AGIOS PHARMACEUTICALS, INC. (AGIO) — Institutional Holders, Q2 2026
239 institutional investment managers reported a AGIO position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $2.5B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
AGIO in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- ADAR1 Capital ManagementAdded · +1,147,381 sh+$42.6M
- UBS Group AGAdded · +853,291 sh+$31.7M
- Lynx1 Capital ManagementAdded · +797,369 sh+$29.6M
- BlackRockAdded · +701,040 sh+$26.0M
- AQR CAPITAL MANAGEMENTAdded · +647,930 sh+$24.0M
Biggest sellers
- T. Rowe Price Investment ManagementSold out · -1,488,740 sh-$55.2M
- MPM BioImpactSold out · -1,306,261 sh-$48.5M
- Frazier Life Sciences Management, L.P.Sold out · -1,256,080 sh-$46.6M
- WELLINGTON MANAGEMENT GROUP LLPTrimmed · -620,611 sh-$23.0M
- Erste Asset Management GmbHTrimmed · -550,000 sh-$20.4M
AGIO 13F holders ranked 1–100 of 239
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | BlackRock#1 · 6,455,997 sh | 6,455,997 | $239.6M | <0.01% | +12.2% |
| 2 | FARALLON CAPITAL MANAGEMENT#2 · 5,917,400 sh | 5,917,400 | $219.6M | 1.01% | +4.1% |
| 3 | STATE STREET#3 · 3,533,633 sh | 3,533,633 | $131.1M | <0.01% | +5.0% |
| 4 | Lynx1 Capital Management#4 · 3,408,937 sh | 3,408,937 | $126.5M | 24.92% | +30.5% |
| 5 | D. E. Shaw#5 · 3,107,005 sh | 3,107,005 | $115.3M | 0.05% | +15.9% |
| 6 | VANGUARD PORTFOLIO MANAGEMENT#6 · 2,898,197 sh | 2,898,197 | $107.6M | <0.01% | +11.0% |
| 7 | VANGUARD CAPITAL MANAGEMENT#7 · 2,681,845 sh | 2,681,845 | $99.5M | <0.01% | +1.9% |
| 8 | ARMISTICE CAPITAL#8 · 2,400,000 sh | 2,400,000 | $89.1M | 1.09% | -11.6% |
| 9 | Erste Asset Management GmbH#9 · 2,154,900 sh | 2,154,900 | $82.0M | 0.64% | -20.3% |
| 10 | NOMURA ASSET MANAGEMENT INTERNATIONAL#10 · 2,110,809 sh | 2,110,809 | $78.3M | 0.12% | +41.2% |
| 11 | GEODE CAPITAL MANAGEMENT#11 · 1,574,268 sh | 1,574,268 | $58.4M | <0.01% | +7.2% |
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP#12 · 1,375,558 sh | 1,375,558 | $51.0M | <0.01% | +2.3% |
| 13 | ADAR1 Capital Management#13 · 1,288,053 sh | 1,288,053 | $47.8M | 2.19% | +815.6% |
| 14 | BNP Paribas Asset Management Holding S.A.#14 · 1,280,044 sh | 1,280,044 | $47.5M | 0.05% | -19.0% |
| 15 | DIMENSIONAL FUND ADVISORS#15 · 1,248,738 sh | 1,248,738 | $46.3M | <0.01% | +8.4% |
| 16 | GW&K Investment Management#16 · 1,206,615 sh | 1,206,615 | $44.8M | 0.35% | -0.7% |
| 17 | GOLDMAN SACHS GROUP#17 · 1,150,932 sh | 1,150,932 | $42.7M | <0.01% | +42.8% |
| 18 | UBS Group AG#18 · 985,831 sh | 985,831 | $36.6M | <0.01% | +643.8% |
| 19 | MORGAN STANLEY#19 · 963,256 sh | 963,256 | $35.7M | <0.01% | -0.4% |
| 20 | Nuveen#20 · 873,560 sh | 873,560 | $32.4M | <0.01% | +20.9% |
| 21 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP#21 · 810,530 sh | 810,530 | $30.1M | 0.01% | +223.6% |
| 22 | Foresite Capital Management VI#22 · 785,000 sh | 785,000 | $29.1M | 4.53% | +49.5% |
| 23 | CITADEL ADVISORS#23 · 732,687 sh | 732,687 | $27.2M | <0.01% | +18.2% |
| 24 | AQR CAPITAL MANAGEMENT#24 · 684,340 sh | 684,340 | $25.4M | <0.01% | +1779.5% |
| 25 | Parkman Healthcare Partners#25 · 669,046 sh | 669,046 | $24.8M | 2.54% | +65.8% |
| 26 | SCS Capital Management#26 · 612,850 sh | 612,850 | $22.7M | 0.21% | 0.0% |
| 27 | Qube Research & Technologies Ltd#27 · 597,638 sh | 597,638 | $22.2M | 0.02% | +218.5% |
| 28 | NORTHERN#28 · 554,709 sh | 554,709 | $20.6M | <0.01% | +8.9% |
| 29 | Defilade Capital Management, L.P.#29 · 546,848 sh | 546,848 | $20.3M | 2.72% | New |
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT#30 · 538,128 sh | 538,128 | $20.0M | <0.01% | +12.8% |
| 31 | TWO SIGMA INVESTMENTS#31 · 536,380 sh | 536,380 | $19.9M | 0.01% | +113.2% |
| 32 | Rock Springs Capital Management#32 · 532,563 sh | 532,563 | $19.8M | 0.96% | -33.4% |
| 33 | Schonfeld Strategic Advisors#33 · 520,083 sh | 520,083 | $19.3M | 0.07% | +160.0% |
| 34 | BANK OF AMERICA#34 · 507,869 sh | 507,869 | $18.8M | <0.01% | 0.0% |
| 35 | Point72 Asset Management, L.P.#35 · 506,344 sh | 506,344 | $18.8M | 0.02% | New |
| 36 | JANE STREET GROUP#36 · 492,598 sh | 492,598 | $18.3M | <0.01% | -28.1% |
| 37 | Legal & General Group Plc#37 · 434,719 sh | 434,719 | $16.1M | <0.01% | +2.5% |
| 38 | VANGUARD FIDUCIARY#38 · 395,868 sh | 395,868 | $14.7M | <0.01% | +3.6% |
| 39 | PANAGORA ASSET MANAGEMENT#39 · 373,931 sh | 373,931 | $13.9M | 0.04% | +56.8% |
| 40 | KENNEDY CAPITAL MANAGEMENT#40 · 373,230 sh | 373,230 | $13.9M | 0.25% | +35.5% |
| 41 | JPMORGAN CHASE#41 · 359,756 sh | 359,756 | $13.8M | <0.01% | +137.4% |
| 42 | Connor, Clark & Lunn Investment Management Ltd.#42 · 359,550 sh | 359,550 | $13.3M | 0.03% | -20.1% |
| 43 | Squarepoint Ops#43 · 321,138 sh | 321,138 | $11.9M | 0.01% | +53.7% |
| 44 | Ensign Peak Advisors#44 · 297,630 sh | 297,630 | $11.0M | 0.02% | +4430.1% |
| 45 | BNP PARIBAS FINANCIAL MARKETS#45 · 269,383 sh | 269,383 | $10.0M | <0.01% | -17.7% |
| 46 | ALGERT GLOBAL#46 · 248,007 sh | 248,007 | $9.2M | 0.11% | -7.6% |
| 47 | PRICE T ROWE ASSOCIATES#47 · 218,966 sh | 218,966 | $8.1M | <0.01% | -26.7% |
| 48 | Palo Alto Investors#48 · 213,601 sh | 213,601 | $7.9M | 1.10% | 0.0% |
| 49 | TFG Asset Management GP Ltd#49 · 205,579 sh | 205,579 | $7.6M | 1.20% | +24.7% |
| 50 | Bank of New York Mellon#50 · 198,685 sh | 198,685 | $7.4M | <0.01% | +6.4% |
| 51 | Jump Financial#51 · 182,773 sh | 182,773 | $6.8M | 0.05% | New |
| 52 | Invesco Ltd.#52 · 168,153 sh | 168,153 | $6.2M | <0.01% | +11.0% |
| 53 | FIRST ADVISORS#53 · 165,587 sh | 165,587 | $6.1M | <0.01% | New |
| 54 | Ishara Investments#54 · 164,000 sh | 164,000 | $6.1M | 4.47% | New |
| 55 | HRT FINANCIAL#55 · 160,759 sh | 160,759 | $6.0M | 0.01% | -17.7% |
| 56 | GROUP ONE TRADING, L.P.#56 · 151,994 sh | 151,994 | $5.6M | <0.01% | -12.3% |
| 57 | BOOTHBAY FUND MANAGEMENT#57 · 149,886 sh | 149,886 | $5.6M | 0.07% | New |
| 58 | MARSHALL WACE, LLP#58 · 138,800 sh | 138,800 | $5.2M | <0.01% | -69.0% |
| 59 | AMERICAN CENTURY COMPANIES#59 · 134,512 sh | 134,512 | $5.0M | <0.01% | +11.9% |
| 60 | Man Group plc#60 · 124,466 sh | 124,466 | $4.6M | <0.01% | -13.7% |
| 61 | ArrowMark Colorado#61 · 117,714 sh | 117,714 | $4.4M | 0.18% | -70.8% |
| 62 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#62 · 116,909 sh | 116,909 | $4.3M | <0.01% | +5.6% |
| 63 | Pictet Asset Management Holding SA#63 · 111,861 sh | 111,861 | $4.2M | <0.01% | -13.2% |
| 64 | Swiss National Bank#64 · 111,660 sh | 111,660 | $4.1M | <0.01% | +2.6% |
| 65 | CAPITAL FUND MANAGEMENT S.A.#65 · 104,080 sh | 104,080 | $3.9M | 0.02% | -19.6% |
| 66 | Assenagon Asset Management S.A.#66 · 103,955 sh | 103,955 | $3.9M | — | +54.8% |
| 67 | Universal- Beteiligungs- und Servicegesellschaft mbH#67 · 99,726 sh | 99,726 | $3.7M | <0.01% | +64.4% |
| 68 | Knott David M Jr#68 · 95,058 sh | 95,058 | $3.5M | 1.86% | +2.1% |
| 69 | Trexquant Investment#69 · 93,539 sh | 93,539 | $3.5M | 0.02% | +24.2% |
| 70 | Jain Global#70 · 91,647 sh | 91,647 | $3.4M | 0.01% | New |
| 71 | CITIGROUP#71 · 89,167 sh | 89,167 | $3.3M | <0.01% | +421.6% |
| 72 | RHUMBLINE ADVISERS#72 · 79,441 sh | 79,441 | $2.9M | <0.01% | +8.3% |
| 73 | Campbell & Investment Adviser#73 · 73,095 sh | 73,095 | $2.7M | 0.14% | New |
| 74 | Exome Asset Management#74 · 70,500 sh | 70,500 | $2.6M | 1.61% | -43.6% |
| 75 | Edgestream Partners, L.P.#75 · 70,195 sh | 70,195 | $2.6M | 0.08% | -51.2% |
| 76 | Russell Investments Group, Ltd.#76 · 66,856 sh | 66,856 | $2.5M | <0.01% | +68.4% |
| 77 | TUDOR INVESTMENT ET AL#77 · 65,779 sh | 65,779 | $2.4M | <0.01% | +13.1% |
| 78 | DEUTSCHE BANK AG\#78 · 62,228 sh | 62,228 | $2.3M | <0.01% | +23.5% |
| 79 | ALPS ADVISORS#79 · 60,059 sh | 60,059 | $2.2M | 0.01% | +25.9% |
| 80 | Seven Fleet Capital Management#80 · 56,900 sh | 56,900 | $2.1M | 0.35% | -72.8% |
| 81 | ALLIANCEBERNSTEIN L.P.#81 · 61,864 sh | 61,864 | $2.1M | <0.01% | +0.6% |
| 82 | Rafferty Asset Management#82 · 55,580 sh | 55,580 | $2.1M | <0.01% | -45.9% |
| 83 | VIRGINIA RETIREMENT SYSTEMS ET Al#83 · 55,522 sh | 55,522 | $2.1M | <0.01% | +42.1% |
| 84 | Engineers Gate Manager#84 · 53,912 sh | 53,912 | $2.0M | 0.03% | +86.4% |
| 85 | WELLS FARGO & COMPANY#85 · 53,240 sh | 53,240 | $2.0M | <0.01% | +133.9% |
| 86 | VANGUARD ASSET MANAGEMENT, Ltd#86 · 52,050 sh | 52,050 | $1.9M | <0.01% | -11.3% |
| 87 | XTX Topco Ltd#87 · 50,366 sh | 50,366 | $1.9M | 0.02% | -68.7% |
| 88 | DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt#88 · 49,764 sh | 49,764 | $1.8M | <0.01% | New |
| 89 | BARCLAYS PLC#89 · 48,300 sh | 48,300 | $1.8M | <0.01% | -7.9% |
| 90 | HARBOR CAPITAL ADVISORS#90 · 46,550 sh | 46,550 | $1.7M | — | +8.2% |
| 91 | Quantinno Capital Management#91 · 43,514 sh | 43,514 | $1.6M | <0.01% | +57.7% |
| 92 | MARTINGALE ASSET MANAGEMENT L P#92 · 43,009 sh | 43,009 | $1.6M | 0.04% | +20.1% |
| 93 | MIRAE ASSET GLOBAL ETFS Ltd.#93 · 41,455 sh | 41,455 | $1.5M | <0.01% | -1.5% |
| 94 | IEQ CAPITAL#94 · 40,404 sh | 40,404 | $1.5M | <0.01% | New |
| 95 | Virtus Investment Advisers#95 · 39,473 sh | 39,473 | $1.5M | 0.34% | +27.5% |
| 96 | Caption Management#96 · 39,249 sh | 39,249 | $1.5M | <0.01% | +217.8% |
| 97 | FMR#97 · 39,072 sh | 39,072 | $1.4M | <0.01% | +328.4% |
| 98 | Aquatic Capital Management#98 · 38,627 sh | 38,627 | $1.4M | 0.05% | +241.2% |
| 99 | MANUFACTURERS LIFE INSURANCE COMPANY, THE#99 · 37,727 sh | 37,727 | $1.4M | <0.01% | -24.6% |
| 100 | SEI INVESTMENTS#100 · 35,089 sh | 35,089 | $1.3M | <0.01% | -44.8% |
Funds that sold out of AGIO in Q2 2026 (32)
Held AGIO at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| T. Rowe Price Investment Management1,488,740 sh | 1,488,740 | $50.4M |
| MPM BioImpact1,306,261 sh | 1,306,261 | $44.2M |
| Frazier Life Sciences Management, L.P.1,256,080 sh | 1,256,080 | $42.5M |
| Artisan Partners Limited Partnership481,516 sh | 481,516 | $16.3M |
| Vestal Point Capital450,000 sh | 450,000 | $15.2M |
| Eversept Partners200,000 sh | 200,000 | $6.8M |
| ESSEX INVESTMENT MANAGEMENT103,177 sh | 103,177 | $3.5M |
| TANG CAPITAL MANAGEMENT100,000 sh | 100,000 | $3.4M |
| Woodline Partners74,423 sh | 74,423 | $2.5M |
| Capital International Investors48,616 sh | 48,616 | $1.6M |
| SIMPLEX TRADING37,462 sh | 37,462 | $1.3M |
| Legato Capital Management32,373 sh | 32,373 | $1.1M |
| MILLENNIUM MANAGEMENT32,144 sh | 32,144 | $1.1M |
| PRELUDE CAPITAL MANAGEMENT29,085 sh | 29,085 | $983.9K |
| Virtu Financial21,392 sh | 21,392 | $724.0K |
| BALYASNY ASSET MANAGEMENT L.P.18,009 sh | 18,009 | $609.2K |
| Caitong International Asset Management , Ltd16,222 sh | 16,222 | $548.8K |
| PSP Research15,000 sh | 15,000 | $507.4K |
| Y-Intercept (Hong Kong) Ltd13,866 sh | 13,866 | $469.1K |
| Pale Fire Capital SE13,650 sh | 13,650 | $461.8K |
| Voleon Capital Management9,679 sh | 9,679 | $327.4K |
| NOMURA9,176 sh | 9,176 | $310.4K |
| Ground Swell Capital8,347 sh | 8,347 | $282.4K |
| FRANKLIN RESOURCES8,287 sh | 8,287 | $280.3K |
| Magnetar Financial5,936 sh | 5,936 | $200.8K |
| QUADRANT CAPITAL GROUP32 sh | 32 | $49.5K |
| SUMMIT SECURITIES GROUP408 sh | 408 | $13.8K |
| Advisory Services Network350 sh | 350 | $11.8K |
| Optiver Holding B.V.108 sh | 108 | $3.7K |
| Root Financial Partners44 sh | 44 | $1.5K |
| MAI Capital Management37 sh | 37 | $1.3K |
| RAFFA WEALTH MANAGEMENT32 sh | 32 | $1.1K |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.