Prime Medicine, Inc. (PRME) — Institutional Holders, Q2 2026
188 institutional investment managers reported a PRME position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $392.9M. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
PRME in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- GOLDMAN SACHS GROUPAdded · +2,460,093 sh+$9.1M
- ARK Investment ManagementAdded · +2,101,919 sh+$7.8M
- CITADEL ADVISORSAdded · +1,718,185 sh+$6.3M
- Jump FinancialNew · +1,240,429 sh+$4.6M
- STATE STREETAdded · +1,231,335 sh+$4.5M
Biggest sellers
- D. E. ShawTrimmed · -744,681 sh-$2.7M
- RENAISSANCE TECHNOLOGIESTrimmed · -623,627 sh-$2.3M
- Nikko Asset Management AmericasTrimmed · -533,775 sh-$2.0M
- Sumitomo MitsuiTrimmed · -527,809 sh-$1.9M
- HRT FINANCIALTrimmed · -451,259 sh-$1.7M
PRME 13F holders ranked 1–100 of 188
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | Alphabet#1 · 16,562,498 sh | 16,562,498 | $61.1M | 0.06% | 0.0% |
| 2 | BlackRock#2 · 9,602,041 sh | 9,602,041 | $35.4M | <0.01% | +12.9% |
| 3 | ARK Investment Management#3 · 8,348,746 sh | 8,348,746 | $30.8M | 0.20% | +33.6% |
| 4 | STATE STREET#4 · 7,576,460 sh | 7,576,460 | $28.0M | <0.01% | +19.4% |
| 5 | T. Rowe Price Investment Management#5 · 5,237,332 sh | 5,237,332 | $19.3M | 0.01% | -4.5% |
| 6 | VANGUARD CAPITAL MANAGEMENT#6 · 4,522,640 sh | 4,522,640 | $16.7M | <0.01% | +1.1% |
| 7 | BALYASNY ASSET MANAGEMENT L.P.#7 · 3,969,082 sh | 3,969,082 | $14.6M | 0.02% | -3.7% |
| 8 | GOLDMAN SACHS GROUP#8 · 3,430,518 sh | 3,430,518 | $12.7M | <0.01% | +253.5% |
| 9 | Casdin Capital#9 · 3,167,175 sh | 3,167,175 | $11.7M | 0.58% | 0.0% |
| 10 | Woodline Partners#10 · 3,003,904 sh | 3,003,904 | $11.1M | 0.03% | 0.0% |
| 11 | UBS Group AG#11 · 2,794,689 sh | 2,794,689 | $10.3M | <0.01% | -3.2% |
| 12 | GEODE CAPITAL MANAGEMENT#12 · 2,712,446 sh | 2,712,446 | $10.0M | <0.01% | -1.1% |
| 13 | Sumitomo Mitsui#13 · 2,412,984 sh | 2,412,984 | $8.9M | <0.01% | -17.9% |
| 14 | Nikko Asset Management Americas#14 · 2,407,018 sh | 2,407,018 | $8.9M | 0.11% | -18.2% |
| 15 | CITADEL ADVISORS#15 · 2,054,543 sh | 2,054,543 | $7.6M | <0.01% | +510.8% |
| 16 | ADAR1 Capital Management#16 · 1,997,552 sh | 1,997,552 | $7.4M | 0.34% | +1.2% |
| 17 | FMR#17 · 1,761,884 sh | 1,761,884 | $6.5M | <0.01% | -0.4% |
| 18 | TWO SIGMA INVESTMENTS#18 · 1,524,511 sh | 1,524,511 | $5.6M | <0.01% | -3.1% |
| 19 | Redmile Group#19 · 1,389,632 sh | 1,389,632 | $5.1M | 0.34% | -12.6% |
| 20 | FARALLON CAPITAL MANAGEMENT#20 · 1,240,843 sh | 1,240,843 | $4.6M | 0.02% | 0.0% |
| 21 | Jump Financial#21 · 1,240,429 sh | 1,240,429 | $4.6M | 0.04% | New |
| 22 | BANK OF AMERICA#22 · 981,335 sh | 981,335 | $3.6M | <0.01% | +70.1% |
| 23 | VANGUARD PORTFOLIO MANAGEMENT#23 · 961,826 sh | 961,826 | $3.5M | <0.01% | +11.6% |
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT#24 · 927,538 sh | 927,538 | $3.4M | <0.01% | +1.1% |
| 25 | NORTHERN#25 · 912,597 sh | 912,597 | $3.4M | <0.01% | +2.9% |
| 26 | JPMORGAN CHASE#26 · 810,095 sh | 810,095 | $3.0M | <0.01% | -4.0% |
| 27 | Greenwich Wealth Management#27 · 768,001 sh | 768,001 | $2.8M | 0.10% | +2.4% |
| 28 | VANGUARD FIDUCIARY#28 · 764,633 sh | 764,633 | $2.8M | <0.01% | +6.6% |
| 29 | MORGAN STANLEY#29 · 708,963 sh | 708,963 | $2.6M | <0.01% | +10.9% |
| 30 | Alessandra Capital Management#30 · 666,603 sh | 666,603 | $2.5M | 1.74% | +56.7% |
| 31 | D. E. Shaw#31 · 648,940 sh | 648,940 | $2.4M | <0.01% | -53.4% |
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP#32 · 648,479 sh | 648,479 | $2.4M | <0.01% | -9.4% |
| 33 | Point72 Asset Management, L.P.#33 · 533,553 sh | 533,553 | $2.0M | <0.01% | New |
| 34 | MOORE CAPITAL MANAGEMENT#34 · 500,000 sh | 500,000 | $1.8M | 0.03% | 0.0% |
| 35 | CHELSEA COUNSEL#35 · 449,060 sh | 449,060 | $1.7M | 0.70% | +97.8% |
| 36 | MILLENNIUM MANAGEMENT#36 · 427,097 sh | 427,097 | $1.6M | <0.01% | New |
| 37 | HighTower Advisors#37 · 340,365 sh | 340,365 | $1.3M | <0.01% | 0.0% |
| 38 | DIMENSIONAL FUND ADVISORS#38 · 304,678 sh | 304,678 | $1.1M | <0.01% | +0.1% |
| 39 | WELLINGTON MANAGEMENT GROUP LLP#39 · 304,444 sh | 304,444 | $1.1M | <0.01% | +9.5% |
| 40 | Nuveen#40 · 275,931 sh | 275,931 | $1.0M | <0.01% | 0.0% |
| 41 | WELLS FARGO & COMPANY#41 · 251,747 sh | 251,747 | $928.9K | <0.01% | -21.2% |
| 42 | Bank of New York Mellon#42 · 246,344 sh | 246,344 | $909.0K | <0.01% | -7.8% |
| 43 | IQ EQ FUND MANAGEMENT (IRELAND) Ltd#43 · 225,799 sh | 225,799 | $833.2K | 0.05% | +9.9% |
| 44 | MARSHALL WACE, LLP#44 · 216,841 sh | 216,841 | $800.1K | <0.01% | +52.8% |
| 45 | XTX Topco Ltd#45 · 215,708 sh | 215,708 | $796.0K | 0.01% | +37.1% |
| 46 | Jain Global#46 · 215,218 sh | 215,218 | $794.2K | <0.01% | New |
| 47 | JUPITER ASSET MANAGEMENT LTD#47 · 209,490 sh | 209,490 | $773.0K | <0.01% | New |
| 48 | Swiss National Bank#48 · 208,300 sh | 208,300 | $768.6K | <0.01% | +16.6% |
| 49 | PEAK6#49 · 208,057 sh | 208,057 | $767.7K | <0.01% | New |
| 50 | CITIGROUP#50 · 195,664 sh | 195,664 | $722.0K | <0.01% | +314.3% |
| 51 | Green Alpha Advisors#51 · 185,023 sh | 185,023 | $682.7K | — | -3.2% |
| 52 | Keystone Financial Group#52 · 166,510 sh | 166,510 | $614.4K | 0.04% | +0.3% |
| 53 | MIRAE ASSET GLOBAL ETFS Ltd.#53 · 162,338 sh | 162,338 | $599.5K | <0.01% | +32.6% |
| 54 | PRICE T ROWE ASSOCIATES#54 · 162,325 sh | 162,325 | $599.0K | <0.01% | +21.4% |
| 55 | HRT FINANCIAL#55 · 161,510 sh | 161,510 | $595.0K | <0.01% | -73.6% |
| 56 | Bollard Group#56 · 151,136 sh | 151,136 | $558.0K | 0.02% | -58.1% |
| 57 | Rafferty Asset Management#57 · 145,275 sh | 145,275 | $536.1K | <0.01% | -32.6% |
| 58 | ALLIANCEBERNSTEIN L.P.#58 · 150,300 sh | 150,300 | $523.0K | <0.01% | +22.7% |
| 59 | Invesco Ltd.#59 · 140,308 sh | 140,308 | $517.7K | 0.00% | +44.8% |
| 60 | Concurrent Investment Advisors#60 · 131,722 sh | 131,722 | $486.1K | — | +77.6% |
| 61 | ExodusPoint Capital Management#61 · 118,464 sh | 118,464 | $437.1K | <0.01% | New |
| 62 | AQR CAPITAL MANAGEMENT#62 · 117,998 sh | 117,998 | $435.4K | <0.01% | -78.7% |
| 63 | Virtus Investment Advisers#63 · 117,909 sh | 117,909 | $435.1K | 0.10% | +77.3% |
| 64 | RENAISSANCE TECHNOLOGIES#64 · 117,412 sh | 117,412 | $433.3K | <0.01% | -84.2% |
| 65 | RHUMBLINE ADVISERS#65 · 116,754 sh | 116,754 | $430.8K | <0.01% | +2.2% |
| 66 | FIL Ltd#66 · 115,206 sh | 115,206 | $425.1K | <0.01% | 0.0% |
| 67 | DEUTSCHE BANK AG\#67 · 114,472 sh | 114,472 | $422.4K | <0.01% | -27.3% |
| 68 | Steward Partners Investment Advisory#68 · 108,290 sh | 108,290 | $399.6K | <0.01% | -7.8% |
| 69 | Palumbo Wealth Management#69 · 103,801 sh | 103,801 | $383.0K | 0.08% | +1.5% |
| 70 | MILESTONE ASSET MANAGEMENT#70 · 100,035 sh | 100,035 | $369.1K | — | New |
| 71 | TD ASSET MANAGEMENT#71 · 94,148 sh | 94,148 | $347.4K | <0.01% | 0.0% |
| 72 | LPL Financial#72 · 92,174 sh | 92,174 | $340.1K | <0.01% | +38.8% |
| 73 | Rockefeller Capital Management L.P.#73 · 90,735 sh | 90,735 | $334.8K | <0.01% | -0.7% |
| 74 | BARCLAYS PLC#74 · 88,058 sh | 88,058 | $324.9K | <0.01% | +38.1% |
| 75 | Squarepoint Ops#75 · 88,029 sh | 88,029 | $324.8K | <0.01% | -6.4% |
| 76 | COMMONWEALTH EQUITY SERVICES#76 · 87,310 sh | 87,310 | $322.2K | <0.01% | +431.2% |
| 77 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#77 · 85,300 sh | 85,300 | $314.8K | <0.01% | 0.0% |
| 78 | LOS ANGELES CAPITAL MANAGEMENT#78 · 82,305 sh | 82,305 | $303.7K | <0.01% | +56.4% |
| 79 | PROFUND ADVISORS#79 · 72,624 sh | 72,624 | $268.0K | <0.01% | -24.2% |
| 80 | Legal & General Group Plc#80 · 66,444 sh | 66,444 | $245.2K | <0.01% | 0.0% |
| 81 | BNP PARIBAS FINANCIAL MARKETS#81 · 66,101 sh | 66,101 | $243.9K | <0.01% | +92.1% |
| 82 | BRIDGEWAY CAPITAL MANAGEMENT#82 · 64,800 sh | 64,800 | $239.1K | <0.01% | -51.9% |
| 83 | Jupiter Topco#83 · 60,900 sh | 60,900 | $224.4K | <0.01% | — |
| 84 | Engineers Gate Manager#84 · 59,133 sh | 59,133 | $218.2K | <0.01% | -46.4% |
| 85 | VANGUARD ASSET MANAGEMENT, Ltd#85 · 59,021 sh | 59,021 | $217.8K | <0.01% | 0.0% |
| 86 | SG Americas Securities#86 · 58,922 sh | 58,922 | $217.0K | <0.01% | New |
| 87 | WILEY BROS.-AINTREE CAPITAL#87 · 57,460 sh | 57,460 | $210.6K | <0.01% | -3.4% |
| 88 | MetLife Investment Management#88 · 56,192 sh | 56,192 | $207.3K | <0.01% | +27.1% |
| 89 | Russell Investments Group, Ltd.#89 · 50,994 sh | 50,994 | $188.2K | <0.01% | -20.7% |
| 90 | AMERIPRISE FINANCIAL#90 · 49,941 sh | 49,941 | $184.3K | 0.00% | +0.7% |
| 91 | Mutual Advisors#91 · 45,000 sh | 45,000 | $166.1K | <0.01% | -0.4% |
| 92 | Vanguard Global Advisers#92 · 44,269 sh | 44,269 | $163.4K | <0.01% | 0.0% |
| 93 | Quadrature Capital Ltd#93 · 43,663 sh | 43,663 | $161.1K | <0.01% | -6.9% |
| 94 | IvyRock Asset Management (HK) Ltd#94 · 41,800 sh | 41,800 | $154.2K | 0.09% | 0.0% |
| 95 | Corient Private Wealth#95 · 39,078 sh | 39,078 | $144.2K | <0.01% | -5.2% |
| 96 | JONES FINANCIAL COMPANIES LLLP#96 · 40,867 sh | 40,867 | $140.2K | <0.01% | +1.4% |
| 97 | State of New Jersey Common Pension Fund D#97 · 33,569 sh | 33,569 | $123.9K | <0.01% | +8.8% |
| 98 | Crestwood Advisors Group#98 · 32,041 sh | 32,041 | $118.2K | <0.01% | -1.0% |
| 99 | Police & Firemen's Retirement System of New Jersey#99 · 30,751 sh | 30,751 | $113.5K | <0.01% | 0.0% |
| 100 | OPPENHEIMER#100 · 29,650 sh | 29,650 | $109.4K | — | -11.9% |
Funds that sold out of PRME in Q2 2026 (23)
Held PRME at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| Elevate Capital Advisors151,069 sh | 151,069 | $525.7K |
| TUDOR INVESTMENT ET AL61,546 sh | 61,546 | $214.2K |
| Aquatic Capital Management54,230 sh | 54,230 | $188.7K |
| VARCOV41,964 sh | 41,964 | $146.0K |
| AXQ CAPITAL36,742 sh | 36,742 | $127.9K |
| TRANSCEND WEALTH COLLECTIVE30,070 sh | 30,070 | $104.6K |
| Turtle Creek Wealth Advisors25,000 sh | 25,000 | $87.0K |
| NOMURA24,823 sh | 24,823 | $86.4K |
| GROUP ONE TRADING, L.P.24,766 sh | 24,766 | $86.2K |
| Scientech Research17,931 sh | 17,931 | $62.4K |
| MARTINGALE ASSET MANAGEMENT L P14,848 sh | 14,848 | $51.7K |
| Sterling Investment Advisors, Ltd.13,400 sh | 13,400 | $46.6K |
| MERCER GLOBAL ADVISORS12,305 sh | 12,305 | $42.8K |
| Polymer Capital Management (US)10,317 sh | 10,317 | $35.9K |
| MTM Investment Management3,090 sh | 3,090 | $10.8K |
| Scarborough Advisors1,258 sh | 1,258 | $4.4K |
| MAI Capital Management386 sh | 386 | $1.3K |
| Vanguard National334 sh | 334 | $1.2K |
| True Wealth Design152 sh | 152 | $529.00 |
| Keating Financial Advisory Services59 sh | 59 | $205.00 |
| US BANCORP \DE\33 sh | 33 | $115.00 |
| SJS Investment Consulting10 sh | 10 | $35.00 |
| TWIN PEAKS WEALTH ADVISORS3 sh | 3 | $10.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.