Pyxis Oncology, Inc. (PYXS) — Institutional Holders, Q2 2026
76 institutional investment managers reported a PYXS position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $101.1M. Every filer is listed below, ranked by position value. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
PYXS in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- GordonMD Global InvestmentsAdded · +5,903,039 sh+$17.8M
- Woodline PartnersNew · +523,999 sh+$1.6M
- MARSHALL WACE, LLPAdded · +476,127 sh+$1.4M
- BlackRockAdded · +79,095 sh+$238.1K
- BANK OF AMERICAAdded · +63,657 sh+$191.6K
Biggest sellers
- 683 Capital ManagementTrimmed · -436,896 sh-$1.3M
- MILLENNIUM MANAGEMENTTrimmed · -164,621 sh-$495.5K
- Longaeva Partners L.P.Trimmed · -149,632 sh-$450.4K
- Palo Alto InvestorsTrimmed · -146,233 sh-$440.2K
- RENAISSANCE TECHNOLOGIESTrimmed · -116,448 sh-$350.5K
PYXS 13F holders ranked 1–76 of 76
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | GordonMD Global Investments#1 · 10,024,909 sh | 10,024,909 | $30.2M | 14.60% | +143.2% |
| 2 | PFIZER#2 · 7,032,770 sh | 7,032,770 | $19.5M | 11.43% | 0.0% |
| 3 | Laurion Capital Management#3 · 4,900,888 sh | 4,900,888 | $14.8M | 0.38% | -1.9% |
| 4 | VANGUARD CAPITAL MANAGEMENT#4 · 2,075,997 sh | 2,075,997 | $6.2M | <0.01% | +2.1% |
| 5 | HealthInvest Partners AB#5 · 966,459 sh | 966,459 | $2.9M | 0.78% | +390.5% |
| 6 | BlackRock#6 · 867,934 sh | 867,934 | $2.6M | 0.00% | +10.0% |
| 7 | Palo Alto Investors#7 · 864,277 sh | 864,277 | $2.6M | 0.36% | -14.5% |
| 8 | MARSHALL WACE, LLP#8 · 830,544 sh | 830,544 | $2.5M | <0.01% | +134.3% |
| 9 | RENAISSANCE TECHNOLOGIES#9 · 772,232 sh | 772,232 | $2.3M | <0.01% | -13.1% |
| 10 | GEODE CAPITAL MANAGEMENT#10 · 591,849 sh | 591,849 | $1.8M | <0.01% | -1.0% |
| 11 | Woodline Partners#11 · 523,999 sh | 523,999 | $1.6M | <0.01% | New |
| 12 | 683 Capital Management#12 · 459,367 sh | 459,367 | $1.4M | 0.07% | -48.7% |
| 13 | JACOBS LEVY EQUITY MANAGEMENT#13 · 428,606 sh | 428,606 | $1.3M | <0.01% | -7.0% |
| 14 | Longaeva Partners L.P.#14 · 353,582 sh | 353,582 | $1.1M | 0.02% | -29.7% |
| 15 | Decheng Capital#15 · 326,810 sh | 326,810 | $983.7K | 0.13% | 0.0% |
| 16 | VANGUARD FIDUCIARY#16 · 302,986 sh | 302,986 | $912.0K | <0.01% | +0.7% |
| 17 | JANE STREET GROUP#17 · 290,090 sh | 290,090 | $873.2K | <0.01% | -4.7% |
| 18 | STATE STREET#18 · 248,837 sh | 248,837 | $749.0K | 0.00% | 0.0% |
| 19 | MILLENNIUM MANAGEMENT#19 · 233,004 sh | 233,004 | $701.3K | <0.01% | -41.4% |
| 20 | UBS Group AG#20 · 155,217 sh | 155,217 | $467.2K | <0.01% | -38.9% |
| 21 | Bank of New York Mellon#21 · 133,996 sh | 133,996 | $403.3K | <0.01% | 0.0% |
| 22 | ACADIAN ASSET MANAGEMENT#22 · 126,793 sh | 126,793 | $380.0K | <0.01% | -12.1% |
| 23 | NORTHERN#23 · 123,959 sh | 123,959 | $373.1K | 0.00% | +21.6% |
| 24 | NewEdge Wealth#24 · 116,006 sh | 116,006 | $349.2K | <0.01% | 0.0% |
| 25 | XTX Topco Ltd#25 · 110,939 sh | 110,939 | $333.9K | <0.01% | -44.6% |
| 26 | TWO SIGMA INVESTMENTS#26 · 83,961 sh | 83,961 | $252.7K | <0.01% | +14.5% |
| 27 | BRIDGEWAY CAPITAL MANAGEMENT#27 · 81,260 sh | 81,260 | $244.6K | <0.01% | 0.0% |
| 28 | BANK OF AMERICA#28 · 80,464 sh | 80,464 | $242.2K | 0.00% | +378.8% |
| 29 | STIFEL FINANCIAL#29 · 70,437 sh | 70,437 | $212.0K | <0.01% | +39.4% |
| 30 | Cable Car Capital#30 · 61,606 sh | 61,606 | $185.4K | <0.01% | 0.0% |
| 31 | MYDA Advisors#31 · 50,000 sh | 50,000 | $150.5K | 0.02% | New |
| 32 | Qube Research & Technologies Ltd#32 · 49,932 sh | 49,932 | $150.3K | <0.01% | +342.4% |
| 33 | UNIVERSITY OF CHICAGO#33 · 48,731 sh | 48,731 | $146.7K | 0.03% | 0.0% |
| 34 | CITADEL ADVISORS#34 · 47,317 sh | 47,317 | $142.4K | 0.00% | -22.7% |
| 35 | Quadrature Capital Ltd#35 · 47,067 sh | 47,067 | $141.7K | <0.01% | New |
| 36 | GOLDMAN SACHS GROUP#36 · 45,900 sh | 45,900 | $138.2K | 0.00% | -2.2% |
| 37 | Verdad Advisers#37 · 44,899 sh | 44,899 | $135.1K | 0.13% | New |
| 38 | LPL Financial#38 · 43,554 sh | 43,554 | $131.1K | 0.00% | +29.8% |
| 39 | COMMONWEALTH EQUITY SERVICES#39 · 42,455 sh | 42,455 | $127.8K | <0.01% | +22.2% |
| 40 | J. Derek Lewis & Associates#40 · 42,000 sh | 42,000 | $126.4K | 0.02% | -20.8% |
| 41 | CITIGROUP#41 · 38,205 sh | 38,205 | $115.0K | 0.00% | +2095.7% |
| 42 | SIMPLEX TRADING#42 · 37,902 sh | 37,902 | $114.1K | <0.01% | New |
| 43 | Point72 Asset Management, L.P.#43 · 37,092 sh | 37,092 | $111.6K | <0.01% | +15.9% |
| 44 | Walleye Capital#44 · 36,778 sh | 36,778 | $110.7K | <0.01% | New |
| 45 | DIMENSIONAL FUND ADVISORS#45 · 36,175 sh | 36,175 | $108.9K | 0.00% | +39.6% |
| 46 | MORGAN STANLEY#46 · 33,448 sh | 33,448 | $100.7K | 0.00% | -52.0% |
| 47 | MACKENZIE FINANCIAL#47 · 26,343 sh | 26,343 | $79.3K | <0.01% | New |
| 48 | Cetera Investment Advisers#48 · 25,000 sh | 25,000 | $75.3K | <0.01% | -8.3% |
| 49 | Graham Capital Management, L.P.#49 · 22,708 sh | 22,708 | $68.4K | <0.01% | -0.2% |
| 50 | Vanguard Global Advisers#50 · 21,242 sh | 21,242 | $63.9K | 0.00% | 0.0% |
| 51 | OSAIC#51 · 17,721 sh | 17,721 | $53.3K | <0.01% | +29.2% |
| 52 | GROUP ONE TRADING, L.P.#52 · 16,480 sh | 16,480 | $49.6K | <0.01% | New |
| 53 | FMR#53 · 12,383 sh | 12,383 | $37.3K | 0.00% | +4.0% |
| 54 | PACES FERRY WEALTH ADVISORS#54 · 11,440 sh | 11,440 | $34.4K | 0.01% | 0.0% |
| 55 | NewEdge Advisors#55 · 10,250 sh | 10,250 | $30.9K | <0.01% | New |
| 56 | China Universal Asset Management , Ltd.#56 · 10,083 sh | 10,083 | $30.4K | <0.01% | -8.7% |
| 57 | Tower Research Capital (TRC)#57 · 9,398 sh | 9,398 | $28.3K | <0.01% | -9.0% |
| 58 | PNC FINANCIAL SERVICES GROUP#58 · 6,500 sh | 6,500 | $19.6K | 0.00% | 0.0% |
| 59 | Winthrop Capital Management#59 · 6,000 sh | 6,000 | $18.0K | <0.01% | 0.0% |
| 60 | JPMORGAN CHASE#60 · 5,545 sh | 5,545 | $15.9K | 0.00% | +7.2% |
| 61 | HAGER INVESTMENT MANAGEMENT SERVICES#61 · 5,000 sh | 5,000 | $15.1K | <0.01% | 0.0% |
| 62 | BARCLAYS PLC#62 · 4,669 sh | 4,669 | $14.1K | 0.00% | -90.6% |
| 63 | Federation des caisses Desjardins du Quebec#63 · 4,500 sh | 4,500 | $13.5K | 0.00% | New |
| 64 | FEDERATED HERMES#64 · 2,962 sh | 2,962 | $8.9K | 0.00% | -6.9% |
| 65 | Mirae Asset Global Investments , Ltd.#65 · 2,833 sh | 2,833 | $8.5K | 0.00% | -12.8% |
| 66 | BNP PARIBAS FINANCIAL MARKETS#66 · 2,689 sh | 2,689 | $8.1K | 0.00% | +62.6% |
| 67 | FIRST UNITED BANK#67 · 2,500 sh | 2,500 | $7.4K | — | New |
| 68 | GF FUND MANAGEMENT LTD.#68 · 1,226 sh | 1,226 | $3.7K | — | -6.8% |
| 69 | NISA INVESTMENT ADVISORS#69 · 961 sh | 961 | $2.9K | — | 0.0% |
| 70 | Physician Wealth Advisors#70 · 943 sh | 943 | $2.8K | — | 0.0% |
| 71 | SBI Securities , Ltd.#71 · 509 sh | 509 | $1.5K | — | New |
| 72 | JONES FINANCIAL COMPANIES LLLP#72 · 500 sh | 500 | $1.4K | 0.00% | 0.0% |
| 73 | WELLS FARGO & COMPANY#73 · 285 sh | 285 | $858.00 | 0.00% | 0.0% |
| 74 | Cornerstone Financial Management#74 · 172 sh | 172 | $518.00 | <0.01% | 0.0% |
| 75 | Caitong International Asset Management , Ltd#75 · 35 sh | 35 | $105.00 | 0.00% | +775.0% |
| 76 | SRS Capital Advisors#76 · 14 sh | 14 | $42.00 | 0.00% | +1300.0% |
Funds that sold out of PYXS in Q2 2026 (10)
Held PYXS at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| PANAGORA ASSET MANAGEMENT69,424 sh | 69,424 | $101.4K |
| TORONTO DOMINION BANK50,000 sh | 50,000 | $73.0K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP41,201 sh | 41,201 | $60.2K |
| Maia Wealth21,277 sh | 21,277 | $31.1K |
| Catalyst Funds Management Pty Ltd20,400 sh | 20,400 | $29.8K |
| Squarepoint Ops17,537 sh | 17,537 | $25.6K |
| TWO SIGMA SECURITIES13,474 sh | 13,474 | $19.7K |
| ROYAL BANK OF CANADA5,839 sh | 5,839 | $9.0K |
| BALYASNY ASSET MANAGEMENT L.P.743 sh | 743 | $1.1K |
| Golden State Equity Partners10 sh | 10 | $14.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.