SPRUCE BIOSCIENCES, INC. (SPRB) — Institutional Holders, Q2 2026
65 institutional investment managers reported a SPRB position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $116.3M. Every filer is listed below, ranked by position value. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
SPRB in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- AIGH Capital ManagementNew · +250,000 sh+$13.5M
- ORBIMED ADVISORSNew · +200,000 sh+$10.8M
- BlackRockAdded · +170,898 sh+$9.2M
- VANGUARD CAPITAL MANAGEMENTNew · +119,331 sh+$6.4M
- Cable Car CapitalNew · +60,000 sh+$3.2M
Biggest sellers
- WELLINGTON MANAGEMENT GROUP LLPSold out · -48,796 sh-$2.6M
- BALYASNY ASSET MANAGEMENT L.P.Trimmed · -27,862 sh-$1.5M
- CITADEL ADVISORSTrimmed · -18,094 sh-$977.1K
- Squadron Capital ManagementSold out · -12,200 sh-$658.8K
- Resolute Capital Asset PartnersSold out · -4,000 sh-$216.0K
SPRB 13F holders ranked 1–65 of 65
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | AIGH Capital Management#1 · 250,000 sh | 250,000 | $13.5M | 0.85% | New |
| 2 | ORBIMED ADVISORS#2 · 200,000 sh | 200,000 | $10.8M | 0.20% | New |
| 3 | BlackRock#3 · 187,836 sh | 187,836 | $10.1M | <0.01% | +1009.0% |
| 4 | MILLENNIUM MANAGEMENT#4 · 160,981 sh | 160,981 | $8.7M | <0.01% | +43.9% |
| 5 | AWM Investment Company#5 · 146,988 sh | 146,988 | $7.9M | 0.69% | New |
| 6 | Ikarian Capital#6 · 121,356 sh | 121,356 | $6.6M | 0.71% | 0.0% |
| 7 | VANGUARD CAPITAL MANAGEMENT#7 · 119,331 sh | 119,331 | $6.4M | <0.01% | New |
| 8 | Alyeska Investment Group, L.P.#8 · 81,671 sh | 81,671 | $4.4M | 0.01% | +58.1% |
| 9 | GEODE CAPITAL MANAGEMENT#9 · 70,548 sh | 70,548 | $3.8M | <0.01% | +447.4% |
| 10 | ADAR1 Capital Management#10 · 67,717 sh | 67,717 | $3.7M | 0.17% | +15.6% |
| 11 | Cable Car Capital#11 · 60,000 sh | 60,000 | $3.2M | 0.07% | New |
| 12 | CITADEL ADVISORS#12 · 51,905 sh | 51,905 | $2.8M | <0.01% | -25.8% |
| 13 | STATE STREET#13 · 50,450 sh | 50,450 | $2.7M | <0.01% | +834.3% |
| 14 | BOOTHBAY FUND MANAGEMENT#14 · 42,080 sh | 42,080 | $2.3M | 0.03% | 0.0% |
| 15 | StemPoint Capital#15 · 41,388 sh | 41,388 | $2.2M | 0.39% | +550.8% |
| 16 | Eversept Partners#16 · 40,000 sh | 40,000 | $2.2M | 0.11% | New |
| 17 | Carlyle Group#17 · 38,620 sh | 38,620 | $2.1M | 0.02% | 0.0% |
| 18 | GOLDMAN SACHS GROUP#18 · 32,348 sh | 32,348 | $1.7M | <0.01% | +487.5% |
| 19 | Affinity Asset Advisors#19 · 30,000 sh | 30,000 | $1.6M | 0.07% | New |
| 20 | DIADEMA PARTNERS#20 · 30,000 sh | 30,000 | $1.6M | 0.20% | +200.0% |
| 21 | Stonepine Capital Management#21 · 28,795 sh | 28,795 | $1.6M | 0.73% | New |
| 22 | Point72 Asset Management, L.P.#22 · 28,278 sh | 28,278 | $1.5M | <0.01% | New |
| 23 | Quinn Opportunity Partners#23 · 26,810 sh | 26,810 | $1.4M | 0.07% | 0.0% |
| 24 | UBS Group AG#24 · 23,381 sh | 23,381 | $1.3M | <0.01% | +496.6% |
| 25 | ExodusPoint Capital Management#25 · 22,000 sh | 22,000 | $1.2M | <0.01% | 0.0% |
| 26 | NORTHERN#26 · 21,083 sh | 21,083 | $1.1M | <0.01% | New |
| 27 | Rosalind Advisors#27 · 20,000 sh | 20,000 | $1.1M | 0.28% | New |
| 28 | Knott David M Jr#28 · 20,000 sh | 20,000 | $1.1M | 0.57% | New |
| 29 | AMERIPRISE FINANCIAL#29 · 18,834 sh | 18,834 | $1.0M | <0.01% | New |
| 30 | VANGUARD PORTFOLIO MANAGEMENT#30 · 18,496 sh | 18,496 | $998.8K | 0.00% | New |
| 31 | VANGUARD FIDUCIARY#31 · 18,361 sh | 18,361 | $991.5K | <0.01% | New |
| 32 | BALYASNY ASSET MANAGEMENT L.P.#32 · 12,138 sh | 12,138 | $655.5K | <0.01% | -69.7% |
| 33 | DIMENSIONAL FUND ADVISORS#33 · 8,813 sh | 8,813 | $476.6K | <0.01% | New |
| 34 | Persistent Asset Partners Ltd#34 · 7,677 sh | 7,677 | $414.6K | 0.12% | +203.7% |
| 35 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM#35 · 7,182 sh | 7,182 | $387.8K | <0.01% | New |
| 36 | Bank of New York Mellon#36 · 6,779 sh | 6,779 | $366.1K | <0.01% | New |
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT#37 · 5,896 sh | 5,896 | $318.4K | 0.00% | New |
| 38 | RENAISSANCE TECHNOLOGIES#38 · 4,700 sh | 4,700 | $253.8K | <0.01% | New |
| 39 | MORGAN STANLEY#39 · 4,411 sh | 4,411 | $238.2K | 0.00% | +211.7% |
| 40 | Pale Fire Capital SE#40 · 3,818 sh | 3,818 | $206.2K | 0.01% | New |
| 41 | RHUMBLINE ADVISERS#41 · 3,519 sh | 3,519 | $190.0K | <0.01% | New |
| 42 | SkyView Investment Advisors#42 · 3,000 sh | 3,000 | $162.0K | 0.13% | New |
| 43 | DEUTSCHE BANK AG\#43 · 2,652 sh | 2,652 | $143.2K | 0.00% | New |
| 44 | WELLS FARGO & COMPANY#44 · 2,329 sh | 2,329 | $125.8K | 0.00% | New |
| 45 | NEW YORK STATE COMMON RETIREMENT FUND#45 · 1,900 sh | 1,900 | $102.6K | <0.01% | New |
| 46 | CITIGROUP#46 · 1,265 sh | 1,265 | $68.3K | 0.00% | +34.7% |
| 47 | MIRAE ASSET GLOBAL ETFS Ltd.#47 · 1,252 sh | 1,252 | $67.6K | <0.01% | New |
| 48 | JPMORGAN CHASE#48 · 1,127 sh | 1,127 | $63.0K | 0.00% | New |
| 49 | Lion Point Capital#49 · 1,000 sh | 1,000 | $54.0K | 0.26% | 0.0% |
| 50 | Police & Firemen's Retirement System of New Jersey#50 · 864 sh | 864 | $46.7K | <0.01% | New |
| 51 | BARCLAYS PLC#51 · 674 sh | 674 | $36.4K | 0.00% | New |
| 52 | BNP PARIBAS FINANCIAL MARKETS#52 · 453 sh | 453 | $24.5K | 0.00% | New |
| 53 | Vanguard Global Advisers#53 · 452 sh | 452 | $24.4K | 0.00% | New |
| 54 | FMR#54 · 343 sh | 343 | $18.5K | 0.00% | New |
| 55 | Legal & General Group Plc#55 · 264 sh | 264 | $14.2K | 0.00% | New |
| 56 | Ameritas Investment Partners#56 · 247 sh | 247 | $13.3K | <0.01% | New |
| 57 | Tower Research Capital (TRC)#57 · 246 sh | 246 | $13.3K | <0.01% | +75.7% |
| 58 | Russell Investments Group, Ltd.#58 · 217 sh | 217 | $11.7K | 0.00% | New |
| 59 | SBI Securities , Ltd.#59 · 201 sh | 201 | $10.9K | — | New |
| 60 | ROYAL BANK OF CANADA#60 · 166 sh | 166 | $8.0K | 0.00% | New |
| 61 | Sterling Capital Management#61 · 43 sh | 43 | $2.3K | — | New |
| 62 | JONES FINANCIAL COMPANIES LLLP#62 · 30 sh | 30 | $1.7K | 0.00% | -84.5% |
| 63 | CALDWELL SUTTER CAPITAL#63 · 13 sh | 13 | $702.00 | <0.01% | 0.0% |
| 64 | Friedenthal Financial#64 · 7 sh | 7 | $378.00 | <0.01% | New |
| 65 | Cassaday & Wealth Management#65 · 2 sh | 2 | $108.00 | 0.00% | 0.0% |
Funds that sold out of SPRB in Q2 2026 (4)
Held SPRB at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP48,796 sh | 48,796 | $3.2M |
| Squadron Capital Management12,200 sh | 12,200 | $797.3K |
| Resolute Capital Asset Partners4,000 sh | 4,000 | $261.4K |
| Sound Income Strategies200 sh | 200 | $13.9K |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.