management784,606 sh | 784,606 | $8.3M |
| MARSHALL WACE, LLP151,008 sh | 151,008 | $1.6M |
| Lynx1 Capital Management119,516 sh | 119,516 | $1.3M |
| JANE STREET GROUP103,902 sh | 103,902 | $1.1M |
| Informed Momentum78,949 sh | 78,949 | $840.0K |
| Velan Capital Investment Management20,000 sh | 20,000 | $212.8K |
| Engineers Gate Manager16,090 sh | 16,090 | $171.2K |
| Brevan Howard Capital Management15,294 sh | 15,294 | $162.7K |
| Dynamic Technology Lab Private Ltd14,749 sh | 14,749 | $156.9K |
| Mariner13,066 sh | 13,066 | $138.9K |
| Baader Bank Aktiengesellschaft12,792 sh | 12,792 | $136.1K |
| MIRABELLA FINANCIAL SERVICES LLP11,814 sh | 11,814 | $125.7K |
| ADAR1 Capital Management10,000 sh | 10,000 | $106.4K |
| Root Financial Partners38 sh | 38 | $404.00 |
| MAI Capital Management8 sh | 8 | $86.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.