Sionna Therapeutics, Inc. (SION) — Institutional Holders, Q2 2026
147 institutional investment managers reported a SION position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $2.1B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
SION in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- ADAGE CAPITAL PARTNERS GP, L.L.C.Added · +1,450,000 sh+$63.8M
- Casdin CapitalNew · +400,000 sh+$17.6M
- Siren, L.L.C.Added · +310,515 sh+$13.7M
- DRIEHAUS CAPITAL MANAGEMENTAdded · +308,814 sh+$13.6M
- STATE STREETAdded · +265,307 sh+$11.7M
Biggest sellers
- ORBIMED ADVISORSTrimmed · -974,825 sh-$42.9M
- DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)Trimmed · -289,674 sh-$12.7M
- abrdn plcTrimmed · -280,037 sh-$12.3M
- JENNISON ASSOCIATESTrimmed · -279,087 sh-$12.3M
- PRICE T ROWE ASSOCIATESTrimmed · -278,360 sh-$12.2M
SION 13F holders ranked 1–100 of 147
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P.#1 · 9,905,045 sh | 9,905,045 | $435.7M | 3.79% | 0.0% |
| 2 | TPG GP A#2 · 6,494,962 sh | 6,494,962 | $285.7M | 5.71% | 0.0% |
| 3 | VIKING GLOBAL INVESTORS#3 · 3,195,181 sh | 3,195,181 | $140.6M | 0.40% | 0.0% |
| 4 | Atlas Venture Life Science Advisors#4 · 2,995,602 sh | 2,995,602 | $131.8M | 14.95% | 0.0% |
| 5 | ORBIMED ADVISORS#5 · 2,555,877 sh | 2,555,877 | $112.4M | 2.08% | -27.6% |
| 6 | Enavate Sciences GP#6 · 2,478,030 sh | 2,478,030 | $109.0M | 31.56% | 0.0% |
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C.#7 · 1,600,000 sh | 1,600,000 | $70.4M | 0.10% | +966.7% |
| 8 | BlackRock#8 · 1,474,769 sh | 1,474,769 | $64.9M | <0.01% | +13.8% |
| 9 | JPMORGAN CHASE#9 · 1,490,508 sh | 1,490,508 | $64.1M | <0.01% | +1.7% |
| 10 | JENNISON ASSOCIATES#10 · 1,172,133 sh | 1,172,133 | $51.6M | 0.03% | -19.2% |
| 11 | CITADEL ADVISORS#11 · 1,147,636 sh | 1,147,636 | $50.5M | <0.01% | -1.7% |
| 12 | VANGUARD CAPITAL MANAGEMENT#12 · 1,132,001 sh | 1,132,001 | $49.8M | <0.01% | +10.0% |
| 13 | STATE STREET#13 · 1,021,534 sh | 1,021,534 | $44.9M | <0.01% | +35.1% |
| 14 | PERCEPTIVE ADVISORS#14 · 905,000 sh | 905,000 | $39.8M | 0.60% | +37.4% |
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)#15 · 680,916 sh | 680,916 | $30.0M | 0.31% | -29.8% |
| 16 | Siren, L.L.C.#16 · 610,515 sh | 610,515 | $26.9M | 0.54% | +103.5% |
| 17 | PRICE T ROWE ASSOCIATES#17 · 478,016 sh | 478,016 | $21.0M | <0.01% | -36.8% |
| 18 | EVENTIDE ASSET MANAGEMENT#18 · 474,981 sh | 474,981 | $20.9M | 0.28% | -26.4% |
| 19 | GEODE CAPITAL MANAGEMENT#19 · 457,145 sh | 457,145 | $20.1M | <0.01% | +17.3% |
| 20 | BAKER BROS. ADVISORS#20 · 400,000 sh | 400,000 | $17.6M | 0.09% | 0.0% |
| 21 | Casdin Capital#21 · 400,000 sh | 400,000 | $17.6M | 0.88% | New |
| 22 | GOLDMAN SACHS GROUP#22 · 388,810 sh | 388,810 | $17.1M | <0.01% | +47.7% |
| 23 | DRIEHAUS CAPITAL MANAGEMENT#23 · 385,447 sh | 385,447 | $17.0M | 0.10% | +403.0% |
| 24 | FRANKLIN RESOURCES#24 · 290,113 sh | 290,113 | $12.8M | <0.01% | +65.3% |
| 25 | abrdn plc#25 · 284,138 sh | 284,138 | $12.5M | 0.02% | -49.6% |
| 26 | FMR#26 · 278,292 sh | 278,292 | $12.2M | <0.01% | +241.9% |
| 27 | MILLENNIUM MANAGEMENT#27 · 276,733 sh | 276,733 | $12.2M | <0.01% | +96.8% |
| 28 | Candriam S.C.A.#28 · 233,208 sh | 233,208 | $10.2M | 0.05% | -1.5% |
| 29 | VANGUARD PORTFOLIO MANAGEMENT#29 · 222,949 sh | 222,949 | $9.8M | <0.01% | +56.9% |
| 30 | Kalehua Capital Management#30 · 197,072 sh | 197,072 | $8.7M | 6.21% | 0.0% |
| 31 | Longaeva Partners L.P.#31 · 196,352 sh | 196,352 | $8.6M | 0.19% | +1446.9% |
| 32 | Artisan Partners Limited Partnership#32 · 189,498 sh | 189,498 | $8.3M | 0.01% | New |
| 33 | Ensign Peak Advisors#33 · 184,532 sh | 184,532 | $8.1M | 0.01% | -27.8% |
| 34 | Soleus Capital Management, L.P.#34 · 177,687 sh | 177,687 | $7.8M | 0.27% | -39.5% |
| 35 | NORTHERN#35 · 154,476 sh | 154,476 | $6.8M | <0.01% | +32.3% |
| 36 | MORGAN STANLEY#36 · 151,047 sh | 151,047 | $6.6M | <0.01% | +13.5% |
| 37 | Sofinnova Ventures#37 · 144,432 sh | 144,432 | $6.4M | 0.33% | New |
| 38 | Qube Research & Technologies Ltd#38 · 140,309 sh | 140,309 | $6.2M | <0.01% | +232.2% |
| 39 | Alyeska Investment Group, L.P.#39 · 136,222 sh | 136,222 | $6.0M | 0.02% | 0.0% |
| 40 | GordonMD Global Investments#40 · 136,000 sh | 136,000 | $6.0M | 2.89% | 0.0% |
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT#41 · 129,753 sh | 129,753 | $5.7M | <0.01% | +7.9% |
| 42 | Sio Capital Management#42 · 127,808 sh | 127,808 | $5.6M | 0.93% | -56.6% |
| 43 | VANGUARD FIDUCIARY#43 · 121,442 sh | 121,442 | $5.3M | <0.01% | +8.3% |
| 44 | Artia Global Partners#44 · 119,741 sh | 119,741 | $5.3M | 0.97% | 0.0% |
| 45 | UBS Group AG#45 · 116,206 sh | 116,206 | $5.1M | <0.01% | -21.3% |
| 46 | First Turn Management#46 · 110,493 sh | 110,493 | $4.9M | 0.52% | New |
| 47 | CITIGROUP#47 · 110,163 sh | 110,163 | $4.8M | <0.01% | +510.1% |
| 48 | D. E. Shaw#48 · 101,644 sh | 101,644 | $4.5M | <0.01% | New |
| 49 | Rock Springs Capital Management#49 · 99,429 sh | 99,429 | $4.4M | 0.21% | 0.0% |
| 50 | Walleye Capital#50 · 97,347 sh | 97,347 | $4.3M | 0.02% | +544.8% |
| 51 | Rhenman & Partners Asset Management AB#51 · 97,100 sh | 97,100 | $4.3M | 0.40% | +11.0% |
| 52 | BANK OF AMERICA#52 · 88,908 sh | 88,908 | $3.9M | <0.01% | +74.8% |
| 53 | AMERIPRISE FINANCIAL#53 · 82,232 sh | 82,232 | $3.6M | <0.01% | +0.3% |
| 54 | Integral Health Asset Management#54 · 75,000 sh | 75,000 | $3.3M | 0.13% | +50.0% |
| 55 | SUPERSTRING CAPITAL MANAGEMENT#55 · 63,156 sh | 63,156 | $2.8M | 1.75% | -55.2% |
| 56 | StemPoint Capital#56 · 59,426 sh | 59,426 | $2.6M | 0.45% | +62.6% |
| 57 | DEUTSCHE BANK AG\#57 · 53,353 sh | 53,353 | $2.3M | <0.01% | +302.7% |
| 58 | SEVEN GRAND MANAGERS#58 · 50,000 sh | 50,000 | $2.2M | 0.09% | 0.0% |
| 59 | Point72 Asset Management, L.P.#59 · 49,328 sh | 49,328 | $2.2M | <0.01% | -63.9% |
| 60 | TD ASSET MANAGEMENT#60 · 47,396 sh | 47,396 | $2.1M | <0.01% | -42.9% |
| 61 | ALPS ADVISORS#61 · 45,525 sh | 45,525 | $2.0M | <0.01% | +24.3% |
| 62 | SILVERARC CAPITAL MANAGEMENT#62 · 42,478 sh | 42,478 | $1.9M | 0.19% | +7.8% |
| 63 | Russell Investments Group, Ltd.#63 · 42,258 sh | 42,258 | $1.9M | <0.01% | -12.7% |
| 64 | Bank of New York Mellon#64 · 41,586 sh | 41,586 | $1.8M | <0.01% | +23.1% |
| 65 | Nuveen#65 · 41,259 sh | 41,259 | $1.8M | <0.01% | +73.8% |
| 66 | XTX Topco Ltd#66 · 38,096 sh | 38,096 | $1.7M | 0.02% | +61.8% |
| 67 | WELLINGTON MANAGEMENT GROUP LLP#67 · 37,365 sh | 37,365 | $1.6M | <0.01% | -18.9% |
| 68 | MUTUAL OF AMERICA CAPITAL MANAGEMENT#68 · 35,968 sh | 35,968 | $1.6M | — | New |
| 69 | MANUFACTURERS LIFE INSURANCE COMPANY, THE#69 · 35,420 sh | 35,420 | $1.6M | <0.01% | -45.0% |
| 70 | BNP PARIBAS FINANCIAL MARKETS#70 · 31,803 sh | 31,803 | $1.4M | <0.01% | -21.6% |
| 71 | Ishara Investments#71 · 123,000 sh | 123,000 | $1.4M | 0.99% | +150.0% |
| 72 | Swiss National Bank#72 · 27,000 sh | 27,000 | $1.2M | <0.01% | New |
| 73 | Quadrature Capital Ltd#73 · 26,023 sh | 26,023 | $1.1M | <0.01% | New |
| 74 | Trexquant Investment#74 · 23,810 sh | 23,810 | $1.0M | <0.01% | New |
| 75 | NEW YORK STATE COMMON RETIREMENT FUND#75 · 23,586 sh | 23,586 | $1.0M | <0.01% | +345.0% |
| 76 | ALLIANCEBERNSTEIN L.P.#76 · 25,450 sh | 25,450 | $1.0M | <0.01% | +55.1% |
| 77 | TUDOR INVESTMENT ET AL#77 · 22,575 sh | 22,575 | $993.1K | <0.01% | New |
| 78 | RHUMBLINE ADVISERS#78 · 22,309 sh | 22,309 | $981.4K | <0.01% | +21.9% |
| 79 | Maven Securities LTD#79 · 20,000 sh | 20,000 | $879.8K | 0.02% | -20.0% |
| 80 | LOS ANGELES CAPITAL MANAGEMENT#80 · 18,645 sh | 18,645 | $820.2K | <0.01% | +353.0% |
| 81 | Susquehanna Portfolio Strategies#81 · 18,034 sh | 18,034 | $793.3K | 0.01% | New |
| 82 | Rafferty Asset Management#82 · 18,004 sh | 18,004 | $792.0K | <0.01% | -18.7% |
| 83 | Shay Capital#83 · 18,000 sh | 18,000 | $791.8K | 0.05% | New |
| 84 | WELLS FARGO & COMPANY#84 · 16,821 sh | 16,821 | $740.0K | <0.01% | +185.4% |
| 85 | Engineers Gate Manager#85 · 15,603 sh | 15,603 | $686.4K | <0.01% | New |
| 86 | KENNEDY CAPITAL MANAGEMENT#86 · 12,621 sh | 12,621 | $555.2K | <0.01% | +2.7% |
| 87 | MARSHALL WACE, LLP#87 · 12,599 sh | 12,599 | $554.2K | <0.01% | New |
| 88 | Invesco Ltd.#88 · 12,418 sh | 12,418 | $546.3K | 0.00% | +15.1% |
| 89 | MetLife Investment Management#89 · 10,972 sh | 10,972 | $482.7K | <0.01% | +28.1% |
| 90 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#90 · 10,622 sh | 10,622 | $467.3K | <0.01% | +9056.9% |
| 91 | MIRAE ASSET GLOBAL ETFS Ltd.#91 · 10,582 sh | 10,582 | $463.4K | <0.01% | +15.2% |
| 92 | Jump Financial#92 · 10,473 sh | 10,473 | $460.7K | <0.01% | New |
| 93 | VANGUARD ASSET MANAGEMENT, Ltd#93 · 9,535 sh | 9,535 | $419.4K | <0.01% | New |
| 94 | PROFUND ADVISORS#94 · 9,140 sh | 9,140 | $402.1K | 0.01% | -8.0% |
| 95 | Virtus Investment Advisers#95 · 9,109 sh | 9,109 | $400.7K | 0.09% | +42.9% |
| 96 | Legal & General Group Plc#96 · 9,044 sh | 9,044 | $397.8K | <0.01% | +531.6% |
| 97 | Vanguard Global Advisers#97 · 7,852 sh | 7,852 | $345.4K | <0.01% | -29.8% |
| 98 | China Universal Asset Management , Ltd.#98 · 7,186 sh | 7,186 | $316.1K | 0.02% | -9.3% |
| 99 | Quarry#99 · 6,750 sh | 6,750 | $296.9K | 0.02% | +7.1% |
| 100 | BARCLAYS PLC#100 · 6,495 sh | 6,495 | $285.7K | <0.01% | -64.7% |
Funds that sold out of SION in Q2 2026 (9)
Held SION at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| POLEN CAPITAL MANAGEMENT26,775 sh | 26,775 | $1.1M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP7,310 sh | 7,310 | $293.1K |
| ExodusPoint Capital Management7,190 sh | 7,190 | $288.2K |
| Hudson Bay Capital Management6,180 sh | 6,180 | $247.8K |
| TWO SIGMA INVESTMENTS5,500 sh | 5,500 | $220.5K |
| Cygnus Capital Advisors3,800 sh | 3,800 | $152.0K |
| SIGNATUREFD24 sh | 24 | $962.00 |
| Root Financial Partners10 sh | 10 | $401.00 |
| MAI Capital Management2 sh | 2 | $81.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.